Cloning and characterization of the 5'-flanking region of the Ehox gene.

abstract：:Our previous report has shown that honokiol (HNK), a constituent of Magnolia officinalis, induces a novel form of non-apoptotic programmed cell death in human leukemia NB4 and K562 cells. In this study, we further explored the relationship between the cell death pathway and cytoplasmic vacuolization and studied the un...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Zhu X,Yang Z,Zhao X

更新日期：2013-01-18 00:00:00

abstract：:Extracellular superoxide dismutase (EC-SOD) is the major isozyme of SOD in arteries, but is also abundant in lungs. In particular, mouse lungs contain large amounts of EC-SOD compared to lungs in other mammals. This suggests that EC-SOD may have an amplified function in the mouse lung. This study describes the purific...

journal_title：Biochemical and biophysical research communications

authors： Fattman CL,Enghild JJ,Crapo JD,Schaefer LM,Valnickova Z,Oury TD

更新日期：2000-08-28 00:00:00

abstract：:Biochemical studies revealed that the novel rice plant-specific kinesin K16 has several unique enzymatic characteristics as compared to conventional kinesins. The ADP-free form of K16 is very stable, whereas the ADP-free form of conventional kinesins is labile. In the present study, the crystal structure of the novel ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka K,Umeki N,Mitsui T,Fujimoto Z,Maruta S

更新日期：2010-10-15 00:00:00

abstract：:Enzymatic properties of phosphorylated urokinase plasminogen activator (P-uPA) (1) extracted from human carcinomatous cell line Detroit 562 cells were compared with those of non-phosphorylated uPA of urinary origin (nP-uPA). Using plasminogen as a substrate, the Km and Kcat of P-uPA were higher than that of nP-uPA whi...

journal_title：Biochemical and biophysical research communications

authors： Takahashi K,Kwaan HC,Koh E,Tanabe M

更新日期：1992-02-14 00:00:00

abstract：:B7-H3, an immunoregulatory protein, has been found highly expressed in several cancer types, and involved in cancer cell migration and invasion. Here, we investigated the role of B7-H3 in oxaliplatin resistance in colorectal cancer (CRC) cells. Transient silencing of B7-H3 enhanced oxaliplatin sensitivity by increasin...

journal_title：Biochemical and biophysical research communications

authors： Zhang P,Chen Z,Ning K,Jin J,Han X

更新日期：2017-08-26 00:00:00

abstract：:Mannoproteins (MPs) are a major component of yeast cell walls and consist of high levels of mannose in covalent complexes with proteins. MPs complexly enhance the immune system. We previously isolated a mutant yeast, K48L3, with a higher yield of MP from its cell wall than wild-type Saccharomyces cerevisiae, YPH499. W...

journal_title：Biochemical and biophysical research communications

authors： Yoon BH,Lee SM,Chang HI,Ha CH

更新日期：2019-11-19 00:00:00

abstract：:Xanthurenic acid is an endogenous molecule leading to caspase-9 and -3 activation. Here we report that xanthurenic acid targets signalling proteins 14-3-3 into lysosomes leading to interruption protein/protein interaction. Xanthurenic acid changed the localisation of 14-3-3 in the cells. At a concentration of 10 and 2...

journal_title：Biochemical and biophysical research communications

authors： Malina HZ,Frueh BE

更新日期：2003-10-17 00:00:00

abstract：:Nuclear migration in Arabidopsis root hairs is bidirectional and relies on actin filaments. However, how actin filaments regulate the bidirectional movement of nuclei remains unclear. Here, we discovered that nuclei migrate forward and backward according to the developmental stage of the hair cells. In addition, the m...

journal_title：Biochemical and biophysical research communications

authors： Zhang S,Liu J,Xue X,Tan K,Wang C,Su H

更新日期：2019-11-19 00:00:00

abstract：:Small ubiquitin-like modifiers (SUMOs) are proteins homologous to ubiquitin that possibly regulate intranuclear protein localization, nuclear transport, and ubiquitination. We examined patients of DRPLA, SCA1, MJD, and Huntington's disease and found that neurons in affected regions of the brain react strongly to SUMO-...

journal_title：Biochemical and biophysical research communications

authors： Ueda H,Goto J,Hashida H,Lin X,Oyanagi K,Kawano H,Zoghbi HY,Kanazawa I,Okazawa H

更新日期：2002-04-26 00:00:00

abstract：:The molecular mechanisms of the endothelial fibrinolytic activities modulated by mechanical strain are not clear. Endothelial cells (ECs) grown on a flexible membrane base were deformed with sinusoidal negative pressures to produce an average strain of 12%. Cyclic strain induced PAI-1 release in a time-dependent manne...

journal_title：Biochemical and biophysical research communications

authors： Cheng JJ,Chao YJ,Wung BS,Wang DL

更新日期：1996-08-05 00:00:00

abstract：:Bone marrow stromal cell antigen 2 (BST-2) is a type II transmembrane protein that is known to be a therapeutic target in several types of cancer. However, despite its clinical importance, the roles of BST-2 expression have remained elusive. Here, we found that BST-2 expression is up-regulated in tamoxifen-resistant M...

