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G-quadruplex DNA and RNA: Their roles in regulation of DNA replication and other biological functions.

Abstract：

:G-quadruplex is one of the best-studied non-B type DNA that is now known to be prevalently present in the genomes of almost all the biological species. Recent studies reveal roles of G-quadruplex (G4) structures in various nucleic acids and chromosome transactions. In this short article, we will first describe recent findings on the roles of G4 in regulation of DNA replication. G4 is involved in regulation of spatio-temporal regulation of DNA replication through interaction with a specific binding protein, Rif1. This regulation is at least partially mediated by generation of specific chromatin architecture through Rif1-G4 interactions. We will also describe recent studies showing the potential roles of G4 in initiation of DNA replication. Next, we will present showcases of highly diversified roles of DNA G4 and RNA G4 in regulation of nucleic acid and chromosome functions. Finally, we will discuss how the formation of cellular G4 could be regulated.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Masai H,Tanaka T

doi

10.1016/j.bbrc.2020.05.132

subject

Has Abstract

pub_date

2020-10-08 00:00:00

pages

25-38

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)31061-5

journal_volume

531

pub_type

杂志文章

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