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The endogenous agonist, β-alanine, activates glycine receptors in rat spinal dorsal neurons.

Abstract：

:β-alanine is a structural analog of glycine and γ-aminobutyric acid (GABA) and is thought to be involved in the modulation of nociceptive information at the spinal cord. However, it is not known whether β-alanine exerts its effect in substantia gelatinosa (SG) neurons of the spinal dorsal horn, where glycine and GABA play an important role in regulating nociceptive transmission from the periphery. Here, we investigated the effects of β-alanine on inhibitory synaptic transmission in adult rat SG neurons using whole-cell patch-clamp. β-alanine dose-dependently induced outward currents in SG neurons. Current-voltage plots revealed a reversal potential at approximately -70 mV, which was close to the equilibrium potential of Cl-. Pharmacological analysis revealed that β-alanine activates glycine receptors, but not GABAA receptors. These results suggest that β-alanine hyperpolarizes the membrane potential of SG neurons by activating Cl- channels through glycine receptors. Our findings raise the possibility that β-alanine may modulate pain sensation through glycine receptors.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Seino Y,Ohashi N,Kohno T

doi

10.1016/j.bbrc.2018.04.183

subject

Has Abstract

pub_date

2018-06-12 00:00:00

pages

897-901

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)30976-8

journal_volume

500

pub_type

杂志文章

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