Human trophoblast noncoding RNA suppresses CIITA promoter III activity in murine B-lymphocytes.

abstract：:Natural Killer (NK) cells are highly mobile, specialized sub-populations of lymphocytic cells that survey their host to identify and eliminate infected or tumor cells. They are one of the key players in innate immunity and do not need prior activation through antigen recognition to deliver cytotoxic packages and relea...

journal_title：Biochemical and biophysical research communications

authors： Tompkins N,MacKenzie B,Ward C,Salgado D,Leidal A,McCormick C,Pohajdak B

更新日期：2014-08-22 00:00:00

abstract：:Lung cancer accounts for the highest death rate among cancers worldwide, with most patients being diagnosed with non-small cell lung cancer (NSCLC), urging more effective therapies. We report that JK273, a pyrrolo[2,3-d]pyrimidine analog, which inhibits α4 integrin signaling, showed a selective cytotoxic effect agains...

journal_title：Biochemical and biophysical research communications

authors： Lu TN,Ganganna B,Pham TT,Vo AV,Lu TP,Nguyen HT,Nguyen MT,Huynh PN,Truong NT,Lee J

更新日期：2017-09-16 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells isolated from many adult tissues. Previous studies reported that MSCs can differentiate to both mesodermal and neural lineages by a phenomenon referred to as ''dedifferentiation'' or ''transdifferentiation''. However, since MSCs have only b...

journal_title：Biochemical and biophysical research communications

authors： Morikawa S,Mabuchi Y,Niibe K,Suzuki S,Nagoshi N,Sunabori T,Shimmura S,Nagai Y,Nakagawa T,Okano H,Matsuzaki Y

更新日期：2009-02-20 00:00:00

abstract：:We have identified a human pituitary protein as a novel glycosylated variant of hGH. Isolation of the denatured protein included separation of human pituitary extract by Sephadex G-100 chromatography in ammonium bicarbonate, followed by Sephadex G-100 chromatography in 10% acetic acid, with subsequent DEAE Sephacryl c...

journal_title：Biochemical and biophysical research communications

authors： Haro LS,Lewis UJ,Garcia M,Bustamante J,Martinez AO,Ling NC

更新日期：1996-11-12 00:00:00

abstract：:RNA-binding proteins are believed to play important roles in regulation of neural functions. Recently, a mouse cDNA encoding the cold-inducible RNA-binding protein, Cirp, has been isolated, the amino acid sequence of which showed similarity to plant circadian rhythm proteins. In the present study, diurnal expression o...

journal_title：Biochemical and biophysical research communications

authors： Nishiyama H,Xue JH,Sato T,Fukuyama H,Mizuno N,Houtani T,Sugimoto T,Fujita J

更新日期：1998-04-17 00:00:00

abstract：:Previous work had suggested the presence of significant levels of UDP-glucuronosyltransferase 1A1 (UGT1A1) catalytic activity in human small intestinal microsomes, with undetectable to low UGT1A6 and 2B7 activities. To confirm the presence of UGT1A1 isoform in human small bowel, to explore the possible absence of UGT1...

journal_title：Biochemical and biophysical research communications

authors： Paine MF,Fisher MB

更新日期：2000-07-14 00:00:00

abstract：:Quercetin, a polyphenol, belongs to a class of flavonoids that exerts anti-inflammatory effects. Interleukin (IL)-18 is a member of the IL-1 family cytokine that regulates immune responses and is implicated in various inflammatory skin diseases. Absent in melanoma 2 (AIM2) is a cytosolic double-stranded (ds) DNA senso...

journal_title：Biochemical and biophysical research communications

authors： Lee KM,Kang JH,Yun M,Lee SB

更新日期：2018-09-03 00:00:00

abstract：:We have investigated the angiogenic effects of basic fibroblast growth factor following its implantation in slow release beads under the kidney capsule. The presence of basic fibroblast growth factor in the subcapsular space induced a marked angiogenic response maximal at 1 microgram dose per kidney. Histological exam...

journal_title：Biochemical and biophysical research communications

authors： Hayek A,Culler FL,Beattie GM,Lopez AD,Cuevas P,Baird A

更新日期：1987-09-15 00:00:00

abstract：:The gene III protein (pIII) from phi Lf, a filamentous phage of Xanthomonas campestris pv.campestris, was purified by gel filtration with FPLC. The gIII coding region was amplified by PCR, which was then cloned into pUC18 and expressed in Escherichia coli. The size of both pIII, purified from phage particle and expres...

journal_title：Biochemical and biophysical research communications

authors： Liu TJ,You BY,Lin NT,Yang MT,Tseng YH

更新日期：1998-01-06 00:00:00

abstract：:The chloroethylnitrosoureas are useful antitumor agents which evidently exert a significant part of their cytotoxic action through the formation of a unique 1-(3-deoxycytidyl), 2-(1-deoxyguanosinyl)ethane cross-link in DNA. It has been suggested that this cross-link is formed from O6-(2-chloro-ethyl)guanine, an initia...

