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Mouse lymphomas caused by an intron-splicing donor site deletion of the FasL gene.

Abstract：

:A spontaneous lymphoma was detected in mice, which was caused by a recessive autosomal mutation. The genetic basis was revealed to be a 5-bp deletion at the splicing donor site of the first intron of the FasL gene, resulting in aberrant transcripts coding for non-functional proteins. This mutation of the FasL gene caused development of lymphoma in all four mouse genetic backgrounds tested and the lymphoma was characterized by an expansion of leucocytes that were TCR+CD3+B220+CD19-CD4-CD8-. Accordingly, severe splenomegaly developed in the mutant mice. Interestingly, thymic hyperplasia was observed in mutant mice at later stages. These results underscore the functional importance of the splicing donor site in the function of the FasL gene and provide an independent evidence for a role of FasL in normal development of lymophocytes. The mutant mice offer another genetically defined mouse model for further studies of the role and mechanism of action of FasL.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang CC,Zeng Q,Hwang LA,Guo K,Li J,Liew HC,Hong W

doi

10.1016/j.bbrc.2006.07.215

subject

Has Abstract

pub_date

2006-10-13 00:00:00

pages

50-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)01693-7

journal_volume

349

pub_type

杂志文章

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