Inhibition of B7-H3 reverses oxaliplatin resistance in human colorectal cancer cells.

abstract：:An E. coli mutant deficient in organophosphonate biodegradation has been complemented with a cosmid library prepared from a BamHI partial digest of wild-type E. coli W3110. Mutant E. coli SL724, when transformed with cosmid pSL163 and plasmid pSL263, regained the ability to exploit ethylphosphonate as a sole source of...

journal_title：Biochemical and biophysical research communications

authors： Loo SH,Peters NK,Frost JW

更新日期：1987-10-14 00:00:00

abstract：:Protein-binding DNA-regions inside and in the vicinity of the phenobarbital-inducible P450bm-3 gene from Bacillus megaterium were characterized by gel-retardation technique and foot-printing analysis. Regions with induction-dependent protein binding capacity were shown to be situated in -279bp/-215bp, -215bp/+83bp and...

journal_title：Biochemical and biophysical research communications

authors： Gaidamakova EK,Karginov VA,Kovalenko SP

更新日期：1994-02-15 00:00:00

abstract：:Metabolic deregulation accompanying type II diabetes is characterized by insulin resistance in peripheral tissues (liver, muscle, and adipose), mediated by impairments in insulin receptor (IR) signaling. Protein tyrosine phosphatase 1B (PTP1B) has been shown to be a negative regulator of IR autophosphorylation and thu...

journal_title：Biochemical and biophysical research communications

authors： Xu J,Li L,Qian Z,Hong J,Shen S,Huang W

更新日期：2005-04-08 00:00:00

abstract：:Flowers have distinct glycerolipid composition, yet its floral organ-specific profile remains elusive in Arabidopsis whose flowers are too tiny to dissect different floral organs. Here, we employed known floral homeotic mutants agamous-1 (ag-1) and apetala3-3 (ap3-3) to facilitate sample preparation enriched in differ...

journal_title：Biochemical and biophysical research communications

authors： Nakamura Y,Liu YC,Lin YC

更新日期：2014-08-08 00:00:00

abstract：:Lysosomal integral membrane protein-2 (LIMP-2) is a type III transmembrane protein that is highly glycosylated and mainly localized to the lysosomal membrane. The diverse functions of LIMP-2 are currently being uncovered; however, its participation in macroautophagy, usually described as autophagy, has not yet been we...

journal_title：Biochemical and biophysical research communications

authors： Sakane H,Urabe J,Nakahira S,Hino K,Miyata N,Akasaki K

更新日期：2020-12-17 00:00:00

abstract：:Somatic mutations of the fibroblast growth factor receptor 3 (FGFR3) gene were detected by peptide nucleic acid (PNA)-mediated real-time PCR clamping. Mutation was detected in negative control containing only wild-type DNA due to a misincorporation of dNTPs to PNA binding sites when the amount of template DNA was decr...

journal_title：Biochemical and biophysical research communications

authors： Miyake M,Sugano K,Kawashima K,Ichikawa H,Hirabayashi K,Kodama T,Fujimoto H,Kakizoe T,Kanai Y,Fujimoto K,Hirao Y

更新日期：2007-11-03 00:00:00

abstract：:In rat adrenal dispersed cells, both vanadyl and vanadate inhibited ACTH-stimulated steroidogenesis and the formation of cAMP, whereas these compounds did not inhibit the cAMP-dependent steroidogenesis. Then, the membrane fraction was prepared and activated by various secretagogues including ACTH, Gpp(NH)p, GTP gamma ...

journal_title：Biochemical and biophysical research communications

authors： Hayashi Y,Kimura T

更新日期：1985-08-15 00:00:00

abstract：:The cardioprotective effect of SUN 1165, a novel sodium channel blocker, was investigated on ischemic myocardium. Nineteen anesthetized dogs were subjected to 2 hours coronary occlusion, and divided into 2 groups. In the control group, physiological saline was infused. In the SUN 1165 group, 2 mg/kg of SUN 1165 was in...

journal_title：Biochemical and biophysical research communications

authors： Sugiyama S,Hanaki Y,Ogawa T,Hieda N,Taki K,Ozawa T

更新日期：1988-12-15 00:00:00

abstract：:Bovine cytochrome c oxidase in 0.1% dodecylmaltoside, 50 mM KCl and 10 mM Tris-HCl, pH 7.4 is monodisperse with an apparent Mr 360,000 (dimer) as estimated by filtration on Ultrogel AcA 34. In the absence of added KCl the apparent Mr is 160,000 (monomer). The dimeric enzyme has a high and a low affinity site for cytoc...

journal_title：Biochemical and biophysical research communications

authors： Nałecz KA,Bolli R,Azzi A

更新日期：1983-07-29 00:00:00

abstract：:Arsenic trioxide (ATO) is remarkably effective for treating acute promyelocytic leukemia. Here, we find that ATO treatment of NB4 and K562 leukemic cells induces activation of ASK1. ASK1 activation was induced most significantly at low concentrations of ATO, where G2/M arrest but not apoptosis was induced. On the othe...

