Oxidation-induced persistent activation of protein kinase C in hippocampal homogenates.

abstract：:Expression of the cytochrome P-450 monooxygenase activity 7-ethoxyresorufin O-deethylase (7-ERD) was surveyed in proliferating and quiescent cultures of murine cell line C-10, a non-tumorigenic line of presumed alveolar type II origin. 7-ERD activities were undetectable in subconfluent/proliferating cultures but becam...

journal_title：Biochemical and biophysical research communications

authors： Reiners JJ Jr,Pavone A,Cantu AR,Auerbach C,Malkinson AM

更新日期：1992-02-28 00:00:00

abstract：:Epidemiological data have shown that stress and other psychological factors might influence cancer onset and progression. However, to date, the mechanisms are not well understood. In the present study, we used chronic exposure to a scream as a novel form of sound stress to explore the influence of the chronic stress b...

journal_title：Biochemical and biophysical research communications

authors： Hou N,Zhang X,Zhao L,Zhao X,Li Z,Song T,Huang C

更新日期：2013-10-04 00:00:00

abstract：:Nuclear magnetic resonance (NMR) data directly indicated a Ca2+-dependent interaction between calmodulin (CaM) and CoDN3, a small effector of the plant pathogenic fungus Colletotrichum orbiculare, which is the causal agent of cucumber anthracnose. The overall conformation of CoDN3 is intrinsically disordered, and the ...

journal_title：Biochemical and biophysical research communications

authors： Isozumi N,Inoue Y,Imamura T,Mori M,Takano Y,Ohki S

更新日期：2019-06-30 00:00:00

abstract：:The effects of selective inhibition of cyclic AMP phosphodiesterase type III on insulin and glucose levels during an oral glucose challenge were evaluated in obese, diabetic ob/ob mice and in lean, non-diabetic littermates using the selective inhibitor, milrinone. Oral administration of milrinone increased plasma insu...

journal_title：Biochemical and biophysical research communications

authors： Parker JC,VanVolkenburg MA,Nardone NA,Hargrove DM,Andrews KM

更新日期：1997-07-30 00:00:00

abstract：:Electrophoretic mobility shift assays revealed minimal levels of NF-kappaB activity in rat distal lung epithelial cells cultured at fetal (23 mmHg) or adult alveolar (100 mmHg) P(O2), but revealed significant activation of this transcription factor in cells exposed to a rise in P(O2) mimicking that experienced at birt...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ,Collett A,Land SC,Olver RE,Wilson SM

更新日期：2001-03-09 00:00:00

abstract：:The budding yeast Saccharomyces cerevisiae contains a single actin gene and the gene product, actin, is essential for growth. Two mutants of yeast actin that do not support yeast growth were prepared from yeast by coexpressing the mutant and a 6-histidine-tagged wild-type actin followed by separation of the wild-type ...

journal_title：Biochemical and biophysical research communications

authors： Frieden C,Du J,Schriefer L,Buzan J

更新日期：2000-05-10 00:00:00

abstract：:Activation of protein kinase C has been shown to be involved in the activation pathway of many cell types. Recently, a number of investigations have suggested that protein kinase C plays an essential role in T lymphocyte activation. The recent synthesis of the protein kinase inhibitors, H-7 and HA1004, have now made p...

journal_title：Biochemical and biophysical research communications

authors： Clark RB,Love JT Jr,Sgroi D,Lingenheld EG,Sha'afi RI

更新日期：1987-06-15 00:00:00

abstract：:Triple A syndrome is an autosomal recessive neurological disease, mimicking motor neuron disease, and is caused by mutant ALADIN, a nuclear-pore complex component. We recently discovered that the pathogenesis involved impaired nuclear import of DNA repair proteins, including DNA ligase I and the cerebellar ataxia caus...

journal_title：Biochemical and biophysical research communications

authors： Kiriyama T,Hirano M,Asai H,Ikeda M,Furiya Y,Ueno S

更新日期：2008-10-03 00:00:00

abstract：:Receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily. RANKL increases endothelial permeability and induces angiogenesis, suggesting its critical roles in the vasculature. Despite the evidence implicating RANKL in vascular pathology, its role in ischemic retinopathy has not been previously repo...

journal_title：Biochemical and biophysical research communications

authors： Ock S,Park S,Lee J,Kim J

更新日期：2019-08-20 00:00:00

abstract：:The present study reports the presence of progesterone, testosterone and 17 beta-estradiol and their corresponding binding proteins in the reproductive system of Octopus vulgaris Lam (phylum Mollusca, subphylum Cephalopoda). These sex hormones occur in testis, vas deferens, seminal vesicle, prostate and Needham's sac....

