当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Spinal miR-34a regulates inflammatory pain by targeting SIRT1 in complete Freund's adjuvant mice.

Spinal miR-34a regulates inflammatory pain by targeting SIRT1 in complete Freund's adjuvant mice.

Abstract：

:Sirtuin1 (SIRT1), which is regulated by microRNA-34a (miR-34a), can modulate pathophysiology processes, including nonalcoholic fatty liver disease and intestinal ischemia/reperfusion injury. We previously reported that SIRT1, an NAD+-dependent deacetylase, plays a vital role in the development of neuropathic pain. However, the role of miR-34a/SIRT1 in complete Freund's adjuvant (CFA)-induced inflammatory pain remains unclear. In the present study, we examined miR-34a and SIRT1 in CFA mice. MiR-34a levels increased, while SIRT1 decreased in the spinal cord. Inhibiting miR-34a by intrathecal injection of miR-34a antagomir attenuated CFA-induced pain behavior. Moreover, miR-34a antagomir inhibited the CFA-induced SIRT1 decrease in the spinal cord. Furthermore, the analgesic effect of miR-34a antagomir was abrogated by the SIRT1 inhibitor EX-527. Our data provide support that the underlying mechanisms of miR-34a in promoting inflammatory pain may involve negative regulation of SIRT1.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chen S,Gu Y,Dai Q,He Y,Wang J

doi

10.1016/j.bbrc.2019.07.002

subject

Has Abstract

pub_date

2019-09-03 00:00:00

pages

1196-1203

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)31327-0

journal_volume

516

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • PPARγ alleviated hepatocyte steatosis through reducing SOCS3 by inhibiting JAK2/STAT3 pathway.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) participates in the process of insulin resistance (IR), a crucial pathophysiology in non-alcoholic fatty liver disease (NAFLD). Meanwhile, suppressor of cytokine signaling3 (SOCS3) also regulates IR in NAFLD. Both PPARγ and SOCS3 play a role in NAFLD through reg...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.03.110

    authors： Bi J,Sun K,Wu H,Chen X,Tang H,Mao J

    更新日期：2018-04-15 00:00:00

  • The expression of inhibin beta B is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease.

    abstract：:Adipose tissue is an endocrine organ that produces and secretes adipokines. The aim of this study was to identify genes predominantly expressed in human subcutaneous adipocytes. For this purpose, an algorithm was developed and DNA microarray expression profiles from 33 human tissues and cell types were used to select ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.04.030

    authors： Sjöholm K,Palming J,Lystig TC,Jennische E,Woodruff TK,Carlsson B,Carlsson LM

    更新日期：2006-06-16 00:00:00

  • Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site.

    abstract：:Selective modification of one (of three) tyrosine residue per enzyme monomer leads to inactivation of dUTPase of the retrovirus equine infectious anemia virus (EIAV). The substrate dUMP and the cofactor Mg2+ protect against inactivation and modification, in agreement with the study on E. coli dUTPase (Vertessy et al. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0226

    authors： Vertessy BG,Persson R,Rosengren AM,Zeppezauer M,Nyman PO

    更新日期：1996-02-15 00:00:00

  • Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on glucose concentration and role of AMPK.

    abstract：:Metformin, a widely used anti-diabetic drug, is emerging as a potential anticancer agent but the mechanisms involved remain incompletely understood. Here, we demonstrate that the potency of metformin induced AMPK activation, as shown by the phosphorylation of its substrates acetyl-CoA carboxylase (ACC) at Ser(79) and ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.11.010

    authors： Sinnett-Smith J,Kisfalvi K,Kui R,Rozengurt E

    更新日期：2013-01-04 00:00:00

  • PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced apoptosis.

    abstract：:We have previously reported that the two components of R2TP complex, RNA polymerase II-associated protein 3 (RPAP3), and Reptin, regulate apoptosis. Here we characterize another component of the complex, PIH1 domain containing protein 1 (PIH1D1). PIH1D1 interacts with both RPAP3 and Monad in HEK293 or U2OS cells. PIH1...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.11.031

    authors： Inoue M,Saeki M,Egusa H,Niwa H,Kamisaki Y

    更新日期：2010-12-17 00:00:00

  • Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-κB activation.

    abstract：:Toll-like receptors (TLRs) are important initiators in innate immune responses against pathogenic microbes such as viruses, intracellular bacteria or parasites. Although the innate immune system is designed to fight infectious pathogens, excessive activation of TLR signaling may lead to unwarranted inflammation with h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.03.071

    authors： Liu J,Zhang Z,Chai L,Che Y,Min S,Yang R

    更新日期：2013-04-26 00:00:00

  • Degrading activity for human parathyroid hormone [PTH-(1-84)] in rat osteoblast-like osteosarcoma cell line UMR106.

