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HGF-induced capillary morphogenesis of endothelial cells is regulated by Src.

Abstract：

:The signal transduction pathway involved in hepatocyte growth factor (HGF)-induced capillary morphogenesis of endothelial cells was investigated. HGF-induced capillary morphogenesis of the murine spleen endothelial cell line MSS31 was inhibited by a Src family kinase inhibitor, PP2. Stable expression of kinase-inactive Src in MSS31 cells inhibited HGF-induced activation of Src as well as capillary morphogenesis. The HGF-induced capillary morphogenesis of human umbilical vein endothelial cells was also inhibited by PP2 and was reduced by the downregulation of Src by small interfering RNA. These results suggest that HGF induces capillary morphogenesis of endothelial cells through Src.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kanda S,Kanetake H,Miyata Y

doi

10.1016/j.bbrc.2006.03.183

subject

Has Abstract

pub_date

2006-06-02 00:00:00

pages

617-22

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00744-3

journal_volume

344

pub_type

杂志文章

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