当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Mechanism of mannose toxicity.

Mechanism of mannose toxicity.

Abstract：

:Mannose toxicity in honeybees is due to a marked shortage of mannosephosphate isomerase that leads to a large accumulation of mannose-6-P and a marked depletion of ATP. Drosophila melanogaster and Ceratitis capitata are insensitive to mannose and have excess of mannosephosphate isomerase over hexokinase. 2-Deoxyglucose is as toxic as mannose for honeybees and is toxic also for the other insects studied, which supports the conclusion that the mechanism of mannose toxicity involves large accumulation of a hexosephosphate.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

de la Fuente M,Peñas PF,Sols A

doi

10.1016/0006-291x(86)91056-9

subject

Has Abstract

pub_date

1986-10-15 00:00:00

pages

51-5

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(86)91056-9

journal_volume

140

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo.

    abstract：:Thymoquinone (TQ), a component derived from the bioactive constituent of black seed (Nigella sativa), has been shown to exert biological activity on various types of human cancers. However, there are few studies addressing its effects on gastric cancer. Here, we present the first report describing the chemosensitizing...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.12.063

    authors： Lei X,Lv X,Liu M,Yang Z,Ji M,Guo X,Dong W

    更新日期：2012-01-13 00:00:00

  • An in vitro evaluation of the effects of homocysteine thiolactone on key steps of angiogenesis and tumor invasion.

    abstract：:Homocysteine thiolactone is a highly reactive homocysteine derivative that can react easily with proteins. Protein homocysteinylation has been suggested as a possible mechanism underlying the pathological consequences of impaired homocysteine metabolism. Homocysteine inhibits key steps of angiogenesis and tumor invasi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.10.044

    authors： Martínez-Poveda B,Chavarría T,Sánchez-Jiménez F,Quesada AR,Medina MA

    更新日期：2003-11-21 00:00:00

  • Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells.

    abstract：:Fibrosis is an abnormal response to organ injury, characterized by accumulation of activated fibroblasts at the sites of injury. Fibroblasts arise from several sources, including resident fibroblasts and circulating fibrocytes that infiltrate organ tissue. Recently, epithelial-mesenchymal transition (EMT) has been rec...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.10.097

    authors： Mikami Y,Yamauchi Y,Horie M,Kase M,Jo T,Takizawa H,Kohyama T,Nagase T

    更新日期：2012-11-30 00:00:00

  • Cytotoxicity of 6-biopterin to human melanocytes.

    abstract：:(6R)5,6,7,8 tetrahydrobiopterin (6-BH4) is an important cofactor in the regulation of melanogenesis in melanocytes, where it controls: (a) the supply of L-tyrosine from L-phenylalanine via phenylalanine hydroxylase, and (b) regulates directly dopaquinone formation from L-tyrosine via tyrosinase. 6-BH4 undergoes redox-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2423

    authors： Schallreuter KU,Büttner G,Pittelkow MR,Wood JM,Swanson NN,Körner C

    更新日期：1994-10-14 00:00:00

  • Identification of a novel growth hormone binding protein mRNA in rat liver.

    abstract：:The presence of highly specific serum binding proteins for growth hormone (GH) has been well characterized in many species. In the rat the major growth hormone-binding protein (GH-BP) is a truncated, variant form of the target tissue GH receptor and is derived by an alternative mRNA splicing event. The GHBP mRNA is co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81091-5

    authors： Tiong TS,Herington AC

    更新日期：1991-10-31 00:00:00

  • Circadian expression of clock and screening of clock-controlled genes in peripheral lymphocytes of rat.

    abstract：:In this paper, the circadian pattern of Clock and genes mediated by the Clock was investigated in peripheral lymphocytes of rats. Circadian rhythms of Clock are found under the regimes of constant darkness (DD) and 12-h light-12-h dark (LD12:12h), with the peak phase at CT7 and ZT21, respectively. Ten differential cDN...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.08.228

    authors： Du YZ,Fan SJ,Meng QH,Wang GQ,Tong J

    更新日期：2005-11-04 00:00:00

  • A novel insertion of a rearranged L1 element in exon 44 of the dystrophin gene: further evidence for possible bias in retroposon integration.

