(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells.

abstract：:2-Amino-3,8-dimethylimidazo(4,5-f)quinoxaline (MeIQx) is a potent mutagen found in cooked food. MeIQx and its isotopically labelled (13C, 15N2 and 14C) analogues were synthesised and used for metabolic studies in vivo. An equimolar mixture of MeIQx and its 13C, 15N2 stable isotope labelled analogue (containing tracer ...

journal_title：Biochemical and biophysical research communications

authors： Gooderham NJ,Watson D,Rice JC,Murray S,Taylor GW,Davies DS

更新日期：1987-11-13 00:00:00

abstract：:The effect of 2,2,2-trifluoroethanol (TFE) on the structure of an all beta-sheet protein, cardiotoxin analogue II (CTX II), from the Taiwan cobra (Naja naja atra) is studied. Using circular dichroism studies, it is found that higher concentrations of TFE induced a structural transition from beta-sheet to alpha-helix, ...

journal_title：Biochemical and biophysical research communications

authors： Jayaraman G,Kumar TK,Arunkumar AI,Yu C

更新日期：1996-05-06 00:00:00

abstract：:To study the role of the cytoplasmic domain and particularly the tyrosine residues of the erythropoietin receptor (EpoR) in erythroid differentiation of human primary stem cells, we infected cord blood-derived CD34+ cells with retroviruses encoding chimeric receptors containing the extracellular domain of the prolacti...

journal_title：Biochemical and biophysical research communications

authors： Fichelson S,Chrétien S,Rokicka-Piotrowicz M,Bouhanik S,Gisselbrecht S,Mayeux P,Lacombe C

更新日期：1999-03-24 00:00:00

abstract：:Transforming growth factor-β (TGF-β) signaling has been significantly implicated in the pathogenesis of aneurysm, prominently the initiation and progression of abdominal aortic aneurysm (AAA). Vascular smooth muscle cell (SMC) is the principal resident cell in aortic wall and is essential for its structure and functio...

journal_title：Biochemical and biophysical research communications

authors： Gao F,Chambon P,Offermanns S,Tellides G,Kong W,Zhang X,Li W

更新日期：2014-11-07 00:00:00

abstract：:Two different types of fumarase were found in sonic extracts of Escherichia coli; one required Fe-S for the enzyme activity, and the other did not. When the cells were grown without aeration, the Fe-S-independent enzyme occupied over 80% of the overall fumarase activity. Highly purified Fe-S-independent enzyme was sug...

journal_title：Biochemical and biophysical research communications

authors： Yumoto N,Tokushige M

更新日期：1988-06-30 00:00:00

abstract：:Temperature is one of the primary environmental factors that affect aging, in which protein phosphorylation is an important regulator. Currently, the understanding of phosphorylation events in regulatory networks during aging has remained rather limited. Herein, the phosphoproteomes of C.elegans of different age group...

journal_title：Biochemical and biophysical research communications

authors： Huang J,Wu Z,Wang J,Zhang X

更新日期：2018-09-10 00:00:00

abstract：:Bone Morphogenetic Proteins (BMPs) strongly induce the recruitment and differentiation of mesenchymal progenitor cells into mature osteoblasts, but also directly and indirectly stimulate differentiation of osteoclast progenitor cells and acceleration of mature osteoclasts function leading excessive bone resorption. Bi...

journal_title：Biochemical and biophysical research communications

authors： Ichikawa K,Ohta Y,Mamoto K,Mizokawa S,Minoda Y,Imai Y,Takaoka K,Nakamura H

更新日期：2016-11-18 00:00:00

abstract：:Cigarette smoke (CS)-induced emphysema is attributable to matrix metalloproteinase-12 (MMP-12) in mice, however, a relationship between CS and MMP-12 is absent in human emphysema. Here, we show that cigarette smoke condensate (CSC) induces MMP-12 gene expression in airway-like epithelia through a hydrogen peroxide (H(...

journal_title：Biochemical and biophysical research communications

authors： Lavigne MC,Eppihimer MJ

更新日期：2005-04-29 00:00:00

abstract：:We have investigated the function of N-terminal and C-terminal domains of the human ETA receptor by expressing truncated mutants in COS-7 cells. Three kinds of ETA receptors truncated in the N-terminal extracellular or C-terminal intracellular domains were produced. Deletion of the entire extracellular N-terminal or i...

journal_title：Biochemical and biophysical research communications

authors： Hashido K,Gamou T,Adachi M,Tabuchi H,Watanabe T,Furuichi Y,Miyamoto C

更新日期：1992-09-30 00:00:00

abstract：:Among the members of the additional sex comb-like (ASXL) family, ASXL3 remains unexplored. Here, we showed that ASXL3 interacts with HP1α and LSD1, leading to transcriptional repression. We determined that ASXL3 depletion augments the ligand-induced transcriptional activities of LXRα and TRβ, which were repressed by A...

