Regional distribution of metorphamide in rat and guinea pig brain.

abstract：:Locally applied radiation to the tumor is reported to stimulate systemic immune response. During radiotherapy to the abdominal cancer, spleen often receives certain dose, though as an important immune organ, little is known about the impact of splenic irradiation (SI) on systemic immune and local tumor control. Throug...

journal_title：Biochemical and biophysical research communications

authors： Chen HY,Xie HY,Liu XX,Li LF,Bai YR,Gao JX

更新日期：2019-02-26 00:00:00

abstract：:VEGF family members play important roles in angiogenesis and vascular permeability. VEGF-A-transgenic mice showed an increased vascularization with edema due to hyper-vascular permeability and subcutaneous hemorrhage as side effects. VEGF-A binds and activates two receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). To...

journal_title：Biochemical and biophysical research communications

authors： Kiba A,Sagara H,Hara T,Shibuya M

更新日期：2003-02-07 00:00:00

abstract：:Zta is a bZIP transcription factor (TF) in the Epstein-Barr virus that binds unmethylated and methylated DNA sequences. Substitution of cysteine 189 of Zta to serine (Zta(C189S)) results in a virus that is unable to execute the lytic cycle, which was attributed to a change in binding to methylated DNA sequences. To le...

journal_title：Biochemical and biophysical research communications

authors： Ray S,Tillo D,Assad N,Ufot A,Deppmann C,Durell SR,Porollo A,Vinson C

更新日期：2018-07-02 00:00:00

abstract：:Uracil-DNA glycosylase (UNG) is the primary enzyme responsible for removing uracil residues from DNA. Increasing evidence suggests that UNG may be a potential target for the development of novel antiviral and/or anticancer agents. To determine whether the uracil-DNA glycosylase inhibitor protein (UGI) could be used to...

journal_title：Biochemical and biophysical research communications

authors： Studebaker AW,Ariza ME,Williams MV

更新日期：2005-08-26 00:00:00

abstract：:We investigated the possible involvement of neuromedin U (NMU) and neuromedin S (NMS) in thermoregulation in rats. Intracerebroventricular (icv) injection of NMU or NMS increased the back surface temperature (BS-T) in a dose-dependent manner during both the light and dark periods. Pre-treatment with the β3 blocker SR5...

journal_title：Biochemical and biophysical research communications

authors： Nakahara K,Akagi A,Shimizu S,Tateno S,Qattali AW,Mori K,Miyazato M,Kangawa K,Murakami N

更新日期：2016-02-19 00:00:00

abstract：:Several recent studies have suggested that cancer stem cells (CSCs) are involved in resistance to gefitinib in non-small cell lung cancer (NSCLC). Oct4, a member of the POU-domain transcription factor family, has been shown to be involved in CSC properties of various cancers. We previously reported that Oct4 and the p...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi I,Takahashi F,Nurwidya F,Nara T,Hashimoto M,Murakami A,Yagishita S,Tajima K,Hidayat M,Shimada N,Suina K,Yoshioka Y,Sasaki S,Moriyama M,Moriyama H,Takahashi K

更新日期：2016-04-22 00:00:00

abstract：:Methiocarb, an aromatic-alkyl sulfide insecticide was enzymatically oxidized into its sulfoxide by microsomes from soybean cotyledons. No further oxidation into sulfone was detected. Distribution of the sulfoxidase activity was studied in soybean seedlings and found maximal in cotyledons. Subcellular fractionation of ...

journal_title：Biochemical and biophysical research communications

authors： Blee E,Durst F

更新日期：1986-03-28 00:00:00

abstract：:Triple-negative breast cancer (TNBC) that lacks expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) is a breast cancer subtype with very aggressive metastasis and poor prognosis. Unique cartilage matrix-associated protein (UCMA) is a vitamin K-dependent...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Lee YJ,Park SI,Kim JE

更新日期：2020-10-01 00:00:00

abstract：:Telmisartan, an angiotensin II type 1 receptor blocker (ARB), attenuates hyperglycemia-aggravated vascular inflammation by decreasing IκB kinase β (IKKβ) expression in endothelial cells. Because glycogen synthase 3β (GSK3β) is involved in inflammatory process by regulating nuclear factor-κB (NF-κB) activity, we invest...

journal_title：Biochemical and biophysical research communications

authors： Song KH,Bae SJ,Chang J,Park JH,Jo I,Cho KW,Cho DH

更新日期：2017-09-30 00:00:00

abstract：:Extracellular signal-regulated kinase 1 and 2 (ERK1/2) have been implicated as important regulators of metabolic homeostasis. Here we generated a new mouse model with genetic deletion of two ERK1/2 phosphatases, dual specificity phosphatase (DUSP) 6 and 8, to further define the role of ERK1/2 in obesity development. D...

