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The protein kinase C inhibitor H-7, inhibits antigen and IL-2-induced proliferation of murine T cell lines.

Abstract：

:Activation of protein kinase C has been shown to be involved in the activation pathway of many cell types. Recently, a number of investigations have suggested that protein kinase C plays an essential role in T lymphocyte activation. The recent synthesis of the protein kinase inhibitors, H-7 and HA1004, have now made possible a new approach for testing the relevance of protein kinase C in T cell activation and proliferation. We now report that the antigen-induced and interleukin-2-induced proliferation of murine T cell lines can be consistently inhibited by the protein kinase C inhibitor, H-7. HA1004, a somewhat more potent inhibitor of cyclic nucleotide-dependent protein kinases, but a significantly weaker inhibitor of protein kinase C than H-7, demonstrated no consistent inhibition of these T cell responses. These results represent a further demonstration that protein kinase C plays an essential role in the activation of T cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Clark RB,Love JT Jr,Sgroi D,Lingenheld EG,Sha'afi RI

doi

10.1016/0006-291x(87)91016-3

subject

Has Abstract

pub_date

1987-06-15 00:00:00

pages

666-72

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)91016-3

journal_volume

145

pub_type

杂志文章

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