Enzymatic and thermodynamic profiles of a heterotetramer lactate dehydrogenase isozyme in swine.

abstract：:The cyclin-dependent kinase (CDK) inhibitor p27(Kip1) is an important regulator of cell cycle progression as it negatively regulates G(0/1) progression and plays a major role in controlling the cell cycle. The screening of the p27(Kip1) sequence identified many potential phosphorylation sites. Although Ser(10) and Thr...

journal_title：Biochemical and biophysical research communications

authors： Guan X,Chen L,Wang J,Geng H,Chu X,Zhang Q,Du L,De W

更新日期：2006-09-01 00:00:00

abstract：:Cultivated rice (Oryza sativa) possesses various labdane-related diterpene synthase genes, homologs of ent-copalyl diphosphate synthase (CPS) and ent-kaurene synthase (KS) that are responsible for the biosynthesis of phytohormone gibberellins. The CPS homologs and KS like (KSL) homologs successively converted geranylg...

journal_title：Biochemical and biophysical research communications

authors： Toyomasu T,Miyamoto K,Shenton MR,Sakai A,Sugawara C,Horie K,Kawaide H,Hasegawa M,Chuba M,Mitsuhashi W,Yamane H,Kurata N,Okada K

更新日期：2016-11-18 00:00:00

abstract：:We compared the nitric oxide (NO)-generating behavior of nitroglycerin (NTG), pentaerythritol trinitrate (PEtriN) and isosorbide dinitrate (ISDN), in the microsomal preparation of bovine coronary artery smooth muscle cells. The comparative NO generating activities among these nitrates were consistent with their relati...

journal_title：Biochemical and biophysical research communications

authors： Chung SJ,Fung HL

更新日期：1992-06-30 00:00:00

abstract：:Kinetics measurements of the electron transfer between ferricytochrome c and liposomal ferrocytochrome c1 (with and without the hinge protein) were performed. The observed rate constants(kobs) of electron transfer between liposomal ferrocytochrome c1 and ferricytochrome c at different ionic strengths were measured in ...

journal_title：Biochemical and biophysical research communications

authors： Kim CH,King TE,Balny C

更新日期：1989-08-30 00:00:00

abstract：:Binding affinity and selectivity are critical properties of aptamers that must be optimized for any application. The sulforhodamine B binding RNA aptamer (SRB-2) is a somewhat promiscuous aptamer that can bind ligands that vary markedly in shape, size and charge. Here we categorize potential ligands based on their bin...

journal_title：Biochemical and biophysical research communications

authors： Piccolo KA,McNeil B,Crouse J,Lim SJ,Bickers SC,Hopkins WS,Dieckmann T

更新日期：2020-08-27 00:00:00

abstract：:Endocannabinoids including anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are important lipid mediators for immunosuppressive effects and for appropriate homeostasis via their G-protein-coupled cannabinoid (CB) receptors in mammalian organs and tissues, and may be involved in wound healing in some organs. The phys...

journal_title：Biochemical and biophysical research communications

authors： Kozono S,Matsuyama T,Biwasa KK,Kawahara K,Nakajima Y,Yoshimoto T,Yonamine Y,Kadomatsu H,Tancharoen S,Hashiguchi T,Noguchi K,Maruyama I

更新日期：2010-04-16 00:00:00

abstract：:An aminopeptidase secreted from Streptomyces septatus TH-2 (SSAP) was identified as a heat stable enzyme, and the Ssap gene was cloned and sequenced. The primary structure of SSAP showed 71% identity with that of a Streptomyces griseus aminopeptidase (SGAP), however, it lacked a unique calcium binding site. The recomb...

journal_title：Biochemical and biophysical research communications

authors： Arima J,Iwabuchi M,Hatanaka T

更新日期：2004-04-30 00:00:00

abstract：:Cisplatin plays a key role in treating small cell lung cancer (SCLC); however, the rapid development of cisplatin resistance limits its treatment effect. The detailed mechanisms of cisplatin-resistance, particularly in SCLC, remain unclear. We analyzed the differentially expressed genes (DEGs) between cisplatin-resist...

journal_title：Biochemical and biophysical research communications

authors： Ma K,Li S,Huo X,Guo M,Du X,Li C,Liu X,Lv J,Chen Z

更新日期：2020-12-10 00:00:00

abstract：:The 65 kDa C8-binding protein or homologous restriction factor (C8bp/HRF) protects cells from complement (C)-mediated lysis by binding to C8 and abrogating lytic channel formation. Human C8bp/HRF is shown here to be immunologically related to human C8 and C9 and to murine lymphocyte poreforming protein (PFP, perforin)...

journal_title：Biochemical and biophysical research communications

authors： Young JD,Rosse WF,Hasselkus-Light CS

更新日期：1990-01-30 00:00:00

abstract：:We have previously shown that murine solid tumor cells express high affinity IL-4 receptors (IL-4R) which are internalized after binding to ligand. In the present study, we have examined the regulation of IL-4R by TNF. We demonstrate that TNF upregulated the expression of IL-4R on murine MCA-106 sarcoma cells. Maximum...