    abstract：:L1 elements are mammalian retrotransposons contributing to genome evolution and causing rare mutations in human. We describe a de novo insertion of an L1 element into the dystrophin gene resulting in skipping of exon 44 and causing Duchenne muscular dystrophy in a boy. The L1 element was rearranged due to the twin-pri...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.071

    authors： Musova Z,Hedvicakova P,Mohrmann M,Tesarova M,Krepelova A,Zeman J,Sedlacek Z

    更新日期：2006-08-18 00:00:00

  • Phosphorylated synaphin/complexin found in the brain exhibits enhanced SNARE complex binding.

    abstract：:The cytosolic protein synaphin/complexin critically regulates fast neurotransmitter release at the synapse by binding to SNARE complex. However, the exact mechanism of its action remains unclear, and very little is known about how it is physiologically regulated. Here we show that synaphins (Syps) 1 and 2 can be phosp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.01.064

    authors： Shata A,Saisu H,Odani S,Abe T

    更新日期：2007-03-16 00:00:00

  • Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH.

    abstract：:The xeroderma pigmentosum group A protein (XPA) binds to three nucleotide excision repair (NER) factors: RPA, ERCC1, and TFIIH. XPA also binds preferentially to UV- or chemical carcinogen-damaged DNA. In this study, we prepared anti-XPA monoclonal antibodies and examined their effects on NER. Two clones inhibited cell...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.07.030

    authors： Saijo M,Matsuda T,Kuraoka I,Tanaka K

    更新日期：2004-09-03 00:00:00

  • A-to-I RNA editing of the IGFBP7 transcript increases during aging in porcine brain tissues.

    abstract：:The IGFBP7 gene encodes insulin-like growth factor protein 7. IGFPB7 is involved in diverse biological functions including cell growth regulation, senescence and apoptosis, and also acts as a tumor suppressor in multiple cancers. The IGFBP7 mRNA is subject to A-to-I RNA editing mediated by adenosine deaminases acting ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.09.125

    authors： Larsen K,Kristensen KK,Momeni J,Farajzadeh L,Bendixen C

    更新日期：2016-10-21 00:00:00

  • Carboxyethyl gamma-aminobutyric acid, a polyamine derivative, improves the recovery of EBV-transformed lymphocytes.

    abstract：:A polyamine derivative, carboxyethyl - Aminobutyric Acid (CEGABA), induces the formation of a large number of Epstein-Barr Virus (EBV) transformed lymphocytes, when added to the culture medium immediately after EBV infection. However, CEGABA shows only a moderate effect on the stability of EBV-transformed cell lines o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90718-8

    authors： Cerino A,Bestagno M,Colonna M,Fussi F,Astaldi Ricotti GC

    更新日期：1988-02-15 00:00:00

  • PB1 and UBA domains of p62 are essential for aggresome-like induced structure formation.

    abstract：:ALIS are large, transient, cytosolic aggregates that serve as storage compartments for ubiquitin-tagged defective ribosomal products. We determined the importance of the protein p62 in the formation of ALIS and demonstrated that two domains of p62-PB1 and UBA-are essential for ALIS assembly. Those two major binding do...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.153

    authors： Cabe M,Rademacher DJ,Karlsson AB,Cherukuri S,Bakowska JC

    更新日期：2018-09-18 00:00:00

  • Increased free-cystine content of fibroblasts cultured from patients with cystinosis.

    abstract：:The presence of a significantly increased content of free-cystine in skin fibroblasts from both homozygotes and heterozygotes for cystinosis emphasizes the central role of cystine in this disease, even though the primary defect responsible for cystine accumulation is yet to be determined. The studies described in this...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(67)90516-5

    authors： Schneider JA,Rosenbloom FM,Bradley KH,Seegmiller JE

    更新日期：1967-11-30 00:00:00

  • Activation of mutant protein kinase Cgamma leads to aberrant sequestration and impairment of its cellular function.

    abstract：:Mutations in protein kinase Cgamma (PKCgamma) cause the neurodegenerative disease spinocerebellar ataxia type 14 (SCA14). In this study, expression of an extensive panel of known SCA14-associated PKCgamma mutations as fusion proteins in cell culture led to the consistent formation of cytoplasmic aggregates in response...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.072

    authors： Doran G,Davies KE,Talbot K

    更新日期：2008-08-01 00:00:00

  • Lipid selectivity in detergent extraction from bilayers.