    abstract：:The degrading activity for human parathyroid hormone [hPTH-(1-84)] was studied in a rat osteoblast-like osteosarcoma cell line UMR106. At 37 C,UMR106 cells degraded hPTH-(1-84) into fragments in a time-dependent manner, which was shown by a radioimmunoassay with the use of antibody recognizing the C-terminal and middl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80238-8

    authors： Yamaguchi T,Baba H,Fukase M,Kinoshita Y,Fujimi T,Fujita T

    更新日期：1986-12-15 00:00:00

  • Protein kinase activity of rat brain hexokinase.

    abstract：:Hexokinase 1 (HK1) purified from rat brain exhibits protein kinase activity, including autophosphorylation and phosphorylation of histone H2A. This protein kinase activity is observed only in the absence of the HK1 carbohydrate substrate, glucose. Analysis of the ATP-binding domains of the mammalian HK1 protein sequen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90652-n

    authors： Adams V,Griffin LD,Gelb BD,McCabe ER

    更新日期：1991-06-28 00:00:00

  • Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation.

    abstract：:Amyloid beta precursor protein (APP) is normally cleaved by α-secretase, but can also be cleaved by β-secretase (BACE1) to produce C99 fragments in the endoplasmic reticulum (ER) membrane. C99 is subsequently cleaved to amyloid β (Aβ), the aggregation of which is known to cause Alzheimer's disease. Therefore, C99 remo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.03.060

    authors： Jang JK,Park KJ,Lee JH,Ko KY,Kang S,Kim IY

    更新日期：2017-04-29 00:00:00

  • Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair.

    abstract：:Vascular remodeling characterized by hyperproliferative neointima formation is an unfavorable repair process that is triggered by vascular damage. This process is characterized by an increased local inflammatory and proliferative response that critically involves the pro-inflammatory cytokine interleukin-1β (IL-1β). I...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.07.006

    authors： Schlaweck S,Zimmer S,Struck R,Bartok E,Werner N,Bauernfeind F,Latz E,Nickenig G,Hornung V,Ghanem A

    更新日期：2011-08-05 00:00:00

  • The hemopexin-type repeats of human vitronectin are recognized by Streptococcus pyogenes.

    abstract：:The specific binding of vitronectin to Streptococcus pyogenes is believed to play an important role in the infection process by mediating adherence of the bacteria to host cells. The domain of vitronectin involved in the interaction with S. pyogenes is unknown. In the present study, we constructed a vitronectin random...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6663

    authors： Liang OD,Preissner KT,Chhatwal GS

    更新日期：1997-05-19 00:00:00

  • 2'-Amino-2'-deoxyguanosine is a cofactor for self-splicing in group I catalytic RNA.

    abstract：:In investigations on self-splicing in the group I intron of the pre-mRNA from the nrdB gene of bacteriophage T4 it was found that 2'-amino-2'-deoxyguanosine can replace guanosine as cofactor. This is the first guanosine-analogue with a modification in the 2'-position and substantial activity in a group I self-splicing...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90560-8

    authors： Strömberg R,Hahne S,Sjögren AS,Sjöberg BM

    更新日期：1992-03-16 00:00:00

  • Generation of ERα-floxed and knockout mice using the Cre/LoxP system.

    abstract：:Estrogen receptor alpha (ERα) is a nuclear receptor that regulates a range of physiological processes in response to estrogens. In order to study its biological role, we generated a floxed ERα mouse line that can be used to knock out ERα in selected tissues by using the Cre/LoxP system. In this study, we established a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.07.016

    authors： Antonson P,Omoto Y,Humire P,Gustafsson JÅ

    更新日期：2012-08-10 00:00:00

  • Identification and characterization of an endoplasmic reticulum localization motif.

    abstract：:Sorting motifs are involved in the transport of diverse proteins. In the present study, we identified a hydrophobic peptide (WRPWRNFWWSIRVPWRRN) that was able to target enhanced green fluorescent protein- or DsRed2-enriched vesicular-like sub-compartments of the endoplasmic reticulum (ER). Analysis of mutation constru...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.03.087

    authors： Nie YW,Wang M,Zhang P,Huan L,Liu DJ

    更新日期：2016-04-22 00:00:00

  • Increased antiviral and opsonic activity of a highly multimerized collectin chimera.