journal_title：Biochemical and biophysical research communications

authors： Puri RK,Leland P

更新日期：1993-12-30 00:00:00

abstract：:cDNAs were molecularly cloned for proteins specifically expressed in embryo as well as in a chemically induced rat pancreatic B cell tumor in which virally related oncogenes such as v-myc, v-src, v-yes, v-mos and v-kis were previously demonstrated not to be expressed. A plasmid cDNA library consisting of 48,000 indepe...

journal_title：Biochemical and biophysical research communications

authors： Soma G,Kitahara N,Andoh T

更新日期：1984-10-15 00:00:00

abstract：:The aromatic l-alpha-hydroxy acid dehydrogenase (AHDAH) from Trypanosoma cruzi has over 50% sequence identity with cytosolic malate dehydrogenases (cMDHs), yet it is unable to reduce oxaloacetate. Molecular modeling of the three-dimensional structure of AHADH using the pig cMDH as template directed the construction of...

journal_title：Biochemical and biophysical research communications

authors： Vernal J,Fiser A,Sali A,Müller M,Cazzulo JJ,Nowicki C

更新日期：2002-04-26 00:00:00

abstract：:Previous studies have demonstrated expression of Toll-like receptors (TLRs) in the surface epithelium of normal ovaries (OSE) and in epithelial ovarian tumors. Most notably, OSE-derived cancers express TLR4, which activates the nuclear factor-kappa B (NF-κB) signaling cascade as a mediator of inflammatory response. Cu...

journal_title：Biochemical and biophysical research communications

authors： Woods DC,White YA,Dau C,Johnson AL

更新日期：2011-06-17 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae, Ca(2+) signaling mediated by the Ca(2+)/calmodulin dependent phosphatase, calcineurin, is required for survival during environmental stress. One role of the phosphatase under these conditions is to activate gene expression through its regulation of the Crz1p ("crazy") transcripti...

journal_title：Biochemical and biophysical research communications

authors： Cyert MS

更新日期：2003-11-28 00:00:00

abstract：:The role of mycothiol in mycobacteria was examined by comparative analysis of mutants disrupted in the four known genes encoding the protein machinery needed for mycothiol biosynthesis. These mutants were sensitive to acid stress, antibiotic stress, alkylating stress, and oxidative stress indicating that mycothiol and...

journal_title：Biochemical and biophysical research communications

authors： Rawat M,Johnson C,Cadiz V,Av-Gay Y

更新日期：2007-11-09 00:00:00

abstract：:Adenovirus DNA synthesis carried out in vitro was inhibited by the aphidicolin. However, 30% of the DNA synthesis was resistant to aphidicolin even at a concentration of 200 micrograms/ml. When the distribution patterns of the radioactivity of the products synthesized in the presence of 50 micrograms/ml of the drug wa...

journal_title：Biochemical and biophysical research communications

authors： Ariga H

更新日期：1983-05-31 00:00:00

abstract：:HMG-CoA reductase was located to the envelope membranes of pea etioplasts, the first report of the suborganelle localization of this key enzyme in isoprenoid synthesis. The enzyme was purified 156 fold from isolated envelope membranes. Purification was achieved by detergent solubilization, hydroxylapatite chromatograp...

journal_title：Biochemical and biophysical research communications

authors： Wilson TM,Russell DW

更新日期：1992-04-15 00:00:00

abstract：:Hartnup disorder is an autosomal recessive phenotype involving a transporter for monoamino-monocarboxylic acids. Genetic analysis of the mouse model mapped its locus to human chromosome 11q13 (8). We report here the results of linkage analysis in two Japanese first cousin-marriage families. In the first family, the pr...

journal_title：Biochemical and biophysical research communications

authors： Nozaki J,Dakeishi M,Ohura T,Inoue K,Manabe M,Wada Y,Koizumi A

更新日期：2001-06-08 00:00:00

abstract：:Aberrant expression of cell cycle regulators have been implicated in prostate cancer development and progression. Therefore, understanding transcriptional networks controlling the cell cycle remain a challenge in the development of prostate cancer treatment. In this study, we found that icilin, a super-cooling agent, ...

journal_title：Biochemical and biophysical research communications

authors： Lee S,Chun JN,Kim SH,So I,Jeon JH

更新日期：2013-11-29 00:00:00

abstract：:The binding of leptin to hypothalamic neurons elicits inhibition of orexigenic NPY/AgRP neurons and stimulation of anorexigenic POMC/CART neurons. Projections of serotonergic neurons onto POMC neurons suggest that leptin and serotonin converge onto POMC neurons to regulate body weight. We probed the interaction of the...

journal_title：Biochemical and biophysical research communications

authors： Wang B,Chehab FF

更新日期：2006-12-15 00:00:00

abstract：:Store-operated Ca(2+) entry (SOCE) is crucial for various physiological responses in immune cells. Although it is known that STIM1 relocates into discrete puncta juxtaposed to the plasma membrane to initiate SOCE, the machinery modulating the function of STIM1 remains unclear. We explored to find its modulators using ...