journal_title：Biochemical and biophysical research communications

authors： Yan W,Arai A,Aoki M,Ichijo H,Miura O

更新日期：2007-04-20 00:00:00

abstract：:Atherosclerosis and cancer are the leading causes of mortality around the world that share common pathogenic pathways. The aim of this study is the investigation of the protein profile of atherosclerotic plaque in order to find similar biomarker between cancer and atherosclerosis. The small pieces of human coronary ar...

journal_title：Biochemical and biophysical research communications

authors： Fasehee H,Fakhraee M,Davoudi S,Vali H,Faghihi S

更新日期：2019-02-12 00:00:00

abstract：:The majority of studies on possible roles for collagen hydrolysates in human health have focused on their effects on bone and skin. Hydroxyprolyl-glycine (Hyp-Gly) was recently identified as a novel collagen hydrolysate-derived dipeptide in human blood. However, any possible health benefits of Hyp-Gly remain unclear. ...

journal_title：Biochemical and biophysical research communications

authors： Kitakaze T,Sakamoto T,Kitano T,Inoue N,Sugihara F,Harada N,Yamaji R

更新日期：2016-09-23 00:00:00

abstract：:Hemin (iron protoporphyrin IX) is a necessary component of many proteins, functioning either as a cofactor or an intracellular messenger. Hemoproteins have diverse functions, such as transportation of gases, gas detection, chemical catalysis and electron transfer. Stanniocalcin 1 (STC1) is a protein involved in respir...

journal_title：Biochemical and biophysical research communications

authors： Westberg JA,Jiang J,Andersson LC

更新日期：2011-06-03 00:00:00

abstract：:Binding of phorbol-12,13-dibutyrate (PDBu), a tumor promoter, to quiescent Swiss 3T3 cells increased the number of hexose carriers, resulting in stimulation of membrane transport of 3-O-methylglucose (3MeGlu) in a Ca2+-dependent fashion. Extracellular Ca2+ was necessary to initiate the binding of PDBu to its receptor,...

journal_title：Biochemical and biophysical research communications

authors： Kitagawa K,Nishino H,Iwashima A

更新日期：1985-04-16 00:00:00

abstract：:Adrenomedullin (AM) gains its bioactivity by amidation at its C-terminal, forming "mature AM." The mature AM and the expression of AM receptor component mRNAs, receptor activity-modifying protein 2 and calcitonin receptor-like receptor, from feto-maternal tissues of normal pregnant women and women with histologic chor...

journal_title：Biochemical and biophysical research communications

authors： Makino I,Makino Y,Yoshihara F,Nishikimi T,Kawarabayashi T,Kangawa K,Shibata K

更新日期：2003-02-07 00:00:00

abstract：:Adhesive ascidians have caused serious biofouling problems and huge economic losses in marine ecosystems. However, adhesion mechanisms, particularly on functional proteins involved in ascidian adhesion, remain largely unexplored. Here, we identified 26 representative stolon proteins from the highly invasive fouling as...

journal_title：Biochemical and biophysical research communications

authors： Li S,Huang X,Chen Y,Li X,Zhan A

更新日期：2019-02-26 00:00:00

abstract：:Action potentials of myotubes in culture prepared from 18-19 day -old mouse embryos have a contractile activity and action potentials that are followed by a long lasting after hyperpolarization (ahp) which is blocked by apamin. Myotubes prepared from embryos of mice with muscular dysgenesis (mdg/mdg) did not contract ...

journal_title：Biochemical and biophysical research communications

authors： Romey G,Rieger F,Renaud JF,Pinçon-Raymond M,Lazdunski M

更新日期：1986-05-14 00:00:00

abstract：:Hsp90 and its co-chaperone Cdc37 are required for the activity of numerous eukaryotic protein kinases. c-Jun N-terminal kinases (JNKs) appear to be Hsp90-independent kinases, as their activity is unaffected by Hsp90 inhibition. It is currently unknown why some protein kinases are Hsp90- and Cdc37-dependent for their f...

journal_title：Biochemical and biophysical research communications

authors： Prince T,Matts RL

更新日期：2005-12-23 00:00:00

abstract：:Estrogen induces lordosis through, in part, estrogen receptor (ER)-mediated synthesis of progesterone receptors (PR) in the ventromedial nucleus (VMN). In vitro, PR is activated by the neurotransmitter dopamine through D1-like receptors (1). In vivo, lordosis is induced by dopamine, an effect mediated in part by PR an...

journal_title：Biochemical and biophysical research communications

authors： Zhou D,Apostolakis EM,O'Malley BW

更新日期：1999-12-20 00:00:00

abstract：:Eukaryotic initiation factor 2Bε (eIF2Bε) plays a critical role in the initiation of mRNA translation and its expression and guanine nucleotide exchange activity are major determinants of the rate of protein synthesis. In this work we provide evidence that the catalytic epsilon subunit of eIF2B is subject to ubiquitin...

