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SAPAP4 Deletion Causes Synaptic Dysfunction in the nucleus accumbens.

Abstract：

:SAP90/PSD95-associated proteins (SAPAPs) are one type of scaffold protein in the postsynaptic density (PSD). Scaffold proteins play an important role in synaptic function. Recently, many studies have shown that mutations associated with scaffold proteins cause dysfunction in neuronal circuitry and in behavior. SAPAP4, as a protein in the SAPAP family, may have an impact on synaptic functions and on behaviors. To test this hypothesis, mice with a genetic deletion of SAPAP4 were used in our study. SAPAP4-/- mice displayed decreased cocaine sensitivity behavior after an acute injection of 20 mg/kg cocaine. We also found that the spine density of medium spiny neurons (MSNs) in the nucleus accumbens (NAc) shell was reduced in SAPAP4-/- mice. Furthermore, SAPAP4-/- mice displayed altered synaptic transmission and a decreased frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs) in the NAc. Our findings demonstrate that SAPAP4 plays a critical role in cocaine-related behavior and in the synaptic function of the NAc.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wu B,Li C,Lei H

doi

10.1016/j.bbrc.2018.10.016

subject

Has Abstract

pub_date

2018-11-10 00:00:00

pages

1223-1227

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)32158-2

journal_volume

505

pub_type

杂志文章

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