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Trans-activation of herpes simplex virus type 1 immediate early genes is specifically inhibited by human recombinant interferons.

Abstract：

:The effect of human recombinant interferons (IFNs) alpha and gamma on the transcription of Herpes Simplex virus type-1 (HSV-1) immediate early (IE) genes has been studied. Human amniotic cells (WISH) were transfected with a chimaeric plasmid containing the regulatory region of the HSV-1 IE genes controlling the expression of a reporter gene (CAT). Subsequently cells were infected with live HSV-1 to trans-activate the IE sequences. When cell samples were treated with IFN alpha or IFN gamma prior to viral infection, transcription of the CAT gene was greatly inhibited.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

De Stasio PR,Taylor MW

doi

10.1016/0006-291x(89)90011-9

subject

Has Abstract

pub_date

1989-03-15 00:00:00

pages

439-44

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)90011-9

journal_volume

159

pub_type

杂志文章

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