Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes.

abstract：:DmTTF is a Drosophila melanogaster mitochondrial DNA-binding protein which binds specifically to two homologous non-coding sequences located at the 3' ends of blocks of genes encoded on opposite strands. In order to test whether this protein acts as transcription termination factor, we assayed the capacity of DmTTF to...

journal_title：Biochemical and biophysical research communications

authors： Roberti M,Fernandez-Silva P,Polosa PL,Fernandez-Vizarra E,Bruni F,Deceglie S,Montoya J,Gadaleta MN,Cantatore P

更新日期：2005-05-27 00:00:00

abstract：:A novel human GPCR gene was cloned by PCR with degenerate primers designed from cannabinoid type 1 receptor (CB1) sequences and a full-length clone was isolated by screening of a human genomic DNA library. This gene, termed EDG-3, is highly homologous (51.9 % overall and 69.2 % in seven transmembrane regions) to human...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi F,Tokuda M,Hatase O,Brenner S

更新日期：1996-10-14 00:00:00

abstract：:The levels of the anti-aging protein α-Klotho, in its soluble form (s-Klotho), are depressed in the circulation of patients with type 1 diabetes (T1D) or type 2 diabetes (T2D). Gene transfer experiments have suggested a protective role for β-cell specific expression of α-Klotho in murine models of T1D and T1D, but the...

journal_title：Biochemical and biophysical research communications

authors： Prud'homme GJ,Glinka Y,Kurt M,Liu W,Wang Q

更新日期：2020-05-07 00:00:00

abstract：:Apoptosis is a mode of cell death characterized by chromatin condensation and disassembly of the nuclear lamina, processes that are also characteristic of mitosis. The apparent similarity between the two events, together with observations that apoptosis can occur following G2 arrest, has led to the suggestion that apo...

journal_title：Biochemical and biophysical research communications

authors： Norbury C,MacFarlane M,Fearnhead H,Cohen GM

更新日期：1994-08-15 00:00:00

abstract：:A few examples of translational activation by antisense small noncoding RNAs (sRNAs) have already been discovered in prokaryotic cells, and all of them are through a sense-antisense interaction at the 5'-untranslated region (5'-UTR) of target mRNAs. Here, we report a novel phenomenon of translational activation of pro...

journal_title：Biochemical and biophysical research communications

authors： Hayashi G,Hong C,Hagihara M,Nakatani K

更新日期：2012-12-07 00:00:00

abstract：:The present study was to investigate clinical significance, biological functions and underlying mechanisms of BTB Domain and CNC Homolog 1(BACH1) deregulation in human colorectal cancer (CRC). The result showed that BACH1 upregulation was significantly associated with enhanced tumor invasion (P = 0.014) and gender (P ...

journal_title：Biochemical and biophysical research communications

authors： Zhu GD,Liu F,OuYang S,Zhou R,Jiang FN,Zhang B,Liao WJ

更新日期：2018-05-05 00:00:00

abstract：:Enzyme-dependent mechanisms which prevent accumulation of chromanoxyl radicals derived from the vitamin E analogue, 2,2,5,7,8-pentamethyl-6-hydroxycromane (PMC), were characterized in rat liver microsomal and mitochondrial membranes. The free radical oxidation product of PMC (chromanoxyl radical) was generated in memb...

journal_title：Biochemical and biophysical research communications

authors： Packer L,Maguire JJ,Mehlhorn RJ,Serbinova E,Kagan VE

更新日期：1989-02-28 00:00:00

abstract：:We have demonstrated previously that patients with rheumatoid arthritis (RA) show an increase in serum and synovial fluid levels of complexes between alpha1-proteinase inhibitor (alpha1PI) and IgA. These are believed to form through disulfide binding between the Cys232 residue on alpha1PI and the penultimate cysteine ...

journal_title：Biochemical and biophysical research communications

authors： Scott LJ,Russell GI,Nixon NB,Dawes PT,Mattey DL

更新日期：1999-02-24 00:00:00

abstract：:The intrinsic fluorescence properties of human alpha apohemoglobin at protein concentrations from 1 to 5 microM in 0.1 M potassium phosphate buffer, pH 7 or 8 at 5 degrees C were monitored in the absence and presence of a fixed concentration (5 microM) of a fluorescence quenching heme-containing native or Des (146-His...

journal_title：Biochemical and biophysical research communications

authors： Chiu F,Vasudevan G,Morris A,McDonald MJ

更新日期：1998-01-14 00:00:00

abstract：:Platelets play essential roles in hemostasis and thrombosis by aggregating with each other. However, the molecular mechanism governing platelet aggregation is not yet fully understood. Here, we established an assay system using platelets permeabilized with streptolysin-O to analyze mechanism of the thrombin-induced ag...

