Modulation of rat liver protein kinase C during "in vivo" CC14-induced oxidative stress.

abstract：INTRODUCTION:Chemical intervention of autophagy has been investigated in clinical trials for various age-related conditions such as sarcopenia and neurodegeneration. However, at present, no autophagy inducer has been established as a disease-modifying agent against neurodegenerative diseases. METHODS:We screened a lib...

journal_title：Biochemical and biophysical research communications

authors： Hirano K,Fujimaki M,Sasazawa Y,Yamaguchi A,Ishikawa KI,Miyamoto K,Souma S,Furuya N,Imamichi Y,Yamada D,Saya H,Akamatsu W,Saiki S,Hattori N

更新日期：2019-10-08 00:00:00

abstract：:Hyperphosphorylation of extracellular signal-regulated protein kinases-1/2 (ERK1/2) is known to promote cancer cell proliferation. We therefore investigated the constitutive phosphorylation levels of ERK1/2 and the expression of its downstream targets c-Fos, c-Jun, and cyclooxygenase-2 (COX-2) in biopsied human gastri...

journal_title：Biochemical and biophysical research communications

authors： Wu WK,Sung JJ,Yu L,Li ZJ,Chu KM,Cho CH

更新日期：2008-08-22 00:00:00

abstract：:Adrenomedullin (AM) gains its bioactivity by amidation at its C-terminal, forming "mature AM." The mature AM and the expression of AM receptor component mRNAs, receptor activity-modifying protein 2 and calcitonin receptor-like receptor, from feto-maternal tissues of normal pregnant women and women with histologic chor...

journal_title：Biochemical and biophysical research communications

authors： Makino I,Makino Y,Yoshihara F,Nishikimi T,Kawarabayashi T,Kangawa K,Shibata K

更新日期：2003-02-07 00:00:00

abstract：:G-quadruplex is one of the best-studied non-B type DNA that is now known to be prevalently present in the genomes of almost all the biological species. Recent studies reveal roles of G-quadruplex (G4) structures in various nucleic acids and chromosome transactions. In this short article, we will first describe recent ...

journal_title：Biochemical and biophysical research communications

authors： Masai H,Tanaka T

更新日期：2020-10-08 00:00:00

abstract：:Recently, we reported that in various cell lines under conditions of deenergization of the mitochondrial membrane, the release of Ca(2+) from the endoplasmic reticulum (ER) does not produce the expected activation of store-operated calcium channels (SOCs) in the plasma membrane. In the present work, we examined the ac...

journal_title：Biochemical and biophysical research communications

authors： Wasniewska M,Karczmarewicz E,Pronicki M,Piekutowska-Abramczuk D,Zablocki K,Popowska E,Pronicka E,Duszyński J

更新日期：2001-05-11 00:00:00

abstract：:CYP27A1 catalyses hydroxylations in the biosynthesis of bile acids and the bioactivation of vitamin D3. We investigated the expression of CYP27A1 in human monocytes, monocyte-derived macrophages, and dendritic cells on mRNA and protein levels as well as its enzymatic activity in comparison with the expression of CYP27...

journal_title：Biochemical and biophysical research communications

authors： Gottfried E,Rehli M,Hahn J,Holler E,Andreesen R,Kreutz M

更新日期：2006-10-13 00:00:00

abstract：:The cDNA encoding Mn peroxidase isozyme H4 from Phanerochaete chrysosporium was recombined into a baculovirus and heterologously expressed in Sf9 cells. The recombinant Mn peroxidase has the same molecular weight as the native enzyme as determined by SDS-PAGE and cross-reacts with a Mn peroxidase-specific antibody. Th...

journal_title：Biochemical and biophysical research communications

authors： Pease EA,Aust SD,Tien M

更新日期：1991-09-16 00:00:00

abstract：:MazF is a sequence-specific endoribonuclease or mRNA interferase, which cleaves RNA at a specific sequence. Since the expression of a specific gene or a group of specific genes can be regulated by MazF, expanding the repertoire of recognition sequences by MazF mRNA interferases is highly desirable for biotechnological...

journal_title：Biochemical and biophysical research communications

authors： Ishida Y,Inouye K,Ming O,Inouye M

更新日期：2019-10-20 00:00:00

abstract：:Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP- ribosylation enzyme and plays important roles in a variety of cellular processes, including DNA damage response and tumor development. However, the post-transcriptional regulation of PARP1 remains largely unknown. In this study, we identified that the mRNA of PARP1 is ...

journal_title：Biochemical and biophysical research communications

authors： Song D,Huang H,Wang J,Zhao Y,Hu X,He F,Yu L,Wu J

更新日期：2017-06-17 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are newly identified, potent producers of type 2 cytokines, such as IL-5 and IL-13, and contribute to the development of allergic lung inflammation induced by cysteine proteases. Although it has been shown that inducible costimulator (ICOS), a costimulatory molecule, is expressed ...

