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Effects of D- and L-thyroxine on the glucocorticoid binding capacity of adult rat liver.

Abstract：

:Administration of either D- or L-thyroxine (T4) significantly increased the glucocorticoid binding capacity of cytosol of the livers of adrenalectomized adult rats. Administration of up to 0.5 mg/100 g body wt. of L-T4 was more effective than that of D-T4, but higher doses (0.8-3 mg/100 g body wt.) of D-T4 increased the binding capacity markedly to more than that with L-T4. T4- administration did not alter the apparent dissociation constant of glucocorticoid binding proteins for glucocorticoid binding, or their behavior on DEAE-cellulose chromatography either before or after thermal activation (23 degrees C for 40 min). Thus the increased binding capacity seemed to be due to increase in the level of glucocorticoid receptor in rat liver.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Naito K,Isohashi F,Tsukanaka K,Horiuchi M,Okamoto K,Matsunaga T,Sakamoto Y

doi

10.1016/0006-291x(85)90171-8

subject

Has Abstract

pub_date

1985-06-14 00:00:00

pages

447-52

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)90171-8

journal_volume

129

pub_type

杂志文章

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