当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > ICOS promotes group 2 innate lymphoid cell activation in lungs.

ICOS promotes group 2 innate lymphoid cell activation in lungs.

Abstract：

:Group 2 innate lymphoid cells (ILC2s) are newly identified, potent producers of type 2 cytokines, such as IL-5 and IL-13, and contribute to the development of allergic lung inflammation induced by cysteine proteases. Although it has been shown that inducible costimulator (ICOS), a costimulatory molecule, is expressed on ILC2s, the role of ICOS in ILC2 responses is largely unknown. In the present study, we investigated whether the interaction of ICOS with its ligand B7-related protein-1 (B7RP-1) can promote ILC2 activation. Cytokine production in ILC2s purified from mouse lungs was significantly increased by coculture with B7RP-1-transfected cells, and increased cytokine production was inhibited by monoclonal antibody-mediated blocking of the ICOS/B7RP-1 interaction. ILC2 expansion and eosinophil influx induced by papain, a cysteine protease antigen, in mouse lungs were significantly abrogated by blocking the ICOS/B7RP-1 interaction. Dendritic cells (DCs) in the lungs expressed B7RP-1 and the number of DCs markedly increased with papain administration. B7RP-1 expression on lung DCs was reduced after papain administration. This downregulation of B7RP-1 expression may be an indication of ICOS/B7RP-1 binding. These results indicate that ILC2s might interact with B7RP-1-expressing DCs in allergic inflammatory lung, and ICOS signaling can positively regulate the protease allergen-induced ILC2 activation followed by eosinophil infiltration into the lungs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kamachi F,Isshiki T,Harada N,Akiba H,Miyake S

doi

10.1016/j.bbrc.2015.06.005

subject

Has Abstract

pub_date

2015-08-07 00:00:00

pages

739-45

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)30058-9

journal_volume

463

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Demonstration of the phosphorylation-dependent interaction of tryptophan hydroxylase with the 14-3-3 protein.

    abstract：:The molecular mechanism of the phosphorylation-dependent activation of tryptophan hydroxylase is studied with respect to the role of the 14-3-3 protein. Reexamination of the system reconstituted with the purified TRH and the 14-3-3 protein showed that the level of the TRH activity correlated with the extent of the Ca2...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1796

    authors： Furukawa Y,Ikuta N,Omata S,Yamauchi T,Isobe T,Ichimura T

    更新日期：1993-07-15 00:00:00

  • MicroRNA-26a overexpression protects RGC-5 cells against H2O2-induced apoptosis.

    abstract：BACKGROUND:We intended to examine the functional role of microRNA 26 (miR-26a) in regulating H2O2-induced cytotoxicity and apoptosis in RGC-5 cells in vitro. METHOD:Various concentrations of H2O2 (0-1000 μM) were added in RGC-5 culture. Cell cytotoxicity was monitored by viability assay and gene expression level of mi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.02.164

    authors： Kang Y,Jia P,Zhao H,Hu C,Yang X

    更新日期：2015-05-01 00:00:00

  • Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration.

    abstract：:Cell migration is a critical process during development, tissue repair, and cancer metastasis. It requires complex processes of cell adhesion, cytoskeletal dynamics, and force generation. Lis1 plays an important role in the migration of neurons, fibroblasts and other cell types, and is essential for normal development...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.02.151

    authors： Jheng GW,Hur SS,Chang CM,Wu CC,Cheng JS,Lee HH,Chung BC,Wang YK,Lin KH,Del Álamo JC,Chien S,Tsai JW

    更新日期：2018-03-11 00:00:00

  • Thrombin induces rapid PAR1-mediated non-classical FGF1 release.

    abstract：:Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.09.107

    authors： Duarte M,Kolev V,Soldi R,Kirov A,Graziani I,Oliveira SM,Kacer D,Friesel R,Maciag T,Prudovsky I

    更新日期：2006-11-24 00:00:00

  • VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells.

    abstract：:There is increasing evidence for the presence of cancer stem cells (CSCs) in malignant brain tumors, and these CSCs may play a pivotal role in tumor initiation, growth, and recurrence. Vascular endothelial growth factor (VEGF) promotes the proliferation of vascular endothelial cells (VECs) and the neurogenesis of neur...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.06.094

    authors： Oka N,Soeda A,Inagaki A,Onodera M,Maruyama H,Hara A,Kunisada T,Mori H,Iwama T

    更新日期：2007-08-31 00:00:00

  • Aggregation of ALS-linked FUS mutant sequesters RNA binding proteins and impairs RNA granules formation.