journal_title：Biochemical and biophysical research communications

authors： Yi EH,Yoo H,Noh KH,Han S,Lee H,Lee JK,Won C,Kim BH,Kim MH,Cho CH,Ye SK

更新日期：2013-06-14 00:00:00

abstract：:The Na(+)/K(+) ATPase generates the Na(+) and K(+) concentration gradients across the plasma membrane and is thus essential for cellular electrolyte homeostasis, cell membrane potential and cell volume maintenance. A powerful regulator of Na(+)/K(+) ATPase is the serum- and glucocorticoid-inducible kinase 1 (SGK1). Th...

journal_title：Biochemical and biophysical research communications

authors： Hosseinzadeh Z,Schmid E,Shumilina E,Laufer S,Borst O,Gawaz M,Lang F

更新日期：2014-09-26 00:00:00

abstract：:Pancreatic adenocarcinoma is currently one of the leading causes of cancer-related death worldwide. The high rate of mortality in pancreatic cancer patients is due to the inability to detect early-stage disease and the disease being highly refractory to therapy. Gemcitabine has been the standard chemotherapy for advan...

journal_title：Biochemical and biophysical research communications

authors： Ahn HM,Kim DG,Kim YJ

更新日期：2020-06-25 00:00:00

abstract：:Activation of the transcription factor NF-kappaB results in protection against apoptosis, and the chemotherapeutic agent 5-Fluorouracil (5-FU) exerts its cytotoxic effect through the induction of apoptosis. Thus, we examined whether 5-FU could induce apoptosis through the suppression of NF-kappaB activity. We found th...

journal_title：Biochemical and biophysical research communications

authors： Aota K,Azuma M,Yamashita T,Tamatani T,Motegi K,Ishimaru N,Hayashi Y,Sato M

更新日期：2000-07-14 00:00:00

abstract：:Monoclonal antibodies against chick embryonic beta-galactoside-binding lectin were obtained. One of the monoclonal antibodies was ineffective in Western blotting and seemed to be unable to bind the SDS-denatured lectin. When the native lectin was dotted on a nitrocellulose filter and subjected to denaturation by treat...

journal_title：Biochemical and biophysical research communications

authors： Oda Y,Kasai K

更新日期：1984-09-28 00:00:00

abstract：:To further define the molecular interaction between decorin and type I collagen we generated a 20 kD fragment containing the N-terminal half of the core protein by Endoproteinase Arg C digestion and a 40 kD fragment including all leucine-rich repeats in the central part of decorin core by cleavage with 2-nitro-5-thioc...

journal_title：Biochemical and biophysical research communications

authors： Pogány G,Vogel KG

更新日期：1992-11-30 00:00:00

abstract：:Starch branching enzyme (SBE) catalyzes the cleavage of α-1,4-linkages and the subsequent transfer of α-1,4 glucan to form an α-1,6 branch point in amylopectin. We determined the crystal structure of the rice branching enzyme I (BEI) in complex with maltopentaose at a resolution of 2.2Å. Maltopentaose bound to a hydro...

journal_title：Biochemical and biophysical research communications

authors： Chaen K,Noguchi J,Omori T,Kakuta Y,Kimura M

更新日期：2012-08-03 00:00:00

abstract：:Gout patients receiving a combination of allopurinol and furosemide require higher allopurinol doses to achieve the target serum urate (SU) of <6 mg/dl (Stamp et al., 2012) [1]. Our study aimed to identify the molecular basis for this observation. We used a fluorimetric assay to determine the impact of furosemide and ...

journal_title：Biochemical and biophysical research communications

authors： Knake C,Stamp L,Bahn A

更新日期：2014-09-12 00:00:00

abstract：:A well-established feature of the translation initiation region, which attracts the ribosomes to the prokaryotic mRNAs, is a purine rich area called Shine/Dalgarno sequence (SD). There are examples of various other sequences, which despite having no similarity to an SD sequence are capable of enhancing and/or initiati...

journal_title：Biochemical and biophysical research communications

authors： Golshani A,Krogan NJ,Xu J,Pacal M,Yang XC,Ivanov I,Providenti MA,Ganoza MC,Ivanov IG,AbouHaidar MG

更新日期：2004-04-16 00:00:00

abstract：:A strong overlap exists between gp170 and CYP3A substrates and inducers. In order to investigate a putative coregulation of MDR and CYPA gene expression, we measured their transcripts in human liver and after dexamethasone treatment in HepG2 cells or in different mouse tissues. In human liver, we observed no correlati...

journal_title：Biochemical and biophysical research communications

authors： Sérée E,Villard PH,Hevér A,Guigal N,Puyoou F,Charvet B,Point-Scomma H,Lechevalier E,Lacarelle B,Barra Y

