Blood group A glycolipid (Ax) with globo-series structure which is specific for blood group A1 erythrocytes: one of the chemical bases for A1 and A2 distinction.

abstract：AIM:To investigate the effect of endogenous PTH deficiency on osteoclasts during fracture healing and its mechanism. METHODS:A femoral fracture model was used to determine the role of endogenous PTH in fracture healing. Immunohistochemistry, qPCR, and Western blot were used to determine the potential functions and mec...

journal_title：Biochemical and biophysical research communications

authors： Sun P,Wang M,Yin GY

更新日期：2020-05-14 00:00:00

abstract：:Angiopoietin-2 (Ang-2) plays an important role in destabilizing vessels for angiogenesis, however its transcriptional regulation has not been determined. Here we isolated about 3.2kb of the 5' upstream of the human Ang-2 gene and further characterized the transcriptional regulation of Ang-2. We found 10 Ets binding si...

journal_title：Biochemical and biophysical research communications

authors： Hasegawa Y,Abe M,Yamazaki T,Niizeki O,Shiiba K,Sasaki I,Sato Y

更新日期：2004-03-26 00:00:00

abstract：:Ascorbate peroxidase (APX) is a hydrogen peroxide-scavenging peroxidase which uses ascorbate (AsA) as the specific electron donor. APX has not been isolated in mammals. Ocular tissue contains AsA at high concentrations, and we detected APX activity in bovine retinal pigment epithelium (RPE) and choroid. We purified AP...

journal_title：Biochemical and biophysical research communications

authors： Wada N,Kinoshita S,Matsuo M,Amako K,Miyake C,Asada K

更新日期：1998-01-14 00:00:00

abstract：:Resident mouse peritoneal macrophages in culture spontaneously secrete lipoprotein lipase. Secretion of lipoprotein lipase was 10-fold greater in thioglycollate-elicited and 6-fold greater in mineral oil-elicited macrophages. The increase in enzyme secretion was dependent on protein synthesis and glycosylation of the ...

journal_title：Biochemical and biophysical research communications

authors： Goldberg DI,Khoo JC

更新日期：1987-01-15 00:00:00

abstract：:Interaction of camel lens zeta-crystallin with aspirin was investigated by activity and fluorescence measurements. Aspirin minimally inhibited the oxidoreductase activity of the enzyme and weakly quenched its fluorescence. However, significant fluorescence quenching of zeta-crystallin coincided with the appearance of ...

journal_title：Biochemical and biophysical research communications

authors： Bazzi MD

更新日期：2002-04-26 00:00:00

abstract：:Recent structural investigations on the beta-1,4-galactosyltransferase-1 (Gal-T1) and lactose synthase (LS) have revealed that they are akin to an exquisite mechanical device with two well-coordinated flexible loops that are contained within the Gal-T1 catalytic domain. The smaller one has a Trp residue (Trp314) flank...

journal_title：Biochemical and biophysical research communications

authors： Ramakrishnan B,Boeggeman E,Qasba PK

更新日期：2002-03-15 00:00:00

abstract：:By using a radioimmunoassay (RIA) system newly established for human brain natriuretic peptide (BNP), a high concentration of immunoreactive (ir-) human BNP (hBNP) has been found in cardiac atrium (1). Two molecular forms of ir-hBNP of 4K and 13-15K were isolated from atrial extracts by using anti-hBNP IgG immunoaffin...

journal_title：Biochemical and biophysical research communications

authors： Hino J,Tateyama H,Minamino N,Kangawa K,Matsuo H

更新日期：1990-03-16 00:00:00

abstract：:Experimental studies have demonstrated the beneficial effects of tetramethylpyrazine (TMP) against ischemic stroke and highlighted its crucial role in anti-inflammatory activity. This study provides evidence of an alternative target for TMP and sheds light on the mechanism of its anti-inflammatory action against ische...

journal_title：Biochemical and biophysical research communications

authors： Chang CY,Kao TK,Chen WY,Ou YC,Li JR,Liao SL,Raung SL,Chen CJ

更新日期：2015-07-31 00:00:00

abstract：:The expression of sucrase-isomaltase mRNA was investigated along the crypt-villus axis of rat small intestine using differentially isolated cells and in situ hybridization. A partial rat sucrase-isomaltase cDNA was cloned which coded for a protein that was predicted to be 88% homologous to those encoded by the rabbit ...

journal_title：Biochemical and biophysical research communications

authors： Traber PG

更新日期：1990-12-31 00:00:00

abstract：:Our previous studies demonstrated that intravenous administration of staphylococcal enterotoxin B (SEB) to BALB/c mice resulted in thymocyte apoptosis. In the present study, we evaluated the role of protein kinase C (PKC) in thymocyte apoptosis induced by SEB. Our results showed that the level of protein phosphorylati...