    abstract：:Protein aggregate/inclusion is one of hallmarks for neurodegenerative disorders including amyotrophic lateral sclerosis (ALS). FUS/TLS, one of causative genes for familial ALS, encodes a multifunctional DNA/RNA binding protein predominantly localized in the nucleus. C-terminal mutations in FUS/TLS cause the retention ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.08.115

    authors： Takanashi K,Yamaguchi A

    更新日期：2014-09-26 00:00:00

  • Tumor necrosis factor (TNF) interferes with insulin signaling through the p55 TNF receptor death domain.

    abstract：:Tumor necrosis factor (TNF) contributes to insulin resistance by binding to the 55kDa TNF receptor (TNF-R55), resulting in serine phosphorylation of proteins such as insulin receptor (IR) substrate (IRS)-1, followed by reduced tyrosine phosphorylation of IRS-1 through the IR and, thereby, diminished IR signal transduc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.01.140

    authors： Csehi SB,Mathieu S,Seifert U,Lange A,Zweyer M,Wernig A,Adam D

    更新日期：2005-04-01 00:00:00

  • The endogenous agonist, β-alanine, activates glycine receptors in rat spinal dorsal neurons.

    abstract：:β-alanine is a structural analog of glycine and γ-aminobutyric acid (GABA) and is thought to be involved in the modulation of nociceptive information at the spinal cord. However, it is not known whether β-alanine exerts its effect in substantia gelatinosa (SG) neurons of the spinal dorsal horn, where glycine and GABA ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.04.183

    authors： Seino Y,Ohashi N,Kohno T

    更新日期：2018-06-12 00:00:00

  • Structure-activity relationship of endothelin: importance of charged groups.

    abstract：:Endothelin (ET)-related peptides including ET-1 (1-39) were synthesized, and their constricting activity in rat pulmonary artery rings and pressor activity in unanesthetized rat were measured to elucidate their structure-activity relationship. The vasoconstrictor activities of ET-2, ET-3 and sarafotoxin S6b were one-h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92153-0

    authors： Nakajima K,Kubo S,Kumagaye S,Nishio H,Tsunemi M,Inui T,Kuroda H,Chino N,Watanabe TX,Kimura T

    更新日期：1989-08-30 00:00:00

  • Lyso(bis)phosphatidic acid: a novel source of arachidonic acid for oxidative metabolism by rabbit alveolar macrophages.

    abstract：:To identify the source of arachidonic acid utilized for eicosanoid production, rabbit alveolar macrophages were challenged with 1.0 microM 12-O-tetradecanoylphorbol-13-acetate (TPA) or 3.8 microM Ca+2 ionophore A23187 for 3 h. Upon stimulation with TPA, a loss of [3H]arachidonic acid from phosphatidylcholine, phosphat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90487-5

    authors： Cochran FR,Connor JR,Roddick VL,Waite BM

    更新日期：1985-07-31 00:00:00

  • Two domains of the epidermal growth factor receptor are involved in cytoskeletal interactions.

    abstract：:Epidermal growth factor receptor can interact directly with F-actin through an actin-binding domain. In the present study, a mutant EGFR, lacking a previously identified actin-binding domain (ABD 1), was still able to bind elements of the cytoskeleton. A second EGFR actin-binding domain (ABD 2) was identified in the r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.138

    authors： Song W,Wu J,Ge G,Lin Q

    更新日期：2008-06-13 00:00:00

  • Immunoreactive helodermin-like peptides in rat: a new class of mammalian neuropeptides related to secretin and VIP.

    abstract：:Helodermin is a peptide from the venom of the lizard Heloderma suspectum (Gila Monster) showing a high degree of sequence similarity with VIP, PHI and secretin in its N-terminal moiety. The present data support the presence of peptide(s) closely related to helodermin in the brain, gut and salivary glands of rat. In ou...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90422-x

    authors： Robberecht P,De Graef J,Woussen MC,Vandermeers-Piret MC,Vandermeers A,De Neef P,Cauvin A,Yanaihara C,Yanaihara N,Christophe J

    更新日期：1985-07-16 00:00:00

  • Deficient repair of 8-hydroxyguanine in the BxPC-3 pancreatic cancer cell line.

    abstract：:Elevated levels of oxidatively induced DNA lesions have been reported in malignant pancreatic tissues relative to normal pancreatic tissues. However, the ability of the pancreatic cancer cells to remove these lesions has not previously been addressed. This study analyzed the effectiveness of the pancreatic cancer cell...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.08.134

    authors： Nyaga SG,Lohani A,Evans MK

    更新日期：2008-11-14 00:00:00

  • Peptide growth factors markedly decrease the ligand binding of angiotensin II type 2 receptor in rat cultured vascular smooth muscle cells.