journal_title：Biochemical and biophysical research communications

authors： Kamachi F,Isshiki T,Harada N,Akiba H,Miyake S

更新日期：2015-08-07 00:00:00

abstract：:The lipase from Malassezia globosa (SMG1) was identified to be strictly specific for mono- and diacylglycerol but not triacylglycerol. The crystal structures of SMG1 were solved in the closed conformation, but they failed to provide direct evidence of factors responsible for this unique selectivity. To address this pr...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Gao C,Lan D,Yang B,Wang Y

更新日期：2012-07-27 00:00:00

abstract：:Bovine retinal rod outer segment membranes are enriched in a phosphoinositide-specific phosphodiesterase (phospholipase C) activity strictly modulated by free calcium ion concentration. The enzyme(s) was highly active on phosphatidylinositol 4,5-bisphosphate: maximal hydrolysis rate was attained at 10(-5)M Ca2+ and ac...

journal_title：Biochemical and biophysical research communications

authors： Panfoli I,Morelli A,Pepe I

更新日期：1990-11-30 00:00:00

abstract：:Mesenchymal stem cells (MSCs) isolated from several adult human tissues are reported to be a promising tool for regenerative medicine. In order to broaden the array of tools for therapeutic application, we isolated a new population of cells from adult human testis termed gonadal stem cells (GSCs). GSCs express CD105, ...

journal_title：Biochemical and biophysical research communications

authors： Gonzalez R,Griparic L,Vargas V,Burgee K,Santacruz P,Anderson R,Schiewe M,Silva F,Patel A

更新日期：2009-08-07 00:00:00

abstract：:Inhibitors of poly(ADP-ribose) synthetase, namely nicotinamide, benzamide, m-methoxybenzamide and 3-aminobenzamide, augmented chondrocytic differentiation chick embryo limb bud mesenchymal cells, in culture. These inhibitors stimulated early appearance and massive formation of cartilage nodules in micromass cultures s...

journal_title：Biochemical and biophysical research communications

authors： Nishio A,Nakanishi S,Doull J,Uyeki EM

更新日期：1983-03-16 00:00:00

abstract：:We developed a method for site-selective CpG methylation of the budding yeast genome. The method recruits LexA-fused M.SssI DNA methyltransferase to LexA operator sequences integrated adjacent to the target site. Microarray analysis of methylated DNAs indicated that the tethered enzyme selectively methylates the regio...

journal_title：Biochemical and biophysical research communications

authors： Feng SY,Ota K,Yamada Y,Sawabu N,Ito T

更新日期：2004-01-23 00:00:00

abstract：:The various manipulations involved in the isolation of membrane fragments from culture fluids of murine melanoma cells were examined to discern their effect on membrane fragment structure. Ultracentrifugation and gel chromatography were compared using the presence of marker enzymes and the sensitivity to a non-ionic d...

journal_title：Biochemical and biophysical research communications

authors： Taylor DD,Chou IN,Black PH

更新日期：1983-06-15 00:00:00

abstract：:Apolipoprotein (apo-) B mRNA editing at nucleotide 6666 converts cytidine to uridine, transforming the codon for glutamine-2153 to a termination codon. To investigate this editing mechanism, [a-32P] and [5-3H] CTP were incorporated into synthetic apo-B RNA. After the substrate had been edited extensively in vitro by a...

journal_title：Biochemical and biophysical research communications

authors： Johnson DF,Poksay KS,Innerarity TL

更新日期：1993-09-30 00:00:00

abstract：:miR-183 cluster, composed of miR-183/-96/-182 genes, is highly expressed in the adult retina, particularly in photoreceptors. It involves in development, maturation and normal function of neuroretina. Ectopic overexpression of miR-183/-96/-182 genes was performed to assess reprogramming of hRPE cells. They were amplif...

journal_title：Biochemical and biophysical research communications

authors： Davari M,Soheili ZS,Samiei S,Sharifi Z,Pirmardan ER

更新日期：2017-01-29 00:00:00

abstract：:Endothelial argininosuccinate synthetase 1 (ASS1) regulates the provision of l-arginine to nitric oxide synthase 3 (NOS3). Previous studies demonstrated that endothelial ASS1 expression was induced by laminar shear stress (LSS) and that this enzyme plays a role in maintaining anti-inflammatory microenvironments throug...

journal_title：Biochemical and biophysical research communications

authors： Mun GI,Boo YC

更新日期：2012-04-06 00:00:00

abstract：:In this study, a new skin-depigmenting agent, 2,6-dimethoxy-N-(4-methoxyphenyl)benzamide (DMPB), was synthesized using a combination of benzoic acid and aniline. DMPB exhibited significant depigmentation ability on the UV B-induced hyperpigmentation of the brown guinea pig skin. In addition, the 100ppm treatment with ...