journal_title：Biochemical and biophysical research communications

authors： Parker S,Kirk MC,Ludlum DB

更新日期：1987-11-13 00:00:00

abstract：:Evidence exists that the adenosine receptor A(2A)R and the dopamine receptor D(2)R form constitutive heteromers in living cells. Mass spectrometry and pull-down data showed that an arginine-rich domain of the D(2)R third intracellular loop binds via electrostatic interactions to a specific motif of the A(2A)R C-termin...

journal_title：Biochemical and biophysical research communications

authors： Borroto-Escuela DO,Marcellino D,Narvaez M,Flajolet M,Heintz N,Agnati L,Ciruela F,Fuxe K

更新日期：2010-03-26 00:00:00

abstract：:Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP. We have found that elevations in cyclic AMP (cAMP) have long-term effects on both the beta-adrenergic receptor and adenylyl cyclase in cultured chick ventricular myocytes. Pretreatmen...

journal_title：Biochemical and biophysical research communications

authors： Cui H,Green RD

更新日期：2003-07-18 00:00:00

abstract：:We describe a novel technology for detecting nucleic acids: Probe Alteration Link Self-Assembly Reactions (PALSAR). PALSAR comprises DNA self-assembly of pairs of short DNA probes formed by alternate hybridization of three complementary regions in a pair of honeycomb probes (HCPs). Self-assembly occurs at designated s...

journal_title：Biochemical and biophysical research communications

authors： Usui M,Fujikawa T,Osawa M,Hakii C,Ikumi N,Nozaki T,Kitamura N,Hatta Y,Fujiwara S,Takei M

更新日期：2015-11-27 00:00:00

abstract：:The activation of c-jun N-terminal kinase (JNK) in pancreatic islets is associated with impaired function and viability, and JNK inhibitory peptides (JNKIs) are cytoprotective. In particular, l-isoforms of JNKIs were shown to improve islets viability, while the d-retroinverso isoform of JNKI (RI-JNKI), with a higher t...

journal_title：Biochemical and biophysical research communications

authors： Fornoni A,Cobianchi L,Sanabria NY,Pileggi A,Molano RD,Ichii H,Rosero S,Inverardi L,Ricordi C,Pastori RL

更新日期：2007-03-02 00:00:00

abstract：:The current state of the AD research field is highly dynamic is some respects, while seemingly stagnant in others. Regarding the former, our current lack of understanding of initiating disease mechanisms, the absence of effective treatment options, and the looming escalation of AD patients is energizing new research d...

journal_title：Biochemical and biophysical research communications

authors： Briggs CA,Chakroborty S,Stutzmann GE

更新日期：2017-02-19 00:00:00

abstract：:Placental choriocarcinoma, a reproductive system carcinoma in women, has about 0.81% occurrence frequency in China, which leads to over 90% lethality due to indistinct pathogenesis and the absence of efficient therapeutic treatment. In the present study, using immunostaining and reverse transcription PCR, we reported ...

journal_title：Biochemical and biophysical research communications

authors： Peng S,Miao C,Li J,Fan X,Cao Y,Duan E

更新日期：2006-11-24 00:00:00

abstract：:Human leukemic HL60 cells are known to express NAD glycohydrolase (NADase) activity following differentiation into macrophage-like cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) or granulocyte-like cells by retinoic acid (RA) treatment. Recently, it was reported that 46 kDa human leukocyte antigen, CD38, expresse...

journal_title：Biochemical and biophysical research communications

authors： Han MK,An NH,Kim UH

更新日期：1995-08-15 00:00:00

abstract：:Our prior studies showed that certain cobalamins inhibit productive HIV-1 infection of primary cultures of blood lymphocytes and monocytes. We demonstrate here that this antiviral activity may be mediated by an inhibition of HIV-1 integrase, an enzyme required for productive infection. Purified recombinant HIV-1 integ...

journal_title：Biochemical and biophysical research communications

authors： Weinberg JB,Shugars DC,Sherman PA,Sauls DL,Fyfe JA

更新日期：1998-05-19 00:00:00

abstract：:Several studies support a role for the multiple tumor suppressor gene (MTS1) in the malignant progression of different tumor types. In this study we have examined the status of the MTS1 gene in a variety of non-astrocytic tumors of the central nervous system. It was not possible, using multiplex PCR with primers for M...

journal_title：Biochemical and biophysical research communications

authors： Walker DG,Duan W,Kaye AH,Lavin MF

更新日期：1995-06-15 00:00:00

abstract：:We propose that one manifestation of altered sphingolipid metabolism within tumor cells may be a reduced sensitivity to anti-cancer therapies because of an inability to produce a sufficient apoptotic signal via sphingomyelin hydrolysis to ceramide. If so, then sphingomyelin administration could reverse this effect and...