journal_title：Biochemical and biophysical research communications

authors： Liu R,Peters M,Urban N,Knowlton J,Napierala T,Gabrysiak J

更新日期：2020-11-26 00:00:00

abstract：:We have created genital skin fibroblast cell lines directly from three patients in a Chinese family affected by androgen insensitivity syndrome (AIS). All patients in the family share an identical AR Arg840Cys mutant but show different disease phenotypes. By using the cell lines, we find that the mutation has not infl...

journal_title：Biochemical and biophysical research communications

authors： Wang M,Wang J,Zhang Z,Zhao Z,Zhang R,Hu X,Tan T,Luo S,Luo Z

更新日期：2005-09-23 00:00:00

abstract：:The subunit arrangement of wheat germ RNA polymerase II was examined using the cleavable cross-linking reagent dithiobis(succinimidyl propionate). Conditions were chosen such that the enzyme was active prior to treatment, and that most of the subunits were reactive towards the reagent. Our results indicate that the en...

journal_title：Biochemical and biophysical research communications

authors： Bateman E,Nicholson BH

更新日期：1984-06-15 00:00:00

abstract：:Epinephrine is known to be rapidly oxidized during sepsis. Ischemia and acidosis, which often accompany sepsis, are associated with the release of weakly bound cupric ions from plasma proteins. We investigated whether copper promotes oxidation of epinephrine at both physiological and acidic pH and whether D-Asp-D-Ala-...

journal_title：Biochemical and biophysical research communications

authors： Roberts A,Bar-Or D,Winkler JV,Rael LT

更新日期：2003-05-16 00:00:00

abstract：:The production of therapeutic monoclonal antibodies is costly; therefore, antigen-binding fragments (Fabs) can be used instead. However, their tendency toward aggregation can reduce the half-life in the plasma and the therapeutic effectiveness. To examine the effect of glycosylation on the properties of the Fab of a t...

journal_title：Biochemical and biophysical research communications

authors： Nakamura H,Oda-Ueda N,Ueda T,Ohkuri T

更新日期：2018-09-05 00:00:00

abstract：:The sarcoplasmic potassium concentration of a suspension of rat ventricular myocytes, prepared by collagenase-induced disruption of the myocardial mass, was determined by a null-point technique. Addition of digitonin resulted in a release of potassium from the cells which was interpreted as a flux from the sarcoplasm....

journal_title：Biochemical and biophysical research communications

authors： Fry CH,Ward JP,Twist VW,Powell T

更新日期：1986-05-29 00:00:00

abstract：:The enzymatic mechanism of a small ribosome-inactivating protein, gamma-momorcharin, purified from the seeds of Momordica charantia, has been characterized. By SDS-polyacrylamide and electrospray ionization mass spectrometry, its molecular weight was measured to be 11,500 daltons which is much lower than other RIPs kn...

journal_title：Biochemical and biophysical research communications

authors： Pu Z,Lu BY,Liu WY,Jin SW

更新日期：1996-12-04 00:00:00

abstract：:cDNAs encoding the long-chain acyl-CoA hydrolases (ACHs) from rat brain and liver, referred to as rBACH and rLACH1, respectively, were isolated and sequenced. The rBACH cDNA contained an open reading frame encoding a 338-amino acid polypeptide with a calculated molecular weight of 37,559, of which the deduced amino ac...

journal_title：Biochemical and biophysical research communications

authors： Yamada J,Furihata T,Iida N,Watanabe T,Hosokawa M,Satoh T,Someya A,Nagaoka I,Suga T

更新日期：1997-03-06 00:00:00

abstract：:A method for investigating the cellular response of polymorphonuclear leukocytes to various stimuli was introduced using simultaneously native (luminol-independent) and luminol dependent luminescence as an indicator for myeloperoxidase (MPO)-H2O2-halide and O2- mediated reactions. In experimental systems containing lo...

journal_title：Biochemical and biophysical research communications

authors： Roschger P,Graninger W,Klima H

更新日期：1984-09-28 00:00:00

abstract：:A novel neurotensin-like peptide, designated neuromedin N, has been isolated from porcine spinal cord by using a bioassay for a stimulant effect on guinea pig ileum. By microsequencing, the amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is found to be quite homologous to th...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Kangawa K,Matsuo H

更新日期：1984-07-31 00:00:00

abstract：:Fibronectin, von Willebrand factor, and fibrinogen each bind to the glycoprotein IIb-IIIa complex on activated platelets via an arg-gly-asp-ser (RGDS) sequence present within the adhesive proteins. Both the IIb and IIIa polypeptides of the IIb-IIIa complex on thrombin activated platelets are specifically and extensive...