journal_title：Biochemical and biophysical research communications

authors： Tuckow AP,Kazi AA,Kimball SR,Jefferson LS

更新日期：2013-06-21 00:00:00

abstract：:Vitamin C, or ascorbic acid, decreases paracellular endothelial permeability in a process that requires rearrangement of the actin cytoskeleton. To define the proximal mechanism of this effect, we tested whether it might involve enhanced generation and/or sparing of nitric oxide (NO) by the vitamin. EA.hy926 endotheli...

journal_title：Biochemical and biophysical research communications

authors： May JM,Qu ZC

更新日期：2011-01-14 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic systemic inflammatory disorder of the axial skeleton and shows significant inherited susceptibility. Auto-immune responses have been traditionally considered as a putative pathogenetic event in AS. However, no consistent self-antigen has been identified to responsible for the d...

journal_title：Biochemical and biophysical research communications

authors： Liu J,Zhu P,Peng J,Li K,Du J,Gu J,Ou Y

更新日期：2007-06-01 00:00:00

abstract：:The characteristics of carcinoembryonic antigen (CEA) molecules expressed by different cell types have been examined using cDNA transfection into cells of epithelial, neuroectodermal and hematopoietic origin. Variability in the CEA molecules was observed in terms of monoclonal antibody binding, apparent molecular weig...

journal_title：Biochemical and biophysical research communications

authors： Grimm T,Riethmüller G,Johnson JP

更新日期：1994-11-15 00:00:00

abstract：:Seven monoclonal antibodies to low-density lipoprotein were studied by the ELISA for their reactivity with LDL or VLDL. Cotitration experiments showed that five of them are addressed to different antigenic epitopes. Two of the monoclonal antibodies were temperature independent whereas the others had a decreased bindin...

journal_title：Biochemical and biophysical research communications

authors： Salmon S,Goldstein S,Pastier D,Theron L,Berthelier M,Ayrault-Jarrier M,Dubarry M,Rebourcet R,Pau B

更新日期：1984-12-14 00:00:00

abstract：:Hsc70, the constitutive form of the heat shock protein 70 family of proteins, is involved in a number of biological activities which include protein folding and molecular chaperoning. Previously, we had shown that the immunosuppressant 15-deoxyspergualin (DSG) specifically interacted with Hsc70, as well as the Hsp90 f...

journal_title：Biochemical and biophysical research communications

authors： Nadler SG,Dischino DD,Malacko AR,Cleaveland JS,Fujihara SM,Marquardt H

更新日期：1998-12-09 00:00:00

abstract：:To investigate the mechanism underlying the antiatherogenic effect of estrogen, we examined the role of estrogen in the regulation of endothelin-1 (ET-1) production by cultured bovine carotid arterial endothelial cells. Treatment of the cells with 17beta-estradiol dose dependently inhibited gene expression and peptide...

journal_title：Biochemical and biophysical research communications

authors： Akishita M,Kozaki K,Eto M,Yoshizumi M,Ishikawa M,Toba K,Orimo H,Ouchi Y

更新日期：1998-10-09 00:00:00

abstract：:Laminins, the major basement membrane glycoproteins, are composed of three subunits. We identified a splice variant of the human laminin alpha4 subunit transcript containing 21 extra nucleotides. A heptapeptide sequence, MDCPTIS, was inserted close to the two cysteine residues possibly involved in the intersubunit dis...

journal_title：Biochemical and biophysical research communications

authors： Hayashi Y,Kim KH,Fujiwara H,Shimono C,Yamashita M,Sanzen N,Futaki S,Sekiguchi K

更新日期：2002-12-06 00:00:00

abstract：:Copper is a micronutrient that is required for proper metabolic functioning of most prokaryotic and eukaryotic organisms. To sustain an adequate supply of copper, a cell requires molecular mechanisms that control the metal content to avoid copper toxicity. This toxicity comes primarily from the reactivity of copper, w...

journal_title：Biochemical and biophysical research communications

authors： Latorre M,Olivares F,Reyes-Jara A,López G,González M

更新日期：2011-03-25 00:00:00

abstract：:HES-3 is a cerebellar Purkinje cell-specific helix-loop-helix factor structurally related to the products of the Drosophila hairy and Enhancer of split genes. Here, we report the nucleotide sequence and chromosomal locus of the mouse Hes-3 gene. This gene consists of four exons and the exon-intron boundaries are well ...

journal_title：Biochemical and biophysical research communications

authors： Sakagami T,Sakurada K,Sakai Y,Watanabe T,Nakanishi S,Kageyama R

更新日期：1994-08-30 00:00:00

abstract：:We previously showed that NDP52 (also known as calcoco2) plays a role as an autophagic receptor for phosphorylated tau facilitating its clearance via autophagy. Here, we examined the expression and association of NDP52 with autophagy-regulated gene (ATG) proteins including LC3, as well as phosphorylated tau and amyloi...

journal_title：Biochemical and biophysical research communications

authors： Kim S,Lee D,Song JC,Cho SJ,Yun SM,Koh YH,Song J,Johnson GV,Jo C

更新日期：2014-11-07 00:00:00