journal_title：Biochemical and biophysical research communications

authors： Nishioka H,Horiuchi H,Tabuchi A,Yoshioka A,Shirakawa R,Kita T

更新日期：2001-02-02 00:00:00

abstract：:A significant percentage of the methyltransferasome in Saccharomyces cerevisiae and higher eukaryotes is devoted to methylation of the translational machinery. Methylation of the RNA components of the translational machinery has been studied extensively and is important for structure stability, ribosome biogenesis, an...

journal_title：Biochemical and biophysical research communications

authors： Al-Hadid Q,White J,Clarke S

更新日期：2016-02-12 00:00:00

abstract：:Dimerization of epidermal growth factor receptor (EGFR) leads to the activation of its tyrosine kinase. To elucidate whether dimerization is responsible for activation of the intracellular tyrosine kinase domain or just plays a role in the stabilization of the active form, the activated status of wild-type EGFR moiety...

journal_title：Biochemical and biophysical research communications

authors： Ge G,Wu J,Wang Y,Lin Q

更新日期：2002-01-25 00:00:00

abstract：:It has been suggested that curcumin and other sarcoplasmic/endoplasmic reticulum Ca(2+)-pump inhibitors could correct the defect in the most common mutation (DeltaF508) in cystic fibrosis (CF), and restore normal chloride transport. In the present study, the effect of curcumin was tested on baby hamster kidney (BHK) c...

journal_title：Biochemical and biophysical research communications

authors： Dragomir A,Björstad J,Hjelte L,Roomans GM

更新日期：2004-09-17 00:00:00

abstract：:The protein misfolding cyclic amplification (PMCA) assay allows for detection of prion protein misfolding activity in tissues and fluids from sheep with scrapie where it was previously undetected by conventional western blot and immunohistochemistry assays. Studies of goats with scrapie have yet to take advantage of P...

journal_title：Biochemical and biophysical research communications

authors： Madsen-Bouterse SA,Zhuang D,O'Rourke KI,Schneider DA

更新日期：2012-07-13 00:00:00

abstract：:Hematopoiesis is a complex process tightly controlled by sets of transcription factors in a context-dependent and stage-specific manner. Smad2/3 transcription factor plays a central role in differentiation and survival of erythroid cells. Here we report that follistatin-like 1 (FSTL1) treatment impairs hemin-induced e...

journal_title：Biochemical and biophysical research communications

authors： Wu J,Dong Y,Teng X,Cheng M,Shen Z,Chen W

更新日期：2015-10-30 00:00:00

abstract：:Estrogen is known to play a pivotal role in granulosa cell responses to follicle-stimulating hormone (FSH) that is critical for the establishment of dominant follicles and subsequent ovulation in mammals. Thus, elucidating the cellular and molecular mechanisms that regulate FSH activity is important to understand fema...

journal_title：Biochemical and biophysical research communications

authors： Miyoshi T,Otsuka F,Shimasaki S

更新日期：2013-05-03 00:00:00

abstract：:Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in m...

journal_title：Biochemical and biophysical research communications

authors： Kawai I,Hisaki T,Sugiura K,Naito K,Kano K

更新日期：2012-10-26 00:00:00

abstract：:Anthocyanins are critical for plants. It is shown that the expression of genes encoding the key enzymes such as dihydroflavonol 4-reductase (DFR), UDP-Glc: flavonoid 3-O-glucosyltransferase (UF3GT), and leucoanthocyanidin dioxygenase (LDOX) in anthocyanin biosynthesis pathway is regulated by MYB75, a R2R3 MYB transcri...

journal_title：Biochemical and biophysical research communications

authors： Li T,Jia KP,Lian HL,Yang X,Li L,Yang HQ

更新日期：2014-11-07 00:00:00

abstract：:Under standard conditions, in the presence of GTP, highly purified eIF-2 and Co-eIF-2 factor preparations efficiently stimulated AUG-codon dependent but not physiological mRNA-dependent Met-tRNAf binding to 40S ribosomes. Replacement of GTP by a nonhydrolyzable GTP analog, GMP-PNP, in the above system, gave significan...

journal_title：Biochemical and biophysical research communications

authors： Roy R,Nasrin N,Ahmad MF,Gupta NK

更新日期：1984-08-16 00:00:00

abstract：:Ubiquitin specific protease 39 (USP39) is one of the deubiquitinating enzymes without ubiquitin protease activity, which has been implicated in the progression of several cancers. However, the role of USP39 in pancreatic cancer (PC) is largely unknown. In present study, we found that USP39 expression was elevated in P...