journal_title：Biochemical and biophysical research communications

authors： Lin YS,Kao SF,Jan MS,Cheng ML,Wing LY,Chang WC,Lei HY,Lin MT

更新日期：1995-08-24 00:00:00

abstract：:The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast can...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi N,Ito E,Azuma S,Honma R,Yanagisawa Y,Nishikawa A,Kawamura M,Imai J,Tatsuta K,Inoue J,Semba K,Watanabe S

更新日期：2008-01-25 00:00:00

abstract：:The syndrome of generalized epilepsy with febrile seizures plus type 1 (GEFS+) has been associated to the gene SCN1B coding for the sodium channel beta1 subunit (Wallace, R. H. et al. (1998) Nature Genetics 19, 366-370). In patients, a mutation of the cysteine 121 to trpyptophane (C121W) would cause a lack of modulato...

journal_title：Biochemical and biophysical research communications

authors： Moran O,Conti F

更新日期：2001-03-23 00:00:00

abstract：:We have used RT-PCR with degenerate transmembrane primers to clone members of the G-coupled protein receptor family from rat hypothalamic suprachiasmatic nuclei. We report here a novel clone, UHR-1, which encodes a candidate receptor that is most similar to the neuropeptide receptor family, including the tachykinins, ...

journal_title：Biochemical and biophysical research communications

authors： Welch SK,O'Hara BF,Kilduff TS,Heller HC

更新日期：1995-04-17 00:00:00

abstract：:Chemotherapeutic efficacy is also regulated by the tumor microenvironment. IL-6 produced by TAMs and downstream IL-6/STAT3 signaling pathway is central regulator in chemotherapeutic response. The M2-like phenotype of TAMs is characterized by elevated iron uptake. Whether iron participates in chemo-resistance need to b...

journal_title：Biochemical and biophysical research communications

authors： Li J,He K,Liu P,Xu LX

更新日期：2016-06-24 00:00:00

abstract：:Manganese superoxide dismutase (GP-MnSOD), a component of the so-called 'green protein' (green protein complex) from the facultative anaerobic halodenitrifier Bacillus halodenitrificans, has been crystallized using the hanging-drop vapor diffusion method. Crystals have unit-cell parameters a=b=93.4 A, c=65.0 A, and be...

journal_title：Biochemical and biophysical research communications

authors： Liao J,Li M,Liu MY,Chang T,Le Gall J,Gui LL,Zhang JP,Liang DC,Chang WR

更新日期：2002-05-31 00:00:00

abstract：:Enzyme activity in rat serum was examined utilizing the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and various glycerolipids as substrates. The serum activity was specific for hydrolysis of the long chain tetradecanoate moiety of TPA, hydrolyzed mono- and diacylglycerols, but was not effective ag...

journal_title：Biochemical and biophysical research communications

authors： Cabot MC

更新日期：1984-08-30 00:00:00

abstract：:Prior studies have identified molecules involved in IL-1 signaling that transmit the extracellular stimulus to downstream kinase molecules causing altered transcriptional activity. Many of these investigations have relied heavily on ligand induced protein-protein interactions detected by immuno-coprecipitation to map ...

journal_title：Biochemical and biophysical research communications

authors： Boch JA,Yoshida Y,Koyama Y,Wara-Aswapati N,Peng H,Unlu S,Auron PE

更新日期：2003-04-04 00:00:00

abstract：:GPR109A (PUMA-G, NIACR1, HCA(2)) and GPR81 (HCA(1)) are G protein-coupled receptors located predominantly on adipocytes that mediate anti-lipolytic effects. These cell surface receptors give the adipocyte the ability to "sense" metabolic changes in the environment and respond through lipolytic regulation and release o...

journal_title：Biochemical and biophysical research communications

authors： Wanders D,Graff EC,Judd RL

更新日期：2012-08-24 00:00:00

abstract：:We have investigated the role of arachidonic acid metabolites in the regulation of interleukin-1 production by murine peritoneal macrophages. Indomethacin a potent inhibitor of prostaglandin synthesis caused a dose-dependent augmentation of lipopolysaccharide induced interleukin production (up to 7-fold at 5 microM). ...

journal_title：Biochemical and biophysical research communications

authors： Kunkel SL,Chensue SW

更新日期：1985-04-30 00:00:00

abstract：:Heat stable enterotoxins (STs) are low molecular-weight peptides secreted by enterotoxigenic bacteria. One type of these enterotoxins (STa) induces intestinal secretion leading to acute diarrhea by binding to a membrane form of guanylate cyclase. We have isolated a cDNA from a human colonic cell line, T84, encoding fo...

journal_title：Biochemical and biophysical research communications

authors： Singh S,Singh G,Heim JM,Gerzer R

更新日期：1991-09-30 00:00:00

abstract：:SARS-CoV 3CL protease is essential for viral protein processing and is regarded as a good drug target to prevent SARS-CoV replication. In the present study, we established a high-throughput FRET technique for screening for anti-SARS-CoV 3CL protease drugs. Of a thousand existing drugs examined, hexachlorophene was ide...

