Molecular cloning and characterization of a cDNA clone for a protein specifically expressed in embryo as well as in a chemically induced pancreatic B cell tumor of rat.

abstract：:Tankyrases (TNKS and TNKS2) are members of poly(ADP-ribose) polymerase (PARP) family proteins. Tankyrase has multiple ankyrin repeat cluster (ARC) domains, which recognize the tankyrase-binding motifs in proteins including the telomeric protein, TRF1 and Wnt signal regulators, AXINs. However, the functional significan...

journal_title：Biochemical and biophysical research communications

authors： Mizutani A,Seimiya H

更新日期：2020-02-19 00:00:00

abstract：:We have cloned the cDNA encoding human PICK1 (protein interacting with C kinase 1), a PDZ domain-containing protein of 415 amino acids, and also identified the Drosophila homologue by search of the databank. Northern blot analysis shows a single mRNA of about 2.0 kb ubiquitously expressed in human tissues. Although PI...

journal_title：Biochemical and biophysical research communications

authors： Takeya R,Takeshige K,Sumimoto H

更新日期：2000-01-07 00:00:00

abstract：:The protease, cancer procoagulant, was isolated from three murine metastatic tumors and was purified to apparent homogeneity (SDS-PAGE) from Lewis lung cells by the sequence of (NH4)2SO4 precipitation, DE-53 anion-exchange chromatography, and Sephacryl 200 chromatography. The murine tumor enzyme has a molecular weight...

journal_title：Biochemical and biophysical research communications

authors： Moore WR

更新日期：1992-04-30 00:00:00

abstract：:The current studies were designed to explore the effects of C-receptor-binding atrial natriuretic peptide analogues on serum-induced mitogenesis in cultured rat aortic smooth muscle cells. To this end, rANF99-126 and a series of truncated (rANF103-126, rANF103-125), ring-deleted (des[Gln116, Ser117, Gly118, Leu119, Gl...

journal_title：Biochemical and biophysical research communications

authors： Cahill PA,Hassid A

更新日期：1991-09-30 00:00:00

abstract：:Methylene blue (MB) is a blue cationic thiazine dye and currently used in different medical settings. Notably, there have been several attempts to introduce MB for attenuating pain in the last decade. Some clinical studies reported remarkable results, which, however, have been much debated. In addition, accumulating e...

journal_title：Biochemical and biophysical research communications

authors： Lee SW,Moon SW,Park JS,Suh HR,Han HC

更新日期：2021-01-16 00:00:00

abstract：:Gastric cancer (GC) remains a serious threat to human health with a high cancer-related death rate and unsatisfactory treatment effects after curative resection, especially with advanced GC. Thus, exploration of the molecular mechanism of cisplatin (CDDP) resistance in GC is crucial. circCCDC66 (hsa_circ_0001313) expr...

journal_title：Biochemical and biophysical research communications

authors： Zhang Q,Miao Y,Fu Q,Hu H,Chen H,Zeng A,Jin Y,Jiang Y,Qian L,Wu L,Xu L,Wang G,Qiu L,Huang X,Xia Y

更新日期：2020-06-04 00:00:00

abstract：:Clinicians successfully utilize high uptake of radiolabeled glucose via PET scanning to localize metastases in melanoma patients. To take advantage of this altered metabolome, 3-bromopyruvate (BrPA) was used to overcome the notorious resistance of melanoma to cell death. Using four melanoma cell lines, BrPA triggered ...

journal_title：Biochemical and biophysical research communications

authors： Qin JZ,Xin H,Nickoloff BJ

更新日期：2010-05-28 00:00:00

abstract：:A high yielding fusion protein system based on the protein cytochrome b(5) has been used for the production of novel 13-residue acyclic conopeptide. This peptide, Mo1659, can be liberated from the carrier protein using CNBr cleavage and subsequent purification using RP-HPLC methods. The yield of isotopically enriched ...

journal_title：Biochemical and biophysical research communications

authors： Kumar GS,Ramasamy P,Sikdar SK,Sarma SP

更新日期：2005-09-30 00:00:00

abstract：:Glycoprotein130 (gp130) is an important signal transducer in the interleukin-6 (IL-6) trans-signaling pathway, which plays a crucial role in chronic inflammation in atherosclerosis. Studies suggest that estrogen can inhibit IL-6/gp130 signaling and reduce the risk of coronary artery disease, but the precise mechanism ...

journal_title：Biochemical and biophysical research communications

authors： Zhou M,Dai W,Cui Y,Li Y

更新日期：2020-03-12 00:00:00

abstract：:The signal transduction of human 12(S)-lipoxygenase and the regulation of gene activation, induced by epidermal growth factor (EGF), are discussed in this review article. Treatment of human epidermoid carcinoma A431 cells with EGF induces the gene expression of human 12(S)-lipoxygenase, and two Sp1 binding sites resid...

