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Molecular cloning and sequence analysis of cDNA for human transferrin.

Abstract：

:A cDNA clone for human transferrin was identified from a human liver cDNA library by pre-screening with different ss-cDNA probes against length-fractionated liver mRNAs, positive hybridization-selection and nucleotide sequence analysis. The insert was of 1 kb, encoding human transferrin from aminoacid 403 through the COOH terminus, with a 3' non coding region of 166 nucleotides. This insert hybridized with a single major mRNA species of about 2.4 kb and several genomic DNA restriction fragments. Hybridization of the Southern blots with different parts of the transferrin insert and at different stringences suggest that the various bands observed correspond to splice sites inside one gene rather than to hybridization to several related genes. Finally, a single or a low number of transferrin gene copies seem to exist in the human genome.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Uzan G,Frain M,Park I,Besmond C,Maessen G,Trépat JS,Zakin MM,Kahn A

doi

10.1016/0006-291x(84)91648-6

subject

Has Abstract

pub_date

1984-02-29 00:00:00

pages

273-81

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(84)91648-6

journal_volume

119

pub_type

杂志文章

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