    abstract：:Despite numerous studies on detergent-induced solubilization of membranes and on the underlying mechanisms associated with this process, very little is known regarding the selectivity of detergents for lipids during their extraction from membranes. To get insights about this phenomenon, solubilization of model bilayer...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.07.065

    authors： Azouz M,Therrien A,Buré C,Tokarski C,Lecomte S,Lafleur M

    更新日期：2020-10-15 00:00:00

  • A p53-inducible microRNA-34a downregulates Ras signaling by targeting IMPDH.

    abstract：:p53 is a well-known transcription factor that controls cell cycle arrest and cell death in response to a wide range of stresses. Moreover, p53 regulates glucose metabolism and its mutation results in the metabolic switch to the Warburg effect found in cancer cells. Nucleotide biosynthesis is also critical for cell pro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.01.077

    authors： Kim HR,Roe JS,Lee JE,Hwang IY,Cho EJ,Youn HD

    更新日期：2012-02-24 00:00:00

  • Vitamin A regulates the expression of apolipoprotein AI and CIII genes in the rat.

    abstract：:The effect of vitamin A on the expression of apoAI and CIII genes in intact rats was studied. In vitamin A-deficient rats, the hepatic level of apoAI mRNA was increased and enhanced by an oral administration of excess retinoic acid(RA). A similar administration to normal rats caused an increase in the apoAI mRNA level...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2838

    authors： Nagasaki A,Kikuchi T,Kurata K,Masushige S,Hasegawa T,Kato S

    更新日期：1994-12-30 00:00:00

  • The effect of copper chelating drugs on liver iron mobilization in the adult rat.

    abstract：:To test the hypothesis that ferroxidase I (ceruloplasmin) activity is essential for iron mobilization, adult rats were fed a copper sufficient diet with or without the chelating drugs D-penicillamine and triethylenetetramine for 120 days. By day 6 of treatment and for the remainder of the experiment the drug-fed rats ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90441-2

    authors： Cohen NL,Keen CL,Lönnerdal B,Hurley LS

    更新日期：1983-05-31 00:00:00

  • Receptors for insulin interact with Gi-proteins and for epidermal growth factor with Gi- and Gs-proteins in rat pancreatic acinar cells.

    abstract：:In rat pancreatic acinar cells epidermal growth factor (EGF) and insulin increase both basal and cholecystokinin (CCK-OP) stimulated amylase release in vitro (1) as a long term function of this tissue. Here we show that preincubation of isolated plasma membranes with EGF or with insulin leads to increased incorporatio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91575-w

    authors： Pröfrock A,Schnefel S,Schulz I

    更新日期：1991-03-15 00:00:00

  • Thylakoid-bound chloroplast DNA from spinach is enriched for replication forks.

    abstract：:Chloroplast DNA is bound to the thylakoids of spinach chloroplasts. To examine a possible role for thylakoid-bound DNA in chloroplast DNA replication, vesicles formed by treating chloroplasts in 3.5 mM MgCl2 were used. Chloroplast DNA fragments are bound to the surface of these vesicles. Chloroplast DNA isolated from ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80194-9

    authors： Lindbeck AG,Rose RJ

    更新日期：1990-10-15 00:00:00

  • Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia.

    abstract：:Heme oxygenase-1 (HO-1) is an inducible form of heme oxygenase that catabolizes heme to carbon monoxide, biliverdin, and ferrous iron. We have investigated whether HO-1 can induce angiogenic effects in vivo. Rats were subjected to a bolus injection of either wild type adenovirus (ad-wt) or adenovirus encoding HO-1 (ad...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00114-1

    authors： Suzuki M,Iso-o N,Takeshita S,Tsukamoto K,Mori I,Sato T,Ohno M,Nagai R,Ishizaka N

    更新日期：2003-02-28 00:00:00

  • Cleavage of recombinant enkephalin precursor by endoproteolytic activity in bovine chromaffin granules.

    abstract：:To identify endoproteolytic activity that processes the enkephalin precursor, a novel approach was undertaken for the production of model substrate in the form of recombinant 35S-(Met)-preproenkephalin (35S-(Met)-PPE), generated by in vitro transcription and translation of the rat PPE cDNA. Endoproteolytic activity in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)92085-e

    authors： Hook VY,Hegerle D,Affolter HU

    更新日期：1990-03-16 00:00:00

  • Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells.