journal_title：Biochemical and biophysical research communications

authors： Chang WC,Chen BK

更新日期：2005-12-09 00:00:00

abstract：:Recent environmental sampling around a landfill site in the UK demonstrated that unidentified xenoestrogens were present at higher levels than control sites; that these xenoestrogens were capable of super-activating (resisting ligand-dependent antagonism) the murine variant 2 ERβ and that the ionic liquid 1-octyl-3-me...

journal_title：Biochemical and biophysical research communications

authors： Leitch AC,Lakey AF,Hotham WE,Agius L,Kass GEN,Blain PG,Wright MC

更新日期：2018-09-10 00:00:00

abstract：:The hepatocyte growth factor is closely related to liver regeneration. And the c-met protooncogene is reported to encode a hepatocyte growth factor receptor. Little is known, however, about how the c-met gene is activated during liver regeneration. In this study, we demonstrated that expression of the c-met gene/hepat...

journal_title：Biochemical and biophysical research communications

authors： Ito T,Hayashi N,Horimoto M,Sasaki Y,Tanaka Y,Kaneko A,Fusamoto H,Kamada T

更新日期：1993-02-15 00:00:00

abstract：:The isolation of the genes located in chromosome 21 and the characterisation of their function are essential steps towards the understanding of the physiopathological mechanisms involved in Down syndrome. We have used two complementary approaches to characterise the function of the novel gene DSCR2 (Down Syndrome Crit...

journal_title：Biochemical and biophysical research communications

authors： Vidal-Taboada JM,Lu A,Pique M,Pons G,Gil J,Oliva R

更新日期：2000-05-27 00:00:00

abstract：:p8 is an 80 amino-acid polypeptide identified because of its remarkable over-expression in the stressed pancreas. This protein, apparently devoid of enzymatic activity, is a powerful regulator of several intracellular pathways, suggesting that it has to interact with several molecular partners to modulate their activi...

journal_title：Biochemical and biophysical research communications

authors： Malicet C,Hoffmeister A,Moreno S,Closa D,Dagorn JC,Vasseur S,Iovanna JL

更新日期：2006-01-06 00:00:00

abstract：:Two blind source separation methods (Independent Component Analysis and Non-negative Matrix Factorization), developed initially for signal processing in engineering, found recently a number of applications in analysis of large-scale data in molecular biology. In this short review, we present the common idea behind the...

journal_title：Biochemical and biophysical research communications

authors： Zinovyev A,Kairov U,Karpenyuk T,Ramanculov E

更新日期：2013-01-18 00:00:00

abstract：:GOTO cells, a neuroblastoma cell line retaining the ability to differentiate into neuronal or Schwann cells, were found to be rich in membrane rafts containing ganglioside GM2 and hypersensitive to lipid raft-disrupting methyl-beta-cyclodextrin (MbetaCD); the GM2-rich rafts and sensitivity to MbetaCD were markedly dim...

journal_title：Biochemical and biophysical research communications

authors： Tomioka R,Minami N,Kushida A,Horibe S,Izumi I,Kato A,Fukushima K,Ideo H,Yamashita K,Hirose S,Saito Y

更新日期：2009-11-06 00:00:00

abstract：:Alpha-L-fucosidase was purified from the bull seminal plasma by chromatography on DEAE-disk, octyl sepharose hydrophobic column and HPLC. The enzyme appeared to be pure as judged by the polyacrylamide gel electrophoresis both under the nondenaturing and denaturing conditions. The pure enzyme promoted the acrosome reac...

journal_title：Biochemical and biophysical research communications

authors： Srivastava PN,Arbtan K,Takei GH,Huang TT,Yanagimachi R

更新日期：1986-06-30 00:00:00

abstract：:Chronic myeloid leukemia (CML) responds well to BCR-ABL tyrosine kinase inhibitors (TKI), but becomes resistant to TKIs after it progresses to blast phase (BP). Here we show that niclosamide, a FDA-approved anthelmintic drug, enhances the sensitivity of BP-CML cells to dasatinib (2nd generation of BCR-ABL TKI) through...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Li Y,Lv C,Wang L,Song H

更新日期：2016-09-16 00:00:00

abstract：:Blebbistatin is a novel 1-phenyl-2-pyrrolidinone derivative capable of inhibiting non-muscle myosin II activity with a high degree of specificity. We examined the effects of blebbistatin on pancreatic adenocarcinoma cellular migration, invasion, adhesion, and spreading. Blebbistatin dose-dependently inhibited cellular...

