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Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling.

Abstract：

:Placental choriocarcinoma, a reproductive system carcinoma in women, has about 0.81% occurrence frequency in China, which leads to over 90% lethality due to indistinct pathogenesis and the absence of efficient therapeutic treatment. In the present study, using immunostaining and reverse transcription PCR, we reported that Dickkopf-1 (Dkk-1) is prominently expressed in human cytotrophoblast (CTB) cell, but absent in the human placental choriocarcinoma cell line JAR and JEG3, implicating an unknown correlation between Dkk-1 and carcinogenesis of placental choriocarcinoma. Further, through exogenous introduction of Dkk-1, we found repressed proliferation in JAR and JEG3, induced apoptosis in JAR, and discovered significant tumor suppression effects of Dkk-1 in placental choriocarcinoma. Moreover we found that this function of Dkk-1 is achieved through c-Jun N-terminal kinase (JNK), whereas the canonical Wnt pathway may not have a great role. This discovery is not symphonic to previous functional understanding of Dkk-1, a canonical Wnt signaling antagonist. Together, our data indicate the possible correlation between Dkk-1 and human placental choriocarcinoma and suggest potential applications of Dkk-1 in treatment of human placental choriocarcinomas.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Peng S,Miao C,Li J,Fan X,Cao Y,Duan E

doi

10.1016/j.bbrc.2006.09.087

subject

Has Abstract

pub_date

2006-11-24 00:00:00

pages

641-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)02132-2

journal_volume

350

pub_type

杂志文章

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