    abstract：:Of two major isoforms of angiotensin II receptors, AT1 and AT2, biological roles of AT2 remain unclear. Using vascular smooth muscle cells, we investigated the regulation of expression of AT2 by growth factors in comparison with that of AT1. The cultured rat aorta smooth muscle cells had detectable AT2 binding sites, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1844

    authors： Kambayashi Y,Bardhan S,Inagami T

    更新日期：1993-07-15 00:00:00

  • Pharmacological characterization of a selective agonist for bombesin receptor subtype-3.

    abstract：:Bombesin receptor subtype-3 (BRS-3) is an orphan G protein-coupled receptor in the bombesin receptor family that still awaits identification of its natural ligand. BRS-3 deficient mice develop a mild late-onset obesity with metabolic defects, implicating BRS-3 plays a role in feeding and metabolism. We describe here t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.07.006

    authors： Zhang L,Nothacker HP,Wang Z,Bohn LM,Civelli O

    更新日期：2009-09-18 00:00:00

  • Properties of a thermoactive beta-1,3-1,4-glucanase (lichenase) from Clostridium thermocellum expressed in Escherichia coli.

    abstract：:A Clostridium thermocellum gene (licB) encoding a thermoactive 1,3-1,4-beta-glucanase (lichenase) with a molecular weight of about 35,000 was localized on a 1.5-kb DNA fragment by cloning and expression in E. coli. The enzyme acts on beta-glucans with alternating beta-1,3- and beta-1,4-linkages such as barley beta-glu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)92004-4

    authors： Schimming S,Schwarz WH,Staudenbauer WL

    更新日期：1991-05-31 00:00:00

  • Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity.

    abstract：:Mitochondrial pyruvate carrier (MPC), composed of MPC1 and MPC2, can modulate pyruvate oxidation in mitochondrial and MPC1 expression correlates with poor prognosis of multiple cancers. Here, we reported that MPC1 is acetylated and its main acetylation sites are: K45 and K46. Sirt3 binds to and deacetylates MPC1. High...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.11.036

    authors： Liang L,Li Q,Huang L,Li D,Li X

    更新日期：2015-12-25 00:00:00

  • Involvement of endogenous neuromedin U and neuromedin S in thermoregulation.

    abstract：:We investigated the possible involvement of neuromedin U (NMU) and neuromedin S (NMS) in thermoregulation in rats. Intracerebroventricular (icv) injection of NMU or NMS increased the back surface temperature (BS-T) in a dose-dependent manner during both the light and dark periods. Pre-treatment with the β3 blocker SR5...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.01.155

    authors： Nakahara K,Akagi A,Shimizu S,Tateno S,Qattali AW,Mori K,Miyazato M,Kangawa K,Murakami N

    更新日期：2016-02-19 00:00:00

  • Detection and analysis of the human D4 dopamine receptor gene (DRD4) sequence variant in the Japanese and Mongolian population.

    abstract：:A PCR-based Sma I restriction fragment length polymorphism (RFLP) in the human D4 dopamine receptor (DRD4) gene was investigated in 200 subjects each of Japanese and Mongolian populations. When compared to allele frequencies for Caucasians previously reported by Petronis et al., Japanese and Mongolian populations show...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0479

    authors： Nakatome M,Honda K,Tun Z,Wakasugi C

    更新日期：1996-03-27 00:00:00

  • Urocortin: a beneficial or detrimental agent to endothelium?

    abstract：:As a member of the corticotropin-releasing factor (CRF) family, urocortin (UCN) has been demonstrated to show diverse effects on cardiovascular system. It is commonly considered as a protective agent on vascular function. However, a growing body of evidence suggests that some effects of UCN may lead to endothelial dys...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2008.01.157

    authors： Yang C,Xu Y,Li S

    更新日期：2008-07-04 00:00:00

  • Transcriptional regulation of mouse MARCKS promoter in immortalized hippocampal cells.

    abstract：:Mouse MARCKS is a prominent myristoylated alanine-rich C kinase substrate implicated in brain development, calcium/calmodulin signaling, and membrane cytoskeletal restructuring, and is developmentally regulated in a cell- and tissue-specific fashion. In this study, transcriptional regulation of mouse MARCKS promoter i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6655

    authors： Wang L,Liu X,Lenox RH

    更新日期：2002-04-12 00:00:00

  • Classification of ADAMTS binding sites: The first step toward selective ADAMTS7 inhibitors.