journal_title：Biochemical and biophysical research communications

authors： Shin N,Lee YK,Park UH,Jeong JC,Um SJ

更新日期：2014-11-28 00:00:00

abstract：:Antisense oligonucleotides were modified by their ends with hydrophobic substituents which permitted enhancing their activity. The effect of hydrophobized oligonucleotides on reproduction of Herpes Simplex Virus type 1 in Vero cells was studied. Two types of oligonucleotides were used: a 12-mer complementary to the sp...

journal_title：Biochemical and biophysical research communications

authors： Vinogradov SV,Suzdaltseva Y,Alakhov VYu,Kabanov AV

更新日期：1994-09-15 00:00:00

abstract：:PILRα is an immune inhibitory receptor possessing an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain enabling it to deliver inhibitory signals. Binding of PILRα to its ligand CD99 is involved in immune regulation; however, whether there are other PILRα ligands in addition to CD99 is not...

journal_title：Biochemical and biophysical research communications

authors： Kogure A,Shiratori I,Wang J,Lanier LL,Arase H

更新日期：2011-02-18 00:00:00

abstract：:The human leukemia cell line KU812 had been described as an immature prebasophilic cell line and exhibits a potential to differentiate into mature basophils. We studied the effect of interleukin-4 (IL-4) on the basophilic differentiation of KU812 cells. When KU812 cells were cultured with 1 ng/ml IL-4, cellular histam...

journal_title：Biochemical and biophysical research communications

authors： Hara T,Yamada K,Tachibana H

更新日期：1998-06-29 00:00:00

abstract：:Human Cla-1 is the likely homologue of the murine scavenger receptor class B type I (SR-BI). SR-BI mediates selective transfer of cholesterol to high-density lipoprotein (HDL) and the efflux of endogenously synthesized and plasma membrane sterols to HDL. HDL protects against atherosclerosis but also reduces endotoxic ...

journal_title：Biochemical and biophysical research communications

authors： Buechler C,Ritter M,Quoc CD,Agildere A,Schmitz G

更新日期：1999-08-19 00:00:00

abstract：:The Br140 protein was initially identified due to its co-purification with an integrin. We have cloned and sequenced the cDNA corresponding to the Br140 protein. Analysis of the amino acid sequence indicates that Br140 has features characteristic of gene regulatory proteins, including zinc fingers. Furthermore, Br140 ...

journal_title：Biochemical and biophysical research communications

authors： Thompson KA,Wang B,Argraves WS,Giancotti FG,Schranck DP,Ruoslahti E

更新日期：1994-02-15 00:00:00

abstract：:When treated with T3, P19 cells differentiate into ultrastructurally proven cardiac myocytes and express the cardiac ventricular specific marker ventricular myosin light chain 2V. This differentiation is irreversibly induced in culture during the first 48 hrs of exposure to T3. We studied the binding of P19-indigenous...

journal_title：Biochemical and biophysical research communications

authors： Rodriguez ER,Tan CD,Onwuta US,Parrillo JE

更新日期：1994-12-30 00:00:00

abstract：:Incorporation of [3H]-thymidine into DNA in non-synchronized cultures of human endothelial cells was blocked by a 24 h exposure to TNF in a dose dependent manner that resulted in accumulation of cells in G1, as assayed by flow cytometry analysis of DNA content. Proliferation restarted when cells were replated in the a...

journal_title：Biochemical and biophysical research communications

authors： López-Marure R,Bernal AE,Zentella A

更新日期：1997-07-30 00:00:00

abstract：:Under standard conditions, in the presence of GTP, highly purified eIF-2 and Co-eIF-2 factor preparations efficiently stimulated AUG-codon dependent but not physiological mRNA-dependent Met-tRNAf binding to 40S ribosomes. Replacement of GTP by a nonhydrolyzable GTP analog, GMP-PNP, in the above system, gave significan...

journal_title：Biochemical and biophysical research communications

authors： Roy R,Nasrin N,Ahmad MF,Gupta NK

更新日期：1984-08-16 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor 2 (TRAF2) has been demonstrated that it plays a significant role in cell death receptor signal transduction. The purpose of this study was to investigate the expression of TRAF2 and its possible role in FJOA. We observed an up-regulation of TRAF2 in FJOA by immunohistoc...

journal_title：Biochemical and biophysical research communications

authors： Jiang J,Zhang J,Wu C,Guo X,Chen C,Bao G,Sun Y,Chen J,Xue P,Xu G,Cui Z

更新日期：2018-09-10 00:00:00

abstract：:Ecdysone 20-monooxygenase activity and the factors which may regulate this steroid hydroxylase were examined in the midgut of the tobacco hornworm, Manduca sexta, during the last larval stadium. Radioassay experiments revealed that midgut ecdysone 20-monooxygenase undergoes a single 50-fold increase in activity tempor...

