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Inhibition of human brain dihydropteridine reductase [E.C.1.6.99.10] by the oxidation products of catecholamines, the aminochromes.

Abstract：

:Dihydropteridine reductase from human brain has been purified to homogeneity using a naphthaquinone affinity column followed by chromatography on a 5'-AMP-Sepharose column. Contrary to earlier findings, dopamine (I), noradrenaline (II), and adrenaline (III) do not inhibit this enzyme at concentrations below 200 microM, but their oxidation products, the respective aminochromes (IV, V and VI) are inhibitors. The Ki values for adrenochrome (VI) are reported.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Armarego WL,Waring P

doi

10.1016/0006-291x(83)91083-5

subject

Has Abstract

pub_date

1983-06-29 00:00:00

pages

895-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(83)91083-5

journal_volume

113

pub_type

杂志文章

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