journal_title：Biochemical and biophysical research communications

authors： Santoro SA,Lawing WJ Jr

更新日期：1989-04-14 00:00:00

abstract：:Large tonsillar lymphocytes labeled with [3H]thymidine reverted to small lymphocytes with concomitant loss of [3H]DNA upon culturing. The decrease of labeled DNA content and size of large lymphocytes was demonstrated by flow cytometry and cell sorting. These observations suggest that stimulated lymphocytes may revert ...

journal_title：Biochemical and biophysical research communications

authors： Sasvari-Szekely M,Staub M,Taljanidisz J,Szabo G Jr,Takacs J,Antoni F

更新日期：1984-12-28 00:00:00

abstract：:We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity. Binding of p53 to the kin...

journal_title：Biochemical and biophysical research communications

authors： Ababneh M,Götz C,Montenarh M

更新日期：2001-05-04 00:00:00

abstract：:The effects of a synthetic protein kinase C (PKC) activator, (-)-indolactam V (ILV), were studied in SH-SY5Y human neuroblastoma cells. (-)-ILV induced a translocation of PKC from cytosol to plasma membrane and displaced 3H-phorbol dibutyrate binding in the micromolar range. In addition, (-)-ILV caused a decreased sen...

journal_title：Biochemical and biophysical research communications

authors： Heikkilä J,Akerman KE

更新日期：1989-08-15 00:00:00

abstract：:A small fraction of tumor cells are thought to possess the potential for both multiple-lineage differentiation and self-renewal, which underlies the cancer stem cell hypothesis. However, the differentiation mechanisms of these cells have not been elucidated due to a lack of appropriate culture methods. Here, we establ...

journal_title：Biochemical and biophysical research communications

authors： Kawamata M,Katsuda T,Yamada Y,Ochiya T

更新日期：2017-01-22 00:00:00

abstract：:Anthrax-protective antigen is the central moiety of the anthrax toxin complex that mediates the entry of the other two toxin components, lethal factor and edema factor into the cells. It is also the main immunogen of the cell-free vaccine against anthrax. However, in addition to PA, the vaccine contains trace amounts ...

journal_title：Biochemical and biophysical research communications

authors： Ahuja N,Kumar P,Bhatnagar R

更新日期：2001-08-10 00:00:00

abstract：:Small GTPase Rap1 has been implicated in the proper differentiation of testicular germ cells. In the present study, we investigated the functional significance of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in testicular differentiation using mice lacking RA-GEF-2. RA-GEF-2 was expressed predomina...

journal_title：Biochemical and biophysical research communications

authors： Okada K,Miyake H,Yamaguchi K,Chiba K,Maeta K,Bilasy SE,Edamatsu H,Kataoka T,Fujisawa M

更新日期：2014-02-28 00:00:00

abstract：:Deregulation of the expression of human papillomavirus (HPV) oncogenes E6 and E7 plays a pivotal role in cervical carcinogenesis because the E6 and E7 proteins neutralize p53 and Rb tumor suppressor pathways, respectively. In approximately 90% of all cervical carcinomas, HPVs are found to be integrated into the host g...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Lee AY,Kwon YK,Kwon H

更新日期：2011-08-26 00:00:00

abstract：:Lymph node metastasis (LNM) is a critical cause for disease progression and treatment failure in cervical cancer. However, the mechanism underlying cervical cancer LNM remains unclear. In this study, HN1 was found to be dramatically upregulated in cervical cancer and patients with higher HN1 expression are more likely...

journal_title：Biochemical and biophysical research communications

authors： Chen J,Qiu J,Li F,Jiang X,Sun X,Zheng L,Zhang W,Li H,Wu H,Ouyang Y,Chen X,Lin C,Song L,Zhang Y

更新日期：2020-09-10 00:00:00

abstract：:High expression of Rad51, the catalytic component in homologous recombination, has been reported to contribute to genomic instability. To elucidate biological processes related to Rad51, we performed global gene expression analysis on human fibrosarcoma cells induced to express variable Rad51 levels. The results indic...

journal_title：Biochemical and biophysical research communications

authors： Orre LM,Fält S,Szeles A,Lewensohn R,Wennborg A,Flygare J

更新日期：2006-03-10 00:00:00

abstract：:When the F1-ATPase from the thermophilic bacterium, PS3, was inactivated by 90% with 7-chloro-4-nitro[14C]benzofurazan ([14C]Nbf-Cl) at pH 7.3 and then gel-filtered, 1.25 mols of [14C]Nbf-O-Tyr and less than 0.1 mol of Nbf-N-Lys were formed per mol of enzyme. After adjusting the pH of the gel-filtered, modified enzyme...

journal_title：Biochemical and biophysical research communications

authors： Andrews WW,Yoshida M,Hill FC,Allison WS

更新日期：1984-09-28 00:00:00