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Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord.

Abstract：

:A novel neurotensin-like peptide, designated neuromedin N, has been isolated from porcine spinal cord by using a bioassay for a stimulant effect on guinea pig ileum. By microsequencing, the amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is found to be quite homologous to the COOH-terminal sequence of neurotensin. This structure has been confirmed by synthesis. Neuromedin N exhibits a contractile activity on guinea pig ileum and induces a hypotensive response in the rat similar to that with neurotensin. These findings suggest that neuromedin N may be a new neuromediator or hormone with a specific spectrum of biological activity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Minamino N,Kangawa K,Matsuo H

doi

10.1016/s0006-291x(84)80067-4

subject

Has Abstract

pub_date

1984-07-31 00:00:00

pages

542-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)80067-4

journal_volume

122

pub_type

杂志文章

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