journal_title：Biochemical and biophysical research communications

authors： Keogh DP,Johnson RF,Smith SL

更新日期：1989-11-30 00:00:00

abstract：:Recent identification of intracellular proteins that bind ammodytoxin (calmodulin, 14-3-3 proteins, and R25) suggests that this snake venom presynaptically active phospholipase A(2) acts intracellularly. As these ammodytoxin acceptors are cytosolic and mitochondrial proteins, the toxin should be able to enter the cyto...

journal_title：Biochemical and biophysical research communications

authors： Petrovic U,Sribar J,Paris A,Rupnik M,Krzan M,Vardjan N,Gubensek F,Zorec R,Krizaj I

更新日期：2004-11-19 00:00:00

abstract：:The effects of fibroblast growth factor (FGF) on testicular aromatase activity has been studied using primary cultures of porcine Leydig cells. After culture for 3 days in the absence or presence of FGF, the ability of the cells to produce estrogen was examined in a 4h-test period in which either (a) hCG (10(-9) M) or...

journal_title：Biochemical and biophysical research communications

authors： Raeside JI,Berthelon MC,Sanchez P,Saez JM

更新日期：1988-02-29 00:00:00

abstract：:Myeloid leukemia factors (MLF1 and MLF2) are proteins associated with leukemia and several other cancers. However, little is known about the regulatory mechanisms underlying the stability of these proteins. Here, we show that DDB1 and CUL4 associated factor 8 (DCAF8), which can form a functional E3 ligase complex (CRL...

journal_title：Biochemical and biophysical research communications

authors： Huang D,Liu C,Sun X,Sun X,Qu Y,Tang Y,Li G,Tong T

更新日期：2020-08-20 00:00:00

abstract：:The important role of pyruvate kinase during malarial infection has prompted the cloning of a cDNA encoding Plasmodium falciparum pyruvate kinase (pfPyrK), using mRNA from intraerythrocytic-stage malaria parasites. The full-length cDNA encodes a protein with a computed molecular weight of 55.6 kDa and an isoelectric p...

journal_title：Biochemical and biophysical research communications

authors： Chan M,Sim TS

更新日期：2005-01-07 00:00:00

abstract：:We have shown that the orphan receptor Germ Cell Nuclear Factor (GCNF) binds to a direct repeat of the sequence AGGTCA with zero base pair spacing (DR0). Here, we further characterize the binding characteristics of GCNF. We demonstrate that GCNF binds specifically to DR0s as a homodimer, and does not bind with high af...

journal_title：Biochemical and biophysical research communications

authors： Cooney AJ,Hummelke GC,Herman T,Chen F,Jackson KJ

更新日期：1998-04-07 00:00:00

abstract：:Hsa-microRNA-187-3p (miR-187-3p) has recently been discovered having anticancer efficacy in different organs. However, the role of miR-187-3p on non-small cell lung cancer (NSCLC) is still ambiguous. In this study, we investigated the role of miR-187-3p on the development of NSCLC. The results indicated that miR-187-3...

journal_title：Biochemical and biophysical research communications

authors： Sun C,Li S,Yang C,Xi Y,Wang L,Zhang F,Li D

更新日期：2016-02-26 00:00:00

abstract：:Sodium dodecyl sulfate (SDS), a representative anionic surfactant, is a commonly used reagent in studies of the cell membrane and cell wall. However, the mechanisms through which SDS affects cellular functions have not yet been fully examined. Thus, to gain further insights into the cellular functions and responses to...

journal_title：Biochemical and biophysical research communications

authors： Zhao F,Yang J,Li J,Li Z,Lin Y,Zheng S,Liang S,Han S

更新日期：2020-06-18 00:00:00

abstract：:Profilin, an actin-binding protein, was previously described as a ubiquitous allergen which is responsible for cross-reactivities in about 20% of pollen and food allergic patients. A complete cDNA clone coding for timothy grass (Phelum pratense) pollen profilin was isolated using allergic patients IgE. The deduced ami...

journal_title：Biochemical and biophysical research communications

authors： Valenta R,Ball T,Vrtala S,Duchêne M,Kraft D,Scheiner O

更新日期：1994-02-28 00:00:00

abstract：:Two multidrug-resistant human leukemic CCRF-CEM sublines (CEM/VCR R and CEM/VLB100) were significantly more resistant to tetracycline, a hydrophilic antibiotic, than parental cells (P < 0.001). Verapamil and cyclosporin A completely reversed tetracycline resistance in CEM/VCR R cells, which also accumulated and retain...

journal_title：Biochemical and biophysical research communications

authors： Kavallaris M,Madafiglio J,Norris MD,Haber M

更新日期：1993-01-15 00:00:00

abstract：:A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 mumoles of W-7, reaching a maximum of 86% after 5 min. Reduction in sp...

journal_title：Biochemical and biophysical research communications

authors： Nishino H,Fujiki H,Suganuma M,Horiuchi T,Iwashima A,Sugimura T

更新日期：1984-11-14 00:00:00