journal_title：Biochemical and biophysical research communications

authors： Cai J,Liu T,Huang P,Yan W,Guo C,Xiong L,Liu A

更新日期：2017-04-22 00:00:00

abstract：:The secretory proteins from adrenal chromaffin granules, chromogranins A, A1 and A2, were found to be excellent in vitro methyl acceptor proteins. The purified protein-carboxyl methylase (PCM) from bovine erythrocytes incorporated 660, 2540 and 7890 pmol of methyl group/10 min/mg protein in chromogranins A, A1 and A2,...

journal_title：Biochemical and biophysical research communications

authors： Veeraragavan K,Coulombe R,Gagnon C

更新日期：1988-04-29 00:00:00

abstract：:The cyclin-dependent kinase (CDK) inhibitor p18 blocks progression of the cell cycle by associating with the cyclin D-dependent kinases CDK6 and CDK4. To better understand the regulation of p18 gene expression, we isolated full-length cDNA clones from a human BT-20 breast cancer cell cDNA library. These clones were th...

journal_title：Biochemical and biophysical research communications

authors： Blais A,Labrie Y,Pouliot F,Lachance Y,Labrie C

更新日期：1998-06-09 00:00:00

abstract：:ABCG2 (also called MXR (3), BCRP (4), or ABCP (5) is a recently-identified ABC half-transporter, which causes multidrug resistance in cancer. Here we report that the expression of the ABCG2 protein in Sf9 insect cells resulted in a high-capacity, vanadate-sensitive ATPase activity in isolated membrane preparations. AB...

journal_title：Biochemical and biophysical research communications

authors： Ozvegy C,Litman T,Szakács G,Nagy Z,Bates S,Váradi A,Sarkadi B

更新日期：2001-07-06 00:00:00

abstract：:We screened various isoprenoids to search for inducers of apoptosis-like cell death ("apoptosis") in the shoot primordia of Matricaria chamomilla and found that geraniol has the most potent apoptosis-inducing activity among terpenoids, as judged from DNA fragmentation in the cells. The apoptosis-inducing activity of g...

journal_title：Biochemical and biophysical research communications

authors： Izumi S,Takashima O,Hirata T

更新日期：1999-06-16 00:00:00

abstract：:The main objective of this study was to investigate the biological function of beta amyloid precursor protein (APP), in particular its nerve growth factor-like activity. We hypothesize that the extracellular domain containing the sequence RERMS, amino acids 328-332 of APP(695), represents the active site for this func...

journal_title：Biochemical and biophysical research communications

authors： Pawlik M,Otero DA,Park M,Fischer WH,Levy E,Saitoh T

更新日期：2007-04-20 00:00:00

abstract：:A comparison was made of cytosynalin- and MAPs-induced microtubule formation. Cytosynalin (a 35 kDa cytoskeleton-interacting and calmodulin-binding protein) facilitated more rapid and extensive microtubule formation than MAPs. Electron microscopic examination revealed that the cytosynalin-induced microtubules were 24 ...

journal_title：Biochemical and biophysical research communications

authors： Itoh K,Sobue K

更新日期：1987-07-31 00:00:00

abstract：:ATP binding cassette (ABC) transporters have a functional unit formed by two transmembrane domains and two nucleotide binding domains (NBDs). ATP-bound NBDs dimerize in a head-to-tail arrangement, with two nucleotides sandwiched at the dimer interface. Both NBDs contribute residues to each of the two nucleotide-bindin...

journal_title：Biochemical and biophysical research communications

authors： Zoghbi ME,Altenberg GA

更新日期：2014-01-03 00:00:00

abstract：:Cytochrome b5 has been shown to stimulate, inhibit or have no effect on catalysis by P450 cytochromes. Its action is known to depend on the isozyme of cytochrome P450, the substrate, and experimental conditions. Cytochrome P450 2B4 (CYP 2B4) has been used in our laboratory as a model isozyme to study the role of cytoc...

journal_title：Biochemical and biophysical research communications

authors： Zhang H,Myshkin E,Waskell L

更新日期：2005-12-09 00:00:00

abstract：:The translation terminator Sup35p assembles into self-replicating fibrillar aggregates that are responsible for the [PSI+] prion state. The Q/N-rich N-terminal domain together with the highly charged middle-domain (NM domain) drive the assembly of Sup35p into amyloid fibrils in vitro. NM domains are highly divergent a...

journal_title：Biochemical and biophysical research communications

authors： Kabani M,Melki R

更新日期：2020-08-27 00:00:00

abstract：:Histone deacetylase 6 (HDAC6) controls acetylation of a number of cytosolic proteins, most prominently tubulin. Tubacin is a small molecule inhibitor of HDAC6 selected for its selective inhibition of HDAC6 relative to other histone deacetylases. For this reason it has become a useful pharmacological tool to discern th...

journal_title：Biochemical and biophysical research communications

authors： Siow D,Wattenberg B

更新日期：2014-07-04 00:00:00