更新日期：1998-11-18 00:00:00

abstract：:Alzheimer disease (AD) is a heterogeneous disorder with a variety of molecular pathologies converging predominantly on abnormal amyloid deposition particularly in the brain. beta-Amyloid aggregation into senile plaques is one of the pathological hallmarks of AD. beta-Amyloid is generated by a proteolytic cleavage of a...

journal_title：Biochemical and biophysical research communications

authors： Elbaum D,Brzyska M,Bacia A,Alkon DL

更新日期：2000-01-27 00:00:00

abstract：:The energization of rho + and rho degrees isolated mitochondria was measured using a tetraphenylphosphonium selective electrode. In both strains translocase mediated ATP/ADP exchange energization was observed. This energization was more sensitive to uncoupler than that induced by respiration in rho + mitochondria. Thi...

journal_title：Biochemical and biophysical research communications

authors： Dupont CH,Mazat JP,Guerin B

更新日期：1985-11-15 00:00:00

abstract：AIMS:Mutations in 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) result in lipodystrophy, insulin resistance and diabetes. Autophagy is required for normal adipogenesis and adipose tissue development. The aim of this study was to determine whether impaired autophagy or excessive cell death underlie the adipoge...

journal_title：Biochemical and biophysical research communications

authors： Fernández-Galilea M,Tapia P,Cautivo K,Morselli E,Cortés VA

更新日期：2015-11-06 00:00:00

abstract：:A representative phenotype of patients with tricho-rhino-phalangeal syndrome (TRPS) is sparse hair. To understand the developmental defects of these patient's hair follicles, we analyzed the development of hair follicles histologically and biochemically using Trps1 deficient (KO) mice. First, we compared the numbers o...

journal_title：Biochemical and biophysical research communications

authors： Sun Y,Nakanishi M,Sato F,Oikawa K,Muragaki Y,Zhou G

更新日期：2015-01-16 00:00:00

abstract：:Serine palmitoyltransferase long chain-1 (SPTLC1), which is the rate-limiting enzyme for sphingolipid biosynthesis, has been indicated to be essential for carcinoma cell survival and proliferation in recent, but its role in the regulation of renal cell carcinoma (RCC) remains unknown. In the present study, we found th...

journal_title：Biochemical and biophysical research communications

authors： Kong Z,Guo X,Zhao Z,Wu W,Luo L,Zhu Z,Yin S,Cai C,Wu W,Wang D,Liu Y,Duan X

更新日期：2019-11-26 00:00:00

abstract：:Adiponectin, an adipocyte-derived hormone, attenuates the production of TNFalpha by activated human macrophages. In the present study, we used porcine blood-derived macrophages to test the hypothesis that the anti-inflammatory action of adiponectin includes suppression of IL6 and an induction of IL10. Adiponectin supp...

journal_title：Biochemical and biophysical research communications

authors： Wulster-Radcliffe MC,Ajuwon KM,Wang J,Christian JA,Spurlock ME

更新日期：2004-04-09 00:00:00

abstract：:S-Nitrosylation emerges as an important protein modification in many processes. However, most data were obtained at the protein level after addition of a NO donor, particularly in plants where information about the cysteines nitrosylated in these proteins is scarce. An adapted work-flow, combining the classical biotin...

journal_title：Biochemical and biophysical research communications

authors： Fares A,Rossignol M,Peltier JB

更新日期：2011-12-16 00:00:00

abstract：:PSI domains are cysteine-rich modules found in extracellular fragments of hundreds of signaling proteins, including plexins, semaphorins, integrins, and attractins. Here, we report the solution structure of the PSI domain from the human Met receptor, a receptor tyrosine kinase critical for proliferation, motility, and...

journal_title：Biochemical and biophysical research communications

authors： Kozlov G,Perreault A,Schrag JD,Park M,Cygler M,Gehring K,Ekiel I

更新日期：2004-08-13 00:00:00

abstract：:Substantial evidence suggests that peroxynitrite generated from the bi-radical reaction of nitric oxide and superoxide is critically involved in the pathogenesis of neurodegenerative disorders, such as Parkinson's disease. Reaction with sulfhydryl (SH)-containing molecules has been proposed to be a major detoxificatio...

journal_title：Biochemical and biophysical research communications

authors： Cao Z,Hallur S,Qiu HZ,Peng X,Li Y

更新日期：2004-04-16 00:00:00

abstract：:Microbial RNases along with such animal RNases as onconase and BS-RNase are a promising basis for developing new antitumor drugs. We have shown that the Bacillus intermedius RNase (binase) induces selective apoptosis of transformed myeloid cells. It attacks artificially expressing activated c-Kit myeloid progenitor FD...

journal_title：Biochemical and biophysical research communications

authors： Ilinskaya ON,Zelenikhin PV,Petrushanko IY,Mitkevich VA,Prassolov VS,Makarov AA

更新日期：2007-10-05 00:00:00