(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells.

abstract：:Lipoprotein lipase (LPL) catalyzes the hydrolysis of the triacylglycerol component of triacylglycerol-rich lipoproteins. There are 4 cysteine pairs that are completely conserved among LPLs of all species known. We examined the functional importance of each of the cysteine pairs in enzyme catalysis by examining LPLs pr...

journal_title：Biochemical and biophysical research communications

authors： Lo JY,Smith LC,Chan L

更新日期：1995-01-05 00:00:00

abstract：:The PCR analysis followed by sequence alignment showed that both the mineralocorticoid receptor (MCR) and the epithelial sodium channel (ENaC) genes were expressed in the human vascular endothelial cell line (ECV). The growth and multiplication of the ECV in culture were influenced by both aldosterone and the MCR-spec...

journal_title：Biochemical and biophysical research communications

authors： Golestaneh N,Klein C,Valamanesh F,Suarez G,Agarwal MK,Mirshahi M

更新日期：2001-02-09 00:00:00

abstract：:Myosin heavy chain (MHC) mRNA isoforms were quantified in soleus (SOL) and gastrocnemius (GAS) muscles from rats exposed to 14 days of either hindlimb unweighting (HU), clenbuterol treatment (CB), or HU combined with CB treatment (HU-CB). All conditions induced in SOL a shift from slow to faster MHC mRNA isoforms and ...

journal_title：Biochemical and biophysical research communications

authors： Stevens L,Gohlsch B,Mounier Y,Pette D

更新日期：2000-08-28 00:00:00

abstract：:The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast can...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi N,Ito E,Azuma S,Honma R,Yanagisawa Y,Nishikawa A,Kawamura M,Imai J,Tatsuta K,Inoue J,Semba K,Watanabe S

更新日期：2008-01-25 00:00:00

abstract：:The eleven-nineteen lysine-rich leukemia protein (ELL) is a key regulator of RNA polymerase II mediated transcription. ELL facilitates RNA polymerase II transcription pause site entry and release by dynamically interacting with p300 and the positive transcription elongation factor b (P-TEFb). In this study, we investi...

journal_title：Biochemical and biophysical research communications

authors： Fufa TD,Byun JS,Wakano C,Fernandez AG,Pise-Masison CA,Gardner K

更新日期：2015-09-11 00:00:00

abstract：:The current state of the AD research field is highly dynamic is some respects, while seemingly stagnant in others. Regarding the former, our current lack of understanding of initiating disease mechanisms, the absence of effective treatment options, and the looming escalation of AD patients is energizing new research d...

journal_title：Biochemical and biophysical research communications

authors： Briggs CA,Chakroborty S,Stutzmann GE

更新日期：2017-02-19 00:00:00

abstract：:MicroRNAs (miRNAs), small single-stranded regulatory RNAs capable of interfering with intracellular mRNAs that contain partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. MiRNA was originally discovered in the intergenic regions of the Caenorhabditis eleg...

journal_title：Biochemical and biophysical research communications

authors： Ying SY,Lin SL

更新日期：2005-01-21 00:00:00

abstract：:Heparin binding neurite-promoting factor (HBNF) is a highly basic 136 amino acid protein containing 10 cysteine residues. We have determined the redox status and the disulfide arrangement of the cysteine residues in HBNF from bovine brain and refolded human recombinant protein produced in E. coli. Our data indicate th...

journal_title：Biochemical and biophysical research communications

authors： Hulmes JD,Seddon AP,Decker MM,Böhlen P

更新日期：1993-04-30 00:00:00

abstract：:tsBN75 and tsBN423 are independently isolated temperature-sensitive (ts) mutants of the BHK21 cell line for cell growth. Both tsBN75 and tsBN423 belong to the same complementation group and show G2 block at the nonpermissive temperature. Both were efficiently transformed to ts+ cells with the mouse and human cDNA enco...

journal_title：Biochemical and biophysical research communications

authors： Nishitani H,Goto H,Kaneda S,Yamao F,Seno T,Handley P,Schwartz AL,Nishimoto T

更新日期：1992-04-30 00:00:00

abstract：:Deoxynucleoside triphosphate concentrations in Chinese hamster ovary cell lines, CHO-K1 and Mut 8-16, were examined following exposure of cells to UV or dimethylsulfate. Marked decreases in dCTP were observed 2 hr after exposure to both mutagens. In contrast, dTTP concentrations increased with increased cell killing a...

journal_title：Biochemical and biophysical research communications

authors： Newman CN,Miller JH

更新日期：1983-07-18 00:00:00

abstract：:Upon glucose depletion, a massive reprogramming of gene expression occurs in the yeast Saccharomyces cerevisiae for the use of alternate carbon sources such as the nonfermentable compounds ethanol and glycerol. This process is mediated by the master kinase Snf1 that controls the activity of various targets including t...

