Structural analysis of invasion plasmid antigen D (IpaD) from Shigella flexneri.

Abstract:

:Invaison plasmid antigen D (IpaD) and water-extracted outer-membrane proteins (OMPs) from Shigella flexneri were used to investigate some of the structural relationships of this pathogen's invasions. Extracellular presentation of the three invasion plasmid antigens (Ipa) B, C, and D is required for the S. flexneri invasive phenotype; however, little is known of the structural properties of these essential virulence components. Biochemical data suggest IpaB, C, and D present in S. flexneri OMPs from soluble protein complexes and IpaD may be able to form large homopolymeric complexes.

authors

Marquart ME,Picking WL,Picking WD

doi

10.1006/bbrc.1995.2380

subject

Has Abstract

pub_date

1995-09-25 00:00:00

pages

963-70

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)72380-7

journal_volume

214

pub_type

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