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DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway.

Abstract：

:Diacylglycerol kinase (DGK) plays an important role in phosphoinositide signaling cascade by regulating the intracellular level of diacylglycerol and phosphatidic acid. The DGK family is involved in various pathophysiological responses that are mediated through unique binding partners in different tissues and cells. In this study, we identified a small GTPase effector protein, IQGAP1, as a novel DGKζ-associated complex protein. A bacterial endotoxin, lipopolysaccharide (LPS), facilitated the complex formation in macrophages. Both proteins co-localized at the edge and phagocytic cup of the cell. Furthermore, RNA interference-mediated knockdown of DGKζ or IQGAP1 impaired LPS-induced Rac1 activation. Primary macrophages derived from DGKζ(-/-) mice attenuated LPS-induced phagocytosis of bacteria. These results suggest that DGKζ is involved in IQGAP1/Rac1-mediated phagocytosis upon LPS stimulation in macrophages.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Okada M,Hozumi Y,Iwazaki K,Misaki K,Yanagida M,Araki Y,Watanabe T,Yagisawa H,Topham MK,Kaibuchi K,Goto K

doi

10.1016/j.bbrc.2012.03.057

subject

Has Abstract

pub_date

2012-04-06 00:00:00

pages

479-84

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)00504-9

journal_volume

420

pub_type

杂志文章

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