journal_title：Biochemical and biophysical research communications

authors： Soontorngun N,Baramee S,Tangsombatvichit C,Thepnok P,Cheevadhanarak S,Robert F,Turcotte B

更新日期：2012-07-13 00:00:00

abstract：:Complement sensitization of red blood cells (RBCs) can cause life-threatening hemolytic anemias. We have previously shown that complement receptor 1 (CR1) derivatives specifically the N-terminal region with decay accelerating activity (DAA) for inactivation of a key enzyme in the complement cascade can reduce compleme...

journal_title：Biochemical and biophysical research communications

authors： Yu J,Heck S,Debnath A,Yazdanbakhsh K

更新日期：2007-02-09 00:00:00

abstract：:Determination of the rates of saccharide diffusions by the proteoliposomes showed that the outer membrane of Pseudomonas aeruginosa only possesses small diffusion pores and that protein F might have not been involved in the pore formation. Proteoliposomes containing stachyose or Dextan T-10 showed the same relative di...

journal_title：Biochemical and biophysical research communications

authors： Yoshihara E,Gotoh N,Nakae T

更新日期：1988-10-14 00:00:00

abstract：:Serum leptin levels are elevated in subjects with exogenous obesity, indicating that obesity is associated with leptin resistance. Since in man no abnormalities have yet been found in either the genes for leptin or its receptor, the mechanism of leptin resistance in obesity remains unknown. To determine if resistance ...

journal_title：Biochemical and biophysical research communications

authors： Diamond FB Jr,Eichler DC,Duckett G,Jorgensen EV,Shulman D,Root AW

更新日期：1997-04-28 00:00:00

abstract：:Methotrexate (MTX) is a dihydrofolate reductase (DHFR) inhibitor widely used for treating human cancers, and overexpression of histone deacetylase (HDAC) is usually found in tumors. HDAC inhibitors (HDACi) can reactivate tumor suppressor genes and serve as potential anti-cancer drugs. In this study, we found that MTX ...

journal_title：Biochemical and biophysical research communications

authors： Yang PM,Lin JH,Huang WY,Lin YC,Yeh SH,Chen CC

更新日期：2010-01-15 00:00:00

abstract：:The effect of HMG1 on the transcriptional block caused by left-handed Z-form in a highly negatively supercoiled DNA was examined using a supercoiled plasmid containing a (CG)10 sequence downstream of promoters. The transcription by E. coli RNA polymerase was blocked at the boundary of alternating CG sequence in the Z-...

journal_title：Biochemical and biophysical research communications

authors： Waga S,Mizuno S,Yoshida M

更新日期：1988-05-31 00:00:00

abstract：:The genomic sequence of the halophilic archaeon Halobacterium NRC-1 has been analyzed by the Z curve method. The Z curve is a three-dimensional curve that uniquely represents a given DNA sequence. Based on the known behaviors of the Z curves for the archaea whose replication origins have been identified, the analysis ...

journal_title：Biochemical and biophysical research communications

authors： Zhang R,Zhang CT

更新日期：2003-03-21 00:00:00

abstract：:Our earlier studies on cell adhesion to immobilized carbohydrates are extended here to a marine bacterium, Vibrio furnissii. Apparently one lectin mediates the binding of these cells to glycosides of N-acetylglucosamine, mannose, and glucose covalently linked to Agarose beads. Kinetic studies show that protein synthes...

journal_title：Biochemical and biophysical research communications

authors： Yu C,Lee AM,Roseman S

更新日期：1987-11-30 00:00:00

abstract：:Anti-angiogenic drugs are an effective therapeutic method for the treatment of melanomas. Apatinib is a small-molecule tyrosine kinase inhibitor, which has potent inhibitory activity on tumor angiogenesis. Due to the low water solubility and stability of Apatinib, we aimed to design and develop poly (lactic-co-glycoli...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Liu P,Zhang Z,Han J,Yang X,Wang A,Zhang X

更新日期：2020-01-08 00:00:00

abstract：:Using isolated rat hepatocytes we have shown that glutathione (GSH) depletion by glutathione-S-transferase (GST)-catalyzed conjugation with 1-bromoheptane or phorone was accompanied by a significant elevation in ascorbate synthesis. Glycogenolysis was also stimulated without a significant rise in glucose synthesis. Fu...

journal_title：Biochemical and biophysical research communications

authors： Chan TS,Wilson JX,O'Brien PJ

更新日期：2004-04-23 00:00:00

abstract：:A polymerizable gel superaggregate has been formed from low concentrations (6 mM) of phospholipid mixtures of polymerizable 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine and 1,2-bis(dinonoyl)-sn-glycero-3-phosphocholine. Transmission electron microscopy (TEM) revealed that the superaggregate structure con...