    abstract：:Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease. In carotid arteries of rats, neointima formation after balloon-mediated injury goes along with enhanced Adamts7 expression. Vice versa, Adamts7-deficient mice display reduced neointima formation following vascular injury. A...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.02.025

    authors： Müller M,Kessler T,Schunkert H,Erdmann J,Tennstedt S

    更新日期：2016-03-11 00:00:00

  • IL-33 signaling fuels outgrowth and metastasis of human lung cancer.

    abstract：:IL-33 is a member of IL-1 superfamily that drives production of Th2-related cytokines. Recently, accumulating evidence suggest an involvement of IL-33 in carcinogenesis. Herein, we determine a close correlation of IL-33 expression and cancer progress in patients with non-small-cell lung cancer (NSCLC). Overexpression ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.09.081

    authors： Wang C,Chen Z,Bu X,Han Y,Shan S,Ren T,Song W

    更新日期：2016-10-21 00:00:00

  • Nitric oxide contributes to tissue injury in mercuric chloride-induced autoimmunity.

    abstract：:Recent data has suggested a role for nitric oxide (NO) both in the induction of immunity and as an effector of tissue injury in experimental models of inflammation. In this study, we have tested the efficacy of two inhibitors of NO synthase, NG-monomethyl-L-arginine (L-NMMA) and aminoguanidine (AG), to modify the auto...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2806

    authors： Woolfson RG,Qasim FJ,Thiru S,Oliveira DB,Neild GH,Mathieson PW

    更新日期：1995-12-14 00:00:00

  • Isozyme analysis of human normal polymorphonuclear leukocyte phosphofructokinase.

    abstract：:Phosphofructokinase (PFK) from human polymorphonuclear leukocytes (PMN) was characterized by immunological titration with subunit specific antibodies, column chromatography on QAE-Sephadex and SDS-polyacrylamide gel electrophoresis. Two different isozymes, M-type and L-type, were found. The M(r) values of the M and L ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2706

    authors： Durante P,Raleigh X,Gómez ME,Campos G,Ryder E

    更新日期：1995-11-22 00:00:00

  • Computer studies on the stereostructure and quantum chemical properties of 6-pyruvoyl tetrahydropterin, the key intermediate of tetrahydrobiopterin biosynthesis.

    abstract：:The optimized geometry of the conformation of atoms constituting the 6-pyruvoyl tetrahydropterin molecule, the labile key intermediate of tetrahydrobiopterin biosynthesis, was obtained by molecular orbital calculations within the MINDO/3 framework. The stereostructure of the molecule showing the preferred mode for bin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90888-e

    authors： Katoh S,Sueoka T,Kurihara T

    更新日期：1991-04-15 00:00:00

  • Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD.

    abstract：:trans-Resveratrol (3,4',5-trihydroxystilbene; RES), a polyphenol found in particularly high concentrations in red wine, has recently attracted intense interest for its potentially beneficial effects on human health. Here, we report the effects of long-term exposure to micromolar concentrations of RES on antioxidant an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.12.138

    authors： Robb EL,Page MM,Wiens BE,Stuart JA

    更新日期：2008-03-07 00:00:00

  • Novel motifs in amino acid permease genes from Leishmania.

    abstract：:Eight amino acid permease genes from the protozoan parasite Leishmania donovani (AAPLDs) were cloned, sequenced, and shown to be expressed in promastigotes. Seven of these belong to the amino acid transporter-1 and one to the amino acid polyamino-choline superfamilies. Using these sequences as well as known and charac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.09.212

    authors： Akerman M,Shaked-Mishan P,Mazareb S,Volpin H,Zilberstein D

    更新日期：2004-12-03 00:00:00

  • Lack of CaV3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor.

    abstract：:T-type Ca(2+) channels have been implicated in tremorogenesis and motor coordination. The α1 subunit of the Ca(V)3.1 T-type Ca(2+) channel is highly expressed in motor pathways in the brain, but knockout of the Ca(V)3.1 gene (α(1G)(-/-)) per se causes no motor defects in mice. Thus, the role of Ca(V)3.1 channels in mo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.082

    authors： Chang KY,Park YG,Park HY,Homanics GE,Kim J,Kim D

    更新日期：2011-06-24 00:00:00

  • A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm.

    abstract：:Injection of DN-BR mRNA encoding a dominant negative type I receptor for bone morphogenetic protein 4 (BMP4) converted prospective ectoderm into neural tissue in Xenopus animal cap explants, in the absence of expression of mesodermal marker genes. The injected caps expressed a general neural marker NCAM and the forebr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1958

    authors： Xu RH,Kim J,Taira M,Zhan S,Sredni D,Kung HF

    更新日期：1995-07-06 00:00:00