    abstract：:Altering the carbohydrate binding properties of surfactant protein D (SP-D) [e.g., by replacing its carbohydrate recognition domain (CRD) with that of either mannose binding lectin (MBL) or conglutinin] can increase its activity against influenza A virus (IAV). The current study demonstrates that the degree of multime...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5373

    authors： White MR,Crouch E,Chang D,Hartshorn KL

    更新日期：2001-08-10 00:00:00

  • Stimulation of Mn-superoxide dismutase expression by tumor necrosis factor-alpha: quantitative determination of Mn-SOD protein levels in TNF-resistant and sensitive cells by ELISA.

    abstract：:Marked increase in protein levels of Mn-superoxide dismutase (Mn-SOD) was found in TNF-resistant cell lines after treatment with Tumor Necrosis Factor (TNF). No such increase was observed in Cu,Zn-superoxide dismutase (Cu, Zn-SOD) protein in either TNF-resistant or sensitive cells. These results support the data that ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90838-e

    authors： Kawaguchi T,Takeyasu A,Matsunobu K,Uda T,Ishizawa M,Suzuki K,Nishiura T,Ishikawa M,Taniguchi N

    更新日期：1990-09-28 00:00:00

  • Tensile forces attenuate estrogen-stimulated collagen synthesis in the ACL.

    abstract：:The purpose of this study was to examine whether mechanical tensile forces affect estrogen regulation of collagen synthesis of anterior cruciate ligament fibroblasts at the mRNA level. Estrogen was studied at three physiologic levels, 10(-11), 10(-10), and 10(-9)M. The results revealed that estrogen alone stimulated T...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.174

    authors： Lee CY,Smith CL,Zhang X,Hsu HC,Wang DY,Luo ZP

    更新日期：2004-05-14 00:00:00

  • Structural analysis of invasion plasmid antigen D (IpaD) from Shigella flexneri.

    abstract：:Invaison plasmid antigen D (IpaD) and water-extracted outer-membrane proteins (OMPs) from Shigella flexneri were used to investigate some of the structural relationships of this pathogen's invasions. Extracellular presentation of the three invasion plasmid antigens (Ipa) B, C, and D is required for the S. flexneri inv...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2380

    authors： Marquart ME,Picking WL,Picking WD

    更新日期：1995-09-25 00:00:00

  • Characterization of a novel arachidonic acid-derived neutrophil chemoattractant.

    abstract：:The oxidation of arachidonic acid in a superoxide-generating environment results in the formation of a potent chemoattractant that appears to be identical to a chemotactic material generated by hepatocytes when they metabolize alcohol. The product was extracted, chromatographed and characterized by physical methods in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80803-4

    authors： Roll FJ,Perez HD,Serhan CN

    更新日期：1992-07-15 00:00:00

  • Four unreported types of glycans containing mannose-6-phosphate are heterogeneously attached at three sites (including newly found Asn 233) to recombinant human acid alpha-glucosidase that is the only approved treatment for Pompe disease.

    abstract：:Myozyme is a recombinant human acid alpha-glucosidase (rhGAA) that is currently the only drug approved for treating Pompe disease, and its low efficacy means that a high dose is required. Mannose-6-phosphate (M6P) glycosylation on rhGAA is a key factor influencing lysosomal enzyme targeting and the efficacy of enzyme ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.12.101

    authors： Park H,Kim J,Lee YK,Kim W,You SK,Do J,Jang Y,Oh DB,Il Kim J,Kim HH

    更新日期：2018-01-22 00:00:00

  • Insulin-like growth factor binding protein 3 (IGF-BP3) inhibits estrogen-stimulated breast cancer cell proliferation.

    abstract：:We have recently demonstrated that exposure of MCF7 cells to antiestrogens in vitro results in both accumulation of IGF-BP3 in media and reduced mitogenic responsivity to IGFs (Cancer Res. 53:5193-5198). We show here that MCF7 cell proliferation in steroid-stripped, serum containing media is significantly attenuated b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1041

    authors： Pratt SE,Pollak MN

    更新日期：1994-01-14 00:00:00

  • Molecular cloning and nucleotide sequence of complementary DNA encoding rabbit alpha 1-acid glycoprotein.