    abstract：:Human CCL23 (also known as CKbeta8, MPIF-1, or MIP-3) has been recently reported to induce endothelial cell migration and tube formation via CCR1. Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix and also appear to play critical roles in angiogenesis. In the present study, w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.037

    authors： Son KN,Hwang J,Kwon BS,Kim J

    更新日期：2006-02-10 00:00:00

  • Heme initiates changes in the expression of a wide array of genes during the early erythroid differentiation stage.

    abstract：:Heme is central to oxygen sensing and utilization in all living organisms. It directly regulates numerous molecular and cellular processes for systems that sense or use oxygen. In mammals, heme plays an indispensable role in erythroid cell differentiation. To investigate heme regulatory functions, we identified, by di...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0586

    authors： Zhu Y,Hon T,Zhang L

    更新日期：1999-04-29 00:00:00

  • Covalent conjugation of Groucho with SUMO-1 modulates its corepressor activity.

    abstract：:Groucho is a corepressor that forms a macromolecular complex for its corepressor activity, in which HDAC1 is an essential component for the modulation of chromatin structure and transcriptional repression of target genes. Here, we show that Groucho is covalently conjugated with small ubiquitin-related modifier-1 (SUMO...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.12.043

    authors： Ahn JW,Lee YA,Ahn JH,Choi CY

    更新日期：2009-01-30 00:00:00

  • Protein kinase C activation increases binding of transcription factor PU.1 in murine tissue macrophages.

    abstract：:PU.1 is a transcription factor found in macrophages, B cells, neutrophils, and hemopoietic stem cells. In macrophages PU.1 regulates a number of genes, including c-fms, CD11b, CD18, and FcgammaR1b. Previously, in primary macrophages PU.1 binding to the sequence GAGGAA was found to be induced by treatment with bacteria...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9905

    authors： Xue Y,Alford P,Shackelford RE

    更新日期：1999-01-08 00:00:00

  • Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers.

    abstract：:Carcinogenesis is a long process that results in the accumulation of genetic alterations primarily in genes involved in the regulation of signalling pathways relevant for the regulation of cell growth and the cell cycle. Alteration of additional genes regulating cell adhesion and migration, angiogenesis, apoptosis, an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)00920-8

    authors： Ramírez de Molina A,Rodríguez-González A,Gutiérrez R,Martínez-Piñeiro L,Sánchez J,Bonilla F,Rosell R,Lacal J

    更新日期：2002-08-23 00:00:00

  • Synergistic potentiation of thiazolidinedione-induced ST 13 preadipocyte differentiation by RAR synergists.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPAR gamma) belongs to a nuclear receptor super family that functions as a master regulator of adipocyte differentiation. PPAR gamma binds its DNA response element together with a partner, retinoid X receptor (RXR), in fat cells. Five RXR ligands (HX600, HX630, DA022, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.4172

    authors： Sato M,Yajima Y,Kawashima S,Tanaka K,Kagechika H

    更新日期：2001-01-26 00:00:00

  • Mouse lymphomas caused by an intron-splicing donor site deletion of the FasL gene.

    abstract：:A spontaneous lymphoma was detected in mice, which was caused by a recessive autosomal mutation. The genetic basis was revealed to be a 5-bp deletion at the splicing donor site of the first intron of the FasL gene, resulting in aberrant transcripts coding for non-functional proteins. This mutation of the FasL gene cau...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.07.215

    authors： Wang CC,Zeng Q,Hwang LA,Guo K,Li J,Liew HC,Hong W

    更新日期：2006-10-13 00:00:00

  • A splice junction mutation in the alpha(M) gene of phosphorylase kinase in a patient with myopathy.

    abstract：:In a 28-year-old man with myopathy and phosphorylase kinase (PhK) deficiency, we found a G-to-C substitution at the 5' end of an intron in the muscle-specific alpha-subunit gene. The mutation destroys the high-consensus GT sequences at the 5' splice junction of the intron, which causes skipping of the preceding exon. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9211

    authors： Bruno C,Manfredi G,Andreu AL,Shanske S,Krishna S,Ilse WK,DiMauro S

    更新日期：1998-08-28 00:00:00