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Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin.

Abstract：

:Tyrosine protein kinase activity was measured in membranes from DMBA-induced mammary tumors, with Angiotensin II as substrate. The apparent Km for the peptide was 3.3 mM. This enzymatic activity is inhibited by Ca+2; Mn+2 can replace Mg+2 with an increase in the Km for ATP from 47 /microM to 172 microM. The enzymatic activity was not affected by cyclic AMP but was inhibited in dose dependent manner by quercetin, a bioflavonoid which is known to inhibit proliferation of malignant cells in vitro.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Levy J,Teuerstein I,Marbach M,Radian S,Sharoni Y

doi

10.1016/s0006-291x(84)80264-8

subject

Has Abstract

pub_date

1984-09-28 00:00:00

pages

1227-33

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)80264-8

journal_volume

123

pub_type

杂志文章

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