journal_title：Biochemical and biophysical research communications

authors： Fujii Y,Shiota M,Ohkawa Y,Baba A,Wanibuchi H,Kinashi T,Kurosaki T,Baba Y

更新日期：2012-06-15 00:00:00

abstract：:Each chromosome occupies its own-specific space called a 'territory' within the interphase nucleus, and the arrangement of chromosome territories (CTs) is important in epigenetic mechanisms. The molecular mechanism to determine the positioning of CTs, however, remains unknown. On the other hand, dioxin is known to be ...

journal_title：Biochemical and biophysical research communications

authors： Oikawa K,Yoshida K,Takanashi M,Tanabe H,Kiyuna T,Ogura M,Saito A,Umezawa A,Kuroda M

更新日期：2008-09-19 00:00:00

abstract：:Previously, we reported the identification and characterization of a novel cancer/testis antigen gene, CAGE(4), that was expressed in various histological types of tumors, but not in normal tissues, with the exception of the testis. To date, molecular mechanisms for the expression of CAGE have never been studied. In o...

journal_title：Biochemical and biophysical research communications

authors： Cho B,Lee H,Jeong S,Bang YJ,Lee HJ,Hwang KS,Kim HY,Lee YS,Kang GH,Jeoung DI

更新日期：2003-07-18 00:00:00

abstract：:Bovine myocardial sarcolemma and sarcoplasmic reticulum vesicle preparations contained calcium-dependent protease inhibitor protein. No inhibitor was detected in mitochondrial membranes. The membrane-bound inhibitor co-purified with the marker enzymes for sarcolemma and sarcoplasmic reticulum, Na+,K+-ATPase and Ca2+,K...

journal_title：Biochemical and biophysical research communications

authors： Mellgren RL,Lane RD,Kakar SS

更新日期：1987-02-13 00:00:00

abstract：:Sugarcane (Saccharum sp. hybrid) provides the main source of sugar for humans. Sugarcane mosaic disease (SMD) is a major threat to sugarcane production. Currently, control of SMD is mainly dependent on breeding resistant cultivars through hybridization, which is time-consuming. Understanding the mechanism of viral inf...

journal_title：Biochemical and biophysical research communications

authors： Zhai Y,Deng Y,Cheng G,Peng L,Zheng Y,Yang Y,Xu J

更新日期：2015-10-23 00:00:00

abstract：:Glucocorticoids inhibit prostaglandin biosynthesis by inducing the formation of lipocortins. In human amnion cells dexamethasone elicited a concentration-dependent increase in prostaglandin production and raised intracellular lipocortin 1 concentrations. Dexamethasone could also potentiate the epidermal growth factor ...

journal_title：Biochemical and biophysical research communications

authors： Mitchell MD,Lytton FD,Varticovski L

更新日期：1988-02-29 00:00:00

abstract：:p21(Waf1/Cip1) is one of the key regulatory proteins in cell cycle, terminal differentiation, and apoptosis. Its promoter was shown to be transactivated by the wild-type p53 protein as well as in a p53-independent manner. In this report, we demonstrate that E1AF, an ets-related transcription factor, activates the huma...

journal_title：Biochemical and biophysical research communications

authors： Funaoka K,Shindoh M,Yoshida K,Hanzawa M,Hida K,Nishikata S,Totsuka Y,Fujinaga K

更新日期：1997-07-09 00:00:00

abstract：:Fibroblast growth factor (FGF)-23 was identified as a causative factor of tumor-induced osteomalacia and also as a responsible gene for autosomal dominant hypophosphatemic rickets. To clarify the pathophysiological roles of FGF-23 in these diseases, we generated its transgenic mice. The transgenic mice expressing huma...

journal_title：Biochemical and biophysical research communications

authors： Shimada T,Urakawa I,Yamazaki Y,Hasegawa H,Hino R,Yoneya T,Takeuchi Y,Fujita T,Fukumoto S,Yamashita T

更新日期：2004-02-06 00:00:00

abstract：:BET inhibitors (BETi) exert an excellent anti-cancer activity in breast cancer. However, the identification of new potential targets to enhance breast cancer sensitivity to BETi is still an enormous challenge. Both NR5A2 and NCOA3 are frequently involved in cancer cells resistance to chemotherapy, also associated with...

journal_title：Biochemical and biophysical research communications

authors： Qiao J,Chen Y,Mi Y,Jin H,Huang T,Liu L,Gong L,Wang L,Wang Q,Zou Z

更新日期：2020-09-17 00:00:00

abstract：:The bacterial toxin Shiga toxin (Stx) is transported retrogradely from early endosomes to the Golgi apparatus on its way to the endoplasmic reticulum (ER) and the cytosol. In this study we explored the functions of the two phosphoinositide binding proteins Sorting nexin 1 (SNX1) and Sorting nexin 2 (SNX2) in endosomal...

journal_title：Biochemical and biophysical research communications

authors： Utskarpen A,Slagsvold HH,Dyve AB,Skånland SS,Sandvig K

更新日期：2007-06-29 00:00:00