journal_title：Biochemical and biophysical research communications

authors： Liu YC,Huang V,Chao TC,Hsiao CD,Lin A,Chang MF,Chow LP

更新日期：2005-07-22 00:00:00

abstract：:Diabetic cardiomyopathy is an essential complication of diabetes and characterized by persistent diastolic dysfunction, leading to myocardial fibrosis. Oxidative stress and inflammation lead to cell damage and are implicated in many disease states. In our study, we evaluated the effects of toll-like receptor 6 (TLR6) ...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Zhang Y

更新日期：2016-04-29 00:00:00

abstract：:alpha-Acaridial [2(E)-(4-methyl-3-pentenyl)butenedial] is a novel monoterpene secreted from the house dust mites. Because of its molecular nature of a highly reactive, small lipidic compound, we addressed whether alpha-acaridial might function as a haptenic allergen that induced allergic contact dermatitis. Mice sensi...

journal_title：Biochemical and biophysical research communications

authors： Sasai T,Hirano Y,Maeda S,Matsunaga I,Otsuka A,Morita D,Nishida R,Nakayama H,Kuwahara Y,Sugita M,Mori N

更新日期：2008-10-24 00:00:00

abstract：:Exogenous angiogenin undergoes rapid nuclear translocation in cultured human umbilical artery endothelial cells at 37 degrees C but not at 4 degrees C. Treatment of cells with colchicine, nocodazole and taxol, which disrupt the microtubule system, does not affect the nuclear translocation process of angiogenin, sugges...

journal_title：Biochemical and biophysical research communications

authors： Li R,Riordan JF,Hu G

更新日期：1997-09-18 00:00:00

abstract：:Methanococcus voltae produces two flagellins of molecular weight 31,000 and 33,000. Amino acid analysis as well as peptide mapping with cyanogen bromide, chymotrypsin and Staphylococcus aureus V-8 protease indicates that the two flagellins are distinct. N-terminal sequencing of the 31,000 Mc. voltae flagellin as well ...

journal_title：Biochemical and biophysical research communications

authors： Kalmokoff ML,Karnauchow TM,Jarrell KF

更新日期：1990-02-28 00:00:00

abstract：:Pelvic cartilage of chick embryo was used to demonstrate that presence of boron in culture medium decreases synthesis of proteoglycans, collagen and total proteins but on the other hand increases the release of these macromolecules. However, when glucose concentration in culture medium is brought to 22mM, the synthesi...

journal_title：Biochemical and biophysical research communications

authors： Benderdour M,Hess K,Gadet MD,Dousset B,Nabet P,Belleville F

更新日期：1997-05-08 00:00:00

abstract：:Antibody-based targeted therapy of cancers requires the antibody targeting of specific molecules inducing tumor cells apoptosis or death. Angiopoietin-2 (Agn-2) and translocator protein (TSPO) are identified as potential target molecules for glioblastoma therapy. The single chain anti-Agn-2 antibody (Anag-2) and anti-...

journal_title：Biochemical and biophysical research communications

authors： Li J,Zhang Z,Lv L,Qiao H,Chen X,Zou C

更新日期：2016-04-01 00:00:00

abstract：:DNA cleavage by N-(O,O-diisopropyl)phosphoryl histidine(DIPP-His) is investigated by a submarine agarose electrophoresis technique. It was found that DIPP-His could cleave supercoiled DNAs and lambda DNA without the participation of divalent metal ions, while the histidine itself and N-(O,O-diisopropyl)phosphoryl alan...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Sha YW,Ma Y,Zhao Y

更新日期：1995-08-24 00:00:00

abstract：:BRCA1-BRCA2-containing complex subunit 3 (BRCC3), a Lys-63-specific deubiquitinase, is a member of the JAMM/MPN family of zinc metalloproteases. BRCC3 have been shown to promote the inflammasome activation by deubiquitinating NOD-like receptor containing pyrin domain 3 (NLRP3). We reported the involvement of neuronal ...

journal_title：Biochemical and biophysical research communications

authors： Cheng X,Xu S,Zhang C,Qin K,Yan J,Shao X

更新日期：2020-02-12 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, is highly expressed in the myocardium under various stimuli including hypoxia and ischemia. On the other hand, lipopolysaccharide (LPS) causes systemic inflammatory response syndrome (SIRS), which consists of systemic pathophysiolog...

journal_title：Biochemical and biophysical research communications

authors： Sugishita Y,Shimizu T,Yao A,Kinugawa Ki,Nojiri T,Harada K,Matsui H,Nagai R,Takahashi T

更新日期：2000-02-16 00:00:00