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Prolonged modulation of FGF-2 expression in astrocytic cultures induced by O,O'-diacetyl-apomorphine.

Abstract：

:Apomorphine (APO) is an anti-parkinsonian drug currently in use, which provides relief of Parkinson's symptoms. However, the utility of APO is greatly hampered by its poor bioavailability and rapid metabolism. In the present study, O,O'-diacetyl-apomorphine, a prodrug of apomorphine, was synthesized and its biological activity was examined. The prodrug induced fibroblast growth factor-2 production in astrocytic cultures similarly to apomorphine. However, its duration of action was significantly prolonged, and its resistance to oxidation was markedly enhanced compared to APO. O,O'-Diacetyl-apomorphine also induced MEK/MAPK signaling. These results suggest that O,O'-diacetyl-apomorphine can efficiently counteract oxidation and thereby enhance FGF-2 production in astrocytes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

He X,Wang D,Zhang X,Li A,Gu X,Ding F,Zhou J

doi

10.1016/j.bbrc.2008.02.082

subject

Has Abstract

pub_date

2008-05-09 00:00:00

pages

824-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00358-6

journal_volume

369

pub_type

杂志文章

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