journal_title：Biochemical and biophysical research communications

authors： Duxbury MS,Ashley SW,Whang EE

更新日期：2004-01-23 00:00:00

abstract：:This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Rai V,Datta K

更新日期：2010-04-10 00:00:00

abstract：:Tyrosine kinase inhibitors targeting the BCR-ABL oncoprotein in chronic myeloid leukemia (CML) are remarkably effective inducing deep molecular remission in most patients. However, they are less effective to eradicate the leukemic stem cells (LSC), resulting in disease persistence. Therefore, there is great need to de...

journal_title：Biochemical and biophysical research communications

authors： Dolinska M,Piccini A,Wong WM,Gelali E,Johansson AS,Klang J,Xiao P,Yektaei-Karin E,Strömberg UO,Mustjoki S,Stenke L,Ekblom M,Qian H

更新日期：2017-08-19 00:00:00

abstract：:Protein phosphorylation plays critical roles in the regulation of protein activity and cell signaling. The level of protein phosphorylation is controlled by protein kinases and protein tyrosine phosphatases (PTPs). Disturbance of the equilibrium between protein kinase and PTP activities results in abnormal protein pho...

journal_title：Biochemical and biophysical research communications

authors： Park JE,Park BC,Song M,Park SG,Lee DH,Park SY,Kim JH,Cho S

更新日期：2009-10-02 00:00:00

abstract：:The conformations of the neuropeptide galanin in water and trifluoroethanol solutions have been examined by 1H NMR spectroscopy. Analysis of two-dimensional NMR experiments enabled the assignment of virtually all the 1H resonances of galanin in trifluoroethanol solution and many of the 1H resonances in aqueous solutio...

journal_title：Biochemical and biophysical research communications

authors： Wennerberg AB,Cooke RM,Carlquist M,Rigler R,Campbell ID

更新日期：1990-02-14 00:00:00

abstract：:Autoimmune sera showing prominent immunofluorescence in nucleolus were selected and analysed by immunoblotting techniques. Immunoblots using a nucleolar extract as antigen source revealed sera recognizing a 38 kDa nucleolar protein. Low concentration of Actinomycin D, which inhibits the ribosomal RNA synthesis, caused...

journal_title：Biochemical and biophysical research communications

authors： Kindås-Mügge I

更新日期：1989-09-15 00:00:00

abstract：:We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP(-/-) mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholest...

journal_title：Biochemical and biophysical research communications

authors： Wu W,Tsuchida H,Kato T,Niwa H,Horikawa Y,Takeda J,Iizuka K

更新日期：2015-06-12 00:00:00

abstract：:The addition of low concentrations of the chemotactic factor fMet-Leu-Phe to rabbit neutrophils in the absence of cytochalasin B produces very little superoxide. This level of superoxide can be greatly increased in neutrophils pretreated for 30 min with 10 microM of the diacyl-glycerol kinase inhibitor R59022. This po...

journal_title：Biochemical and biophysical research communications

authors： Gomez-Cambronero J,Molski TF,Becker EL,Sha'afi RI

更新日期：1987-10-14 00:00:00

abstract：:Cytochrome P450 enzymes (CYP enzymes) catalyse the initial step in biotransformation of xenobiotics like polycyclic aromatic hydrocarbons (PAHs). The marine polychaete Nereis virens has a high capacity for biotransformation of PAHs. In the present study, the complete cDNA sequences of two novel CYP genes isolated from...

journal_title：Biochemical and biophysical research communications

authors： Jørgensen A,Rasmussen LJ,Andersen O

更新日期：2005-10-28 00:00:00

abstract：:The addition of the tumor-promoting phorbol 12-myristate, 13-acetate to rabbit neutrophils greatly potentiates the effect of the calcium ionophore A23187 on [3H]-arachidonic acid release and [32P]-phosphatidic acid generation. At 5 X 10(-8) M A23187, the addition of 20 ng/ml PMA potentiates the action of the ionophore...

journal_title：Biochemical and biophysical research communications

authors： Volpi M,Molski TF,Naccache PH,Feinstein MB,Sha'afi RI

更新日期：1985-04-30 00:00:00

abstract：:Major histocompatibility complex class II (MHC II) molecules are mainly expressed on antigen presentation cells and play an important role in immune response. It has been reported that MHC II molecules are also detected in serum as a soluble form (sMHC II molecules), and they are considered to be involved in the maint...

journal_title：Biochemical and biophysical research communications

authors： Shishido T,Kohyama M,Nakai W,Matsumoto M,Miyata H,Suenaga T,Arase H

更新日期：2019-01-29 00:00:00

abstract：:We recently demonstrated that metallothionein (MT)-1 A is a direct target gene negatively regulated by PU.1. In this study, we revealed that the expression of PU.1 was increased and accompanied by downregulation of MT-1A expression during TPA-induced THP-1 monocyte differentiation. Chromatin immunoprecipitation (ChIP)...

journal_title：Biochemical and biophysical research communications

authors： Suzuki S,Nakano H,Takahashi S

更新日期：2013-04-12 00:00:00