Hepatocyte growth factor accelerates the wound repair of cultured gastric mucosal cells.

Abstract:

:Effects of hepatocyte growth factor (HGF) on gastric wound repair were assessed. Artificial wounds of uniform size were made by mechanical cell denudation in confluent rabbit gastric mucosal cell sheets. The changes in wound size were analyzed quantitatively. The wound repair process contained an initial migration stage and a later proliferation stage. The wound was completely repaired in 36 h in controls; this repair was accelerated by HGF with the induction of cell migration followed by proliferation and was retarded by tyrosine protein kinase inhibitor genistein. HGF might play some roles in gastric ulcer healing.

authors

Watanabe S,Hirose M,Wang XE,Maehiro K,Murai T,Kobayashi O,Nagahara A,Sato N

doi

10.1006/bbrc.1994.1394

subject

Has Abstract

pub_date

1994-03-30 00:00:00

pages

1453-60

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)71394-5

journal_volume

199

pub_type

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