journal_title：Biochemical and biophysical research communications

authors： D'Aniello A,Di Cosmo A,Di Cristo C,Assisi L,Botte V,Di Fiore MM

更新日期：1996-10-23 00:00:00

abstract：:Recent work identified an RNA binding protein whose presence in brain tumors correlated with translational repression of Glut1 expression. RNase T1 mapping demonstrated that this protein bound an AU-rich response element (AURE) in the Glut1 3'UTR. Facilitated by its differential expression in brain tumor cytosols, we ...

journal_title：Biochemical and biophysical research communications

authors： Hamilton BJ,Nichols RC,Tsukamoto H,Boado RJ,Pardridge WM,Rigby WF

更新日期：1999-08-11 00:00:00

abstract：:Mitochondrial pyruvate carrier (MPC), composed of MPC1 and MPC2, can modulate pyruvate oxidation in mitochondrial and MPC1 expression correlates with poor prognosis of multiple cancers. Here, we reported that MPC1 is acetylated and its main acetylation sites are: K45 and K46. Sirt3 binds to and deacetylates MPC1. High...

journal_title：Biochemical and biophysical research communications

authors： Liang L,Li Q,Huang L,Li D,Li X

更新日期：2015-12-25 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that is involved in DNA repair and activated by DNA damage. When activated, PARP-1 consumes NAD(+) to form ADP-ribose polymers on acceptor proteins. Extensive activation of PARP-1 leads to glycolytic blockade, energy failure, and cell death. These events have ...

journal_title：Biochemical and biophysical research communications

authors： Ying W,Garnier P,Swanson RA

更新日期：2003-09-05 00:00:00

abstract：:Resveratrol (trans-3,5,4'-trihydroxystilbene), a polyphenolic compound found largely in the skins of red grapes, has been used as a nutritional supplement or an investigational new drug for prevention of cardiovascular diseases. Previous reports showed that resveratrol had a protective effect against oxidative agent-i...

journal_title：Biochemical and biophysical research communications

authors： Leong CW,Wong CH,Lao SC,Leong EC,Lao IF,Law PT,Fung KP,Tsang KS,Waye MM,Tsui SK,Wang YT,Lee SM

更新日期：2007-08-17 00:00:00

abstract：:DR4, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor, is a key element in the extrinsic pathway of TRAIL/TRAIL receptor-related apoptosis that exerts a preferential toxic effect against tumor cells. However, TRAIL and DR4 are expressed in various normal cells, and recent studies indicate tha...

journal_title：Biochemical and biophysical research communications

authors： Kang MS,Lee SK,Park CS,Kang JH,Bae SH,Yu SL

更新日期：2008-11-14 00:00:00

abstract：:To study the effect of interleukin-6 (IL-6) on glucose transport, 2-deoxy-D-glucose (2-DOG) uptake in 3T3-L1 adipocytes after incubation with IL-6 was measured. IL-6 increased 2-DOG uptake maximally after 5 hours by 30 +/- 12%, with a half-maximal effect at an IL-6 concentration of approximately 800 U/mL. 3-O-methylgl...

journal_title：Biochemical and biophysical research communications

authors： Stouthard JM,Oude Elferink RP,Sauerwein HP

更新日期：1996-03-18 00:00:00

abstract：:v-Src activates gene expression mediated by serum response elements (SREs) and TPA response elements (TREs). v-Src-induced SRE- and TRE-mediated gene expressions are both dependent upon HaRas. Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that has been implicated in v-Src-initiated signals. We report...

journal_title：Biochemical and biophysical research communications

authors： Gupta R,Foster DA

更新日期：1994-12-15 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) cascades play an important role in regulation of AP-1 activity through the phosphorylation of distinct substrates. In the present study, we identified a novel protein, TMEM174, whose RNA transcripts are highly expressed in human kidney tissue. TMEM174 is comprised of 243 amino a...

journal_title：Biochemical and biophysical research communications

authors： Wang P,Sun B,Hao D,Zhang X,Shi T,Ma D

更新日期：2010-04-16 00:00:00

abstract：:We have constructed an expression plasmid for regulated expression of the hepatitis B surface antigen gene in yeast using promoter of the yeast Pho5 gene. In the yeast transformants, the monomeric HBsAg (22K dalton) was estimated to constitute approximately 3% of the total proteins. On extraction, the HBsAg was found ...

journal_title：Biochemical and biophysical research communications

authors： Choo KB,Wu SM,Lee HH,Lo SC

更新日期：1985-08-30 00:00:00

abstract：:Interleukin-1 alpha (IL-1 alpha) and interleukin-6 (IL-6), both known to be able to open the blood-brain barrier (BBB), downregulated plasma membrane-associated tyrosine phosphatase activity in primary porcine brain endothelial cells (PBEC). In contrast, transforming growth factor beta (TGF-beta) upregulated PTP activ...