    abstract：:Alpha 1-acid glycoprotein (AGP) complementary DNA clone has been isolated from an acute phase rabbit liver library. Complete and full-length nucleotide sequence of this cDNA has been determined. The cDNA contains 35 nucleotides 5' untranslated region followed by 606 nucleotides of coding region and a 112 nucleotides 3...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90136-u

    authors： Ray BK,Ray A

    更新日期：1991-07-31 00:00:00

  • The cbbQ genes, located downstream of the form I and form II RubisCO genes, affect the activity of both RubisCOs.

    abstract：:Hydrogenovibrio marinus strain MH-110, an obligately lithoautotrophic hydrogen-oxidizing bacterium, possesses three sets of the genes for ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO): namely, two form I type (cbbLS-1 and cbbLS-2) and one form II type (cbbM) enzymes. The cbbQ-m gene was located downstream ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1103

    authors： Hayashi NR,Arai H,Kodama T,Igarashi Y

    更新日期：1999-11-01 00:00:00

  • Proteolipid protein from the peripheral nervous system also contains covalently bound fatty acids.

    abstract：:Proteolipid protein, the major protein component of central nervous system (CNS) myelin, is known to contain approximately 2% by weight of covalently bound fatty acids. Recently, this protein was also found, though at a lower concentration, in the peripheral nervous system (PNS). The present study was undertaken to de...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1767

    authors： Tetzloff SU,Bizzozero OA

    更新日期：1993-06-30 00:00:00

  • Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells.

    abstract：:Human embryonic stem cells (hESCs) are thought to be a promising cell source for cell transplantation therapy. For such a clinical application, the hESCs should be manipulated using appropriate and qualified materials. In this study, we examined the efficacy of recombinant human laminin (rhLM) isoforms on the undiffer...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.07.111

    authors： Miyazaki T,Futaki S,Hasegawa K,Kawasaki M,Sanzen N,Hayashi M,Kawase E,Sekiguchi K,Nakatsuji N,Suemori H

    更新日期：2008-10-10 00:00:00

  • Identification of an arginine vasopressin-like diuretic hormone from Locusta migratoria.

    abstract：:We have identified two neuropeptides (F1 and F2) from suboesophageal and thoracic ganglia of Locusta migratoria, which we isolated earlier based on their immunological similarity to arginine vasopressin. The more abundant and hydrophilic factor, F1, has sequence Cys-Leu-Ile-Thr-Asn-Cys-Pro-Arg-Gly-NH2, but its biologi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91621-4

    authors： Proux JP,Miller CA,Li JP,Carney RL,Girardie A,Delaage M,Schooley DA

    更新日期：1987-11-30 00:00:00

  • Down-regulation of RalBP1 expression reduces seizure threshold and synaptic inhibition in mice.

    abstract：:Idiopathic epilepsy is characterized by seizures without a clear etiology and is believed to have a strong genetic component but exhibits a complex inheritance pattern. Genetic factors seem to confer a low seizure threshold to susceptible individuals and thereby enhance epileptogenesis. However, the identity of suscep...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.02.056

    authors： Bae YS,Chung W,Han K,Park KY,Kim H,Kim E,Kim MH

    更新日期：2013-04-05 00:00:00

  • Purification and characterization of human recombinant insulin-like growth factor binding protein 3 expressed in Chinese hamster ovary cells.

    abstract：:Recombinant human insulin-like growth factor binding protein 3 (hIGFBP-3) stably expressed in chinese hamster ovary cells (CHO cells) has been purified to homogeneity from serum-free culture media. The purified protein migrates as a doublet (45/43 kDa) upon SDS-PAGE. The purified recombinant hIGFBP-3 is fully active a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90154-y

    authors： Tressel TJ,Tatsuno GP,Spratt K,Sommer A

    更新日期：1991-07-31 00:00:00

  • Specific interaction of pRB with a rat genomic DNA fragment, REC11.

    abstract：:The retinoblastoma gene product (pRB) has been known to contain a sequence-nonspecific DNA binding activity. It is unknown whether pRB can recognize and bind to specific DNA sequences. We have recently identified a rat genomic DNA fragment, termed REC11, which can interact with rat Cdc37-related protein (RCdc37). In t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1339

    authors： Ozaki T,Sakiyama S

    更新日期：1996-09-04 00:00:00

  • Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy.

    abstract：:Mitochondria dysfunction plays a significant role in the apoptosis of retinal cells. Diabetes activates retinal matrix metalloproteinases (MMP-9 and MMP-2), damages retinal mitochondria and activates the apoptotic machinery. This study is to investigate the temporal relationship between the activation of retinal MMPs ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.07.066

    authors： Santos JM,Tewari S,Lin JY,Kowluru RA

    更新日期：2013-09-06 00:00:00