journal_title：Biochemical and biophysical research communications

authors： Choi SY,Hwang JS,Kim S,Kim SY

更新日期：2006-10-13 00:00:00

abstract：:RNA interference is rapidly becoming a powerful tool for gene silencing in mammalian cells. Introduction of siRNA into primary cells, however, remains one of the major difficulties of this novel technique. Using cationic lipid-based transfection reagents satisfactory transfection results are observed in cell lines, bu...

journal_title：Biochemical and biophysical research communications

authors： Lingor P,Michel U,Schöll U,Bähr M,Kügler S

更新日期：2004-03-19 00:00:00

abstract：:Hypoxia inducible factor-1 (HIF-1) is a transcription factor composed of two subunits, HIF-1alpha and ARNT, which is activated under hypoxia. HIF-1alpha mRNA is expressed constitutively in a wide variety of cell types, whereas in some others HIF1A gene expression is upregulated by hypoxia. In this report, we show that...

journal_title：Biochemical and biophysical research communications

authors： Minet E,Ernest I,Michel G,Roland I,Remacle J,Raes M,Michiels C

更新日期：1999-08-02 00:00:00

abstract：:Reaction of metmyoglobin with peroxides is known to involve the formation, possibly via a porphyrin radical-cation, of a ferryl (iron(IV)-oxo) species and a protein radical; there is a little information available as to which of these species initiates the damage which is observed on incubating membrane fractions with...

journal_title：Biochemical and biophysical research communications

authors： Newman ES,Rice-Evans CA,Davies MJ

更新日期：1991-09-30 00:00:00

abstract：:We have purified from beef liver an enzyme which decarbamoylates carbamoyl-hemoglobin and to a much lesser extent carbamoyl histones. Carbamoyl casein was a poor substrate while carbamoyl trypsin, fibrinogen and ovoalbumin were not affected. The optimal pH is 7.4. Addition of Mg++, Mn++ or Ca++ was without effect. On ...

journal_title：Biochemical and biophysical research communications

authors： Costell M,Grisolía S

更新日期：1985-04-16 00:00:00

abstract：:It is known that the first step in the de novo synthesis of tetrahydrobiopterin from GTP is the conversion of GTP to dihydroneopterin triphosphate. Recent evidence supports the conclusion that beyond this first step, the pterin intermediates in the pathway are all at the tetrahydro level of reduction. We have now show...

journal_title：Biochemical and biophysical research communications

authors： Milstien S,Kaufman S

更新日期：1985-05-16 00:00:00

abstract：:The serine proteinase catalyzed hydrolysis of N-ethoxycarbonyl-D-phenylalanyl-L-prolyl-alpha-azalysine p- nitrophenyl ester (Eoc-D-Phe-Pro-azaLys-ONp) was investigated at pH 6.2 and 21.0 degrees C. The results are consistent with the minimum three-step catalytic mechanism. The acylation step is rate limiting for human...

journal_title：Biochemical and biophysical research communications

authors： Balliano G,Milla P,Giordano C,Gallina C,Coletta M,Menegatti E,Rizzi M,Bolognesi M,Ascenzi P

更新日期：1996-08-14 00:00:00

abstract：:The jelly coat of echinoderm eggs contains a glycoconjugate, acrosome reaction-inducing substance (ARIS), that is essential for triggering the acrosome reaction in homologous spermatozoa. In the starfish, Asterias amurensis, ARIS is a sulfated glycoprotein of an apparent molecular size of greater than 10(7). Since its...

journal_title：Biochemical and biophysical research communications

authors： Okinaga T,Ohashi Y,Hoshi M

更新日期：1992-07-15 00:00:00

abstract：:In hematopoietic cells, Ras has been implicated in signaling pathways that prevent apoptosis triggered by deprivation of cytokines, such as interleukin-3 (IL-3). However, the mechanism whereby Ras suppresses cell death remains incompletely understood. We have investigated the role of Ras in IL-3 signal transduction by...

journal_title：Biochemical and biophysical research communications

authors： Terada K,Kaziro Y,Satoh T

更新日期：2000-01-07 00:00:00

abstract：:Although the neuron-restrictive silencer element (NRSE/Regard) has been shown to function as a negative-acting DNA regulatory element to prevent the expression of neuron-specific genes in non-neuronal cells, little is known about its silencing effect on transcription in primary glial cells nor its effect on transcript...

journal_title：Biochemical and biophysical research communications

authors： Tabuchi A,Nakatani C,Nakaoka R,Naruse Y,Kojima T,Mori N,Tsuda M

更新日期：1999-08-02 00:00:00

abstract：:Starch branching enzyme (SBE) catalyzes the cleavage of α-1,4-linkages and the subsequent transfer of α-1,4 glucan to form an α-1,6 branch point in amylopectin. We determined the crystal structure of the rice branching enzyme I (BEI) in complex with maltopentaose at a resolution of 2.2Å. Maltopentaose bound to a hydro...

journal_title：Biochemical and biophysical research communications

authors： Chaen K,Noguchi J,Omori T,Kakuta Y,Kimura M

更新日期：2012-08-03 00:00:00