journal_title：Biochemical and biophysical research communications

authors： Markowitz MA,Singh A,Chang EL

更新日期：1994-08-30 00:00:00

abstract：:To characterize mesenchymal stem cells (MSC), we compared gene expression profiles in human bone marrow MSC (11 lines) and human fibroblasts (4 lines) by RT-PCR and real time PCR. Messenger RNA levels of MHC-DR-alpha, MHC-DR-beta, MHC-DR-associated protein CD74, tissue factor pathway inhibitor-2, and neuroserpin were ...

journal_title：Biochemical and biophysical research communications

authors： Ishii M,Koike C,Igarashi A,Yamanaka K,Pan H,Higashi Y,Kawaguchi H,Sugiyama M,Kamata N,Iwata T,Matsubara T,Nakamura K,Kurihara H,Tsuji K,Kato Y

更新日期：2005-06-24 00:00:00

abstract：:We have reported that the principal neutralizing domain of V3 of the HIV-1 gp120 induces an antigen-specific activation apoptosis of responding effector CD4+ T lymphocytes, a phenomenon inhibited by RANTES, an agonist of CCR5. Here, addressing the question of how a hypervariable region could induce such a selective re...

journal_title：Biochemical and biophysical research communications

authors： Baritaki S,Zafiropoulos A,Sioumpara M,Politis M,Spandidos DA,Krambovitis E

更新日期：2002-11-08 00:00:00

abstract：:Sequence analysis of a new lignin peroxidase (LIP) gene, GLG6, from P. chrysosporium showed that it encodes a mature LIP protein with a predicted Mr of 36,454. A 28 aa signal peptide precedes the mature protein. The coding region of GLG6 is interrupted by nine introns ranging in size from 50-57 bp. GLG6 encoded-LIP ha...

journal_title：Biochemical and biophysical research communications

authors： Naidu PS,Zhang YZ,Reddy CA

更新日期：1990-12-31 00:00:00

abstract：:Activation of muscarinic cholinergic receptors on 1321N1 human astrocytoma cells leads to Ca2+ mobilization as measured by quin 2 fluorescence. Acetylcholine and methacholine were full and potent agonists, while carbachol and muscarine, were fully efficacious but 6- and 10-fold less potent than acetylcholine. The carb...

journal_title：Biochemical and biophysical research communications

authors： Noronha-Blob L,Richard C,U'Prichard DC

更新日期：1987-08-31 00:00:00

abstract：:To repress gene transcription, the unliganded nuclear receptor (NR) recruits the N-CoR and SMRT corepressors via its direct association with the conserved motif within bipartite NR-interaction domains (IDs) of corepressors. We recently reported that SMRT is directly involved in the VDR-mediated repression via an ID1-s...

journal_title：Biochemical and biophysical research communications

authors： Kim JY,Son YL,Lee YC

更新日期：2009-02-13 00:00:00

abstract：:The hypothesis, that nucleic acids which code specifically interacting receptor and ligand proteins contain complementary sequences was tested. Human insulin mRNA (HSINSU) contained 16 sequences which were 23.8 +/- 1.4 nucleotides long and were complementary to the insulin receptor mRNA (HSIRPR, 74.8 +/- 1.9% compleme...

journal_title：Biochemical and biophysical research communications

authors： Segerstéen U,Nordgren H,Biro JC

更新日期：1986-08-29 00:00:00

abstract：:The only outer mitochondrial membrane cytochrome b(5) examined to date, from rat (rOM b(5)), exhibits greater stability than known mammalian microsomal (Mc) isoforms, as well as a much higher kinetic barrier for hemin dissociation and a more negative reduction potential. A BlastP search of available databases using th...

journal_title：Biochemical and biophysical research communications

authors： Altuve A,Wang L,Benson DR,Rivera M

更新日期：2004-02-06 00:00:00

abstract：:CD45 is a leukocyte-specific, two domain transmembrane tyrosine phosphatase. Co-purification of a recombinant protein containing the first phosphatase domain of CD45 (6His-D1) with a recombinant protein containing the second phosphatase domain (GST-D2) from E. coli indicated a stable interaction which resulted in incr...

journal_title：Biochemical and biophysical research communications

authors： Felberg J,Johnson P

更新日期：2000-05-10 00:00:00

abstract：:In this report, we describe the expression and function of human Sp5, a member of the Sp family of zinc finger transcription factors. Like other family members, the Sp5 protein contains a Cys2His2 zinc finger DNA binding domain at the C-terminus. Our experiments employing Gal4-Sp5 fusion proteins reveal multiple trans...

journal_title：Biochemical and biophysical research communications

authors： Chen Y,Guo Y,Ge X,Itoh H,Watanabe A,Fujiwara T,Kodama T,Aburatani H

更新日期：2006-02-17 00:00:00