journal_title：Biochemical and biophysical research communications

authors： Gloor SM,Weber A,Adachi N,Frei K

更新日期：1997-10-29 00:00:00

abstract：:We have cloned two cDNA isoforms as well as genomic sequences of the mouse Prx V gene and characterized their molecular genetic features. Two isoforms of the mouse Prx V cDNA were identified from liver and testis. The testis-originated long transcripts had extra 1164-bp 5'-UTR sequences compared to the liver-originate...

journal_title：Biochemical and biophysical research communications

authors： Lee TH,Kim SJ,Kang SW,Lee KK,Rhee SG,Yu DY

更新日期：2000-04-13 00:00:00

abstract：:It is now well established that PA is a potent biological response modifier, showing simultaneously antitumor, antitoxic, anticarcinogenic, antifungal, antiparasitic and immunomodulatory properties. Since PA is a foreign protein, it is quite logical to assume that it may be cleaved into smaller peptide fragments in vi...

journal_title：Biochemical and biophysical research communications

authors： Sinha P,Sengupta J,Ray PK

更新日期：1999-04-29 00:00:00

abstract：:A recent report has shown that in vitro the RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. However, in vivo, it is well known that CGRP receptors are expressed in human coronary arteries and that a beneficial effect is observed in patients after CGRP i...

journal_title：Biochemical and biophysical research communications

authors： Frayon S,Cueille C,Gnidéhou S,de Vernejoul MC,Garel JM

更新日期：2000-04-21 00:00:00

abstract：:Alpha-Galactosidase, the product of the melA gene, was purified from a strain of Escherichia coli harboring a plasmid carrying melA, which over-produced the alpha-galactosidase. An apparent molecular weight was determined to be 50 kDa. The amino acid composition of this enzyme was determined. The result indicates that...

journal_title：Biochemical and biophysical research communications

authors： Nagao Y,Nakada T,Imoto M,Shimamoto T,Sakai S,Tsuda M,Tsuchiya T

更新日期：1988-02-29 00:00:00

abstract：:The new potent tumor promoters teleocidin and debromoaplysiatoxin , which are structurally unrelated to phorbol esters, activate Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). The concentrations of 12-O-tetradecanoylphorbol-13-acetate, teleocidin and debromoaplysiatoxin for half-maximum acti...

journal_title：Biochemical and biophysical research communications

authors： Fujiki H,Tanaka Y,Miyake R,Kikkawa U,Nishizuka Y,Sugimura T

更新日期：1984-04-30 00:00:00

abstract：:The cobalt(II) derivative of cucumber basic blue copper protein "plantacyanin" has been prepared. The visible absorption, circular dichroic and magnetic circular dichroic spectra of Co(II)-plantacyanin are similar to those of Co(II)-plastocyanin, indicating that the stereochemistry of Co(II) is tetrahedral and at leas...

journal_title：Biochemical and biophysical research communications

authors： Sakurai T

更新日期：1986-09-30 00:00:00

abstract：:Telmisartan, an angiotensin II type 1 receptor blocker (ARB), attenuates hyperglycemia-aggravated vascular inflammation by decreasing IκB kinase β (IKKβ) expression in endothelial cells. Because glycogen synthase 3β (GSK3β) is involved in inflammatory process by regulating nuclear factor-κB (NF-κB) activity, we invest...

journal_title：Biochemical and biophysical research communications

authors： Song KH,Bae SJ,Chang J,Park JH,Jo I,Cho KW,Cho DH

更新日期：2017-09-30 00:00:00

abstract：:Neurotrophins are essential for the development and survival of catecholaminergic neurons. However, the critical pathway for expression of the tyrosine hydroxylase (TH) gene induced by neurotrophin is still unclear. Here we found that Ras/MEK pathway is required for NGF-induced expression of the TH gene in PC12D cells...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Kurahashi H,Ichinose H

更新日期：2004-03-05 00:00:00

abstract：:Pancreatic carcinoma is characterized by a poor prognosis and lack of response to conventional therapy. The regulatory mechanisms for the rapid proliferation of pancreatic cancer cells and the particular aggressiveness of this cancer are still not fully understood. In mammalian cells, three MAPK families including ERK...

journal_title：Biochemical and biophysical research communications

authors： Ding XZ,Adrian TE

更新日期：2001-03-30 00:00:00

abstract：:Besides its well-established oncosuppressor activity, the role of p53 in regulating metabolic pathways has been recently identified. Nevertheless, the function of p53 with respect to insulin resistance appears highly controversial. To address this issue, we investigated the expression of p53 in experimental model of i...

journal_title：Biochemical and biophysical research communications

authors： Geng S,Zhu W,Wang S,Xie C,Li X,Wu J,Li Y,Chen Y,Wang X,Meng Y,Zhang Q,Chen J,Zhong C

更新日期：2018-01-15 00:00:00