journal_title：Biochemical and biophysical research communications

authors： Modrak DE,Lew W,Goldenberg DM,Blumenthal R

更新日期：2000-02-16 00:00:00

abstract：:Deficient apoptosis of activated T cells can result in immunological disorders. Molecules associated with energy and metabolisms are suggested to be involved in pathogenesis of immune diseases, but remain uninvestigated. In the present study we reported that glibenclamide exerted a new pharmacological effect on inflam...

journal_title：Biochemical and biophysical research communications

authors： Ouyang Z,Wang X,Meng Q,Feng L,Sun Y,Wu X,Xu Q

更新日期：2017-05-27 00:00:00

abstract：:In this study, we report the effect of endothelial progenitor cells (EPCs) on the biological behavior of osteoclast precursors in vitro by establishing an indirect co-culture system of mice EPCs and RAW 264.7 monocyte cells. Results show that the survival, migration, and differentiation of osteoclast precursors were g...

journal_title：Biochemical and biophysical research communications

authors： Pang H,Wu XH,Fu SL,Luo F,Zhang ZH,Hou TY,Li ZQ,Chang ZQ,Yu B,Xu JZ

更新日期：2013-01-11 00:00:00

abstract：:By DNA sequence analysis, we have determined a spectrum of 61 spontaneous mutations occurring in the endogenous tonB gene in the polA1 strain of Escherichia coli. The overall mutation frequency was approximately 2.4-fold higher in the polA1 strain and this was attributable to enhanced rates of deletion and frameshift ...

journal_title：Biochemical and biophysical research communications

authors： Agemizu Y,Uematsu N,Yamamoto K

更新日期：1999-08-11 00:00:00

abstract：:Human bone marrow cells express both a truncated and full-length form of the erythropoietin receptor (EpoR-T and EpoR-F, respectively). Transfection experiments using the murine interleukin (IL)-3-dependent cell line, Ba/F3, revealed that the cells coexpressing EpoR-F and EpoR-T (Ba/F3-FT) were more likely to undergo ...

journal_title：Biochemical and biophysical research communications

authors： Shimizu R,Komatsu N,Nakamura Y,Nakauchi H,Nakabeppu Y,Miura Y

更新日期：1996-05-06 00:00:00

abstract：:Binding of cytochrome b5 to rat cytochrome P450 2B1 was inhibited (by 75%) by a synthetic peptide corresponding to P450 residues 116-134. The role of Lys-122 and Arg-125 were evaluated using peptides in which one or both of these basic residues were replaced with Glu. The Lys-122 substitution nearly abolished while th...

journal_title：Biochemical and biophysical research communications

authors： Omata Y,Sakamoto H,Robinson RC,Pincus MR,Friedman FK

更新日期：1994-06-30 00:00:00

abstract：:Green tea catechins have been shown to attenuate obesity in animals and humans. The catechins activate adenosine monophosphate-activated protein kinase (AMPK), and thereby increase fatty acid oxidation in liver and skeletal muscles. Green tea catechins have also been shown to reduce body fat in humans. However, the ef...

journal_title：Biochemical and biophysical research communications

authors： Chen S,Osaki N,Shimotoyodome A

更新日期：2015-05-22 00:00:00

abstract：:BA1544 from Bacillus anthracis was previously annotated as a transcription factor for the gene cluster ba1554 - ba1558, but has not been experimentally characterized. B. anthracis is an obligate pathogen causing fatal inhalational anthrax, and BA1544 is absolutely conserved in Bacillus species, including Bacillus cere...

journal_title：Biochemical and biophysical research communications

authors： Kim MI,Hong M

更新日期：2016-03-25 00:00:00

abstract：:Protein cages have recently emerged as an extraordinary drug-delivery system due to its biocompatibility, biodegradability, low toxicity, ease to manipulate and engineer. We have reported earlier the formation and architecture of a do-decameric cage-like architecture of Vibrio cholerae acylphosphatase (VcAcP) at 3.1 Å...

journal_title：Biochemical and biophysical research communications

authors： Chatterjee S,Nath S,Sen U

更新日期：2020-03-05 00:00:00

abstract：:Fifteen pancreatic secretory proteins, including seven serine-endoproteinases (isoenzyme forms of trypsinogen, chymotrypsinogen and proelastase), four metallo-exoproteinases (isoenzymic forms of procarboxypeptidase A and procarboxypeptidase B), amylase, lipase, and two forms of carboxyl ester lipase were observed to a...

journal_title：Biochemical and biophysical research communications

authors： Freedman SD,Scheele GA

更新日期：1993-12-15 00:00:00

abstract：:Human follitropin receptor (hFSHR) cDNA was inserted into the genome of Autographa californica nuclear polyhedrosis virus under the control of the polyhedrin promoter. Spodoptera frugiperda (Sf9) insect cells expressed the hFSHR at the membrane level, 2-3 days after infection. Ligand binding analysis demonstrated satu...

journal_title：Biochemical and biophysical research communications

authors： Christophe S,Robert P,Maugain S,Bellet D,Koman A,Bidart JM

更新日期：1993-10-15 00:00:00