Abstract:
:The change of transferrin receptors in regenerating rat liver cells after partial hepatectomy was demonstrated. The binding of 125I-labeled transferrin to the cells began to increase after 24 h of partial hepatectomy and reached about double that of the non-operated normal rat liver cells. A Scatchard analysis of binding parameters showed 1.62 X 10(5) (Ka: 1.04 X 10(7) M-1) in normal cells and 3.36 X 10(5) (Ka: 1.23 X 10(7) M-1) in regenerating cells. This reflected on increase of transferrin receptor number and little change occurred in the binding affinity between transferrin and its surface receptor.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Tei I,Makino Y,Kadofuku T,Kanamaru I,Konno Kdoi
10.1016/0006-291x(84)90240-7subject
Has Abstractpub_date
1984-06-15 00:00:00pages
717-21issue
2eissn
0006-291Xissn
1090-2104pii
0006-291X(84)90240-7journal_volume
121pub_type
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