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Possible involvement of Hcn1 ion channel in learning and memory dysfunction in SAMP8 mice.

Abstract：

:The senescence-accelerated mouse prone 8 (SAMP8) strain exhibits age-related learning and memory deficits (LMD) at 2 months of age. Combined linkage analysis of 264 F2 intercross SAMP8 × JF1 mice and RNA-seq analysis identified Hcn1 gene out of 29 genes in the LMD region on chromosome 13. Hcn1 in SAMP8 strain showed 15 times less polyglutamine repetition compared to Japanese fancy mouse 1 (JF1). Whole cell patch clamp analysis showed that Hcn1 ion conductivity was significantly lower in SAMP8 compared to that of JF1, which may be associated with learning and memory deficiency.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Akbor MM,Tomobe K,Yamada T,Kim J,Mano H,Kurosawa N,Sasaki K,Nomura Y,Isobe M

doi

10.1016/j.bbrc.2013.09.145

subject

Has Abstract

pub_date

2013-11-08 00:00:00

pages

25-30

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)01666-5

journal_volume

441

pub_type

杂志文章

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