当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Phospholipase D is associated in a phorbol ester-dependent manner with protein kinase C-alpha and with a 220-kDa protein which is phosphorylated on serine and threonine.

Phospholipase D is associated in a phorbol ester-dependent manner with protein kinase C-alpha and with a 220-kDa protein which is phosphorylated on serine and threonine.

Abstract：

:Many studies have shown that phospholipase D (PLD) is activated by protein kinase C (PKC) in vivo and in vitro. In this study, a PLD isoform (rPLD1) was shown to bind to PKC-alpha in Rat1 fibroblasts treated with phorbol ester. The PKC-alpha binding domain of rPLD1 was localized to its N-terminus. The phospholipase was shown to become associated also with a 220-kDa protein (p220) in the fibroblasts and in Sf9 cells infected with recombinant baculovirus coding rPLD1. This interaction was increased by phorbol myristate acetate (PMA) treatment. p220 was phosphorylated on serine/threonine in PMA-stimulated Rat1 cells, and rPLD1 expressed in Sf9 cells was also serine/threonine phosphorylated in response to PMA treatment. These data suggest the PMA induces the formation of a RPLD1/PKC alpha/P220 complex in cells, some components of which undergo serine/threonine phosphorylation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Min DS,Exton JH

doi

10.1006/bbrc.1998.8990

subject

Has Abstract

pub_date

1998-07-30 00:00:00

pages

533-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)98990-2

journal_volume

248

pub_type

杂志文章

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