Abstract:
:A new blood group A-active glycolipid fraction, termed Ax, showing a chromatographic mobility between Aa and Ab was found in blood group A1 erythrocytes but not in A2 erythrocytes. Ax was identified by its conversion to "globo H" by alpha-N-acetylgalactosaminidase and by 1H-NMR spectroscopy as GalNAc alpha l----3[Fuc alpha l----2]Gal beta l----3GalNAc beta l----3Gal alpha l----4Gal beta l----4Glc beta l----lCer. Globo-H (Fuc alpha l----2Gal beta l----3GalNac beta l----3Gal alpha l----4Gal beta l----4Glc beta l----lCer) was found in blood group A, and O but not in A1 erythrocytes. Thus, one of the A1-specific determinants must be an A determinant carried by globo-series structure.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Clausen H,Watanabe K,Kannagi R,Levery SB,Nudelman E,Arao-Tomono Y,Hakomori Sdoi
10.1016/0006-291x(84)91585-7subject
Has Abstractpub_date
1984-10-30 00:00:00pages
523-9issue
2eissn
0006-291Xissn
1090-2104pii
0006-291X(84)91585-7journal_volume
124pub_type
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