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PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans.

Abstract：

:Deinococcus radiodurans exhibits an extraordinary ability to withstand the lethal and mutagenic effects of DNA damaging agents, particularly, ionizing radiation. Available evidence indicates that efficient repair of DNA damage and protection of the chromosomal structure are mainly responsible for the radioresistance. Little is known about the biochemical basis for this phenomenon. We have identified a unique gene, pprI, as a general switch for downstream DNA repair and protection pathways, from a natural mutant, in which pprI is disrupted by a transposon. Complete functional disruption of the gene in wild-type leads to dramatic sensitivity to ionizing radiation. Radioresistance of the disruptant could be fully restored by complementation with pprI. In response to radiation stress, PprI can significantly and specifically induce the gene expression of recA and pprA and enhance the enzyme activities of catalases. These results strongly suggest that PprI plays a crucial role in regulating multiple DNA repair and protection pathways in response to radiation stress.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hua Y,Narumi I,Gao G,Tian B,Satoh K,Kitayama S,Shen B

doi

10.1016/s0006-291x(03)00965-3

subject

Has Abstract

pub_date

2003-06-27 00:00:00

pages

354-60

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X03009653

journal_volume

306

pub_type

杂志文章

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