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Alterations in the creatine kinase system in the myocardium of cardiomyopathic hamsters.

Abstract：

:Immunochemical and biochemical methods were used to assess quantitatively the changes in the heart creatine kinase system in the myopathic Syrian hamsters, line CHF I46. Cardiomyopathy in I75-200 day old animals was characterized by decreased content of mitochondria and lower total creatine kinase activity. In isolated mitochondria only the creatine kinase activity was decreased while cytochromes aa3 content and respiration rate were unchanged. The share of mitochondrial creatine kinase in the total tissue enzyme activity was decreased from 33% to I8% and that of BB form was elevated from 5% in control to 20%, at unchanged relative level of MM. Immunoassay showed decreased amount of the mitochondrial creatine kinase in the tissue and its decreased ratio to cytochromes aa3. The results show altered expression of creatine kinase isoenzymes in cardiomyopathy.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Khuchua ZA,Ventura-Clapier R,Kuznetsov AV,Grishin MN,Saks VA

doi

10.1016/s0006-291x(89)80030-0

subject

Has Abstract

pub_date

1989-12-15 00:00:00

pages

748-57

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(89)80030-0

journal_volume

165

pub_type

杂志文章

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