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A putative mesenchymal stem cells population isolated from adult human testes.

Abstract：

:Mesenchymal stem cells (MSCs) isolated from several adult human tissues are reported to be a promising tool for regenerative medicine. In order to broaden the array of tools for therapeutic application, we isolated a new population of cells from adult human testis termed gonadal stem cells (GSCs). GSCs express CD105, CD166, CD73, CD90, STRO-1 and lack hematopoietic markers CD34, CD45, and HLA-DR which are characteristic identifiers of MSCs. In addition, GSCs express pluripotent markers Oct4, Nanog, and SSEA-4. GSCs propagated for at least 64 population doublings and exhibited clonogenic capability. GSCs have a broad plasticity and the potential to differentiate into adipogenic, osteogenic, and chondrogenic cells. These studies demonstrate that GSCs are easily obtainable stem cells, have growth kinetics and marker expression similar to MSCs, and differentiate into mesodermal lineage cells. Therefore, GSCs may be a valuable tool for therapeutic applications.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Gonzalez R,Griparic L,Vargas V,Burgee K,Santacruz P,Anderson R,Schiewe M,Silva F,Patel A

doi

10.1016/j.bbrc.2009.05.103

subject

Has Abstract

pub_date

2009-08-07 00:00:00

pages

570-5

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01060-2

journal_volume

385

pub_type

杂志文章

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