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Identification of disease-associated proteins by proteomic approach in ankylosing spondylitis.

Abstract：

:Ankylosing spondylitis (AS) is a chronic systemic inflammatory disorder of the axial skeleton and shows significant inherited susceptibility. Auto-immune responses have been traditionally considered as a putative pathogenetic event in AS. However, no consistent self-antigen has been identified to responsible for the disorders in AS to this day. In this study, serum protein profiles of AS patients and healthy controls from a large Chinese AS family were investigated by two dimensional electrophoresis analysis. A group of four highly expressed protein spots was observed in all AS patients' profiles and subsequently identified as isoforms of haptoglobin precursor (pre-Hp) by ESI-Q-TOF MS/MS. Increased expression of haptoglobin precursor were also observed in sera of sporadic AS patients. Moreover, bioinformatics analysis revealed epitopes derived from haptoglobin precursor with high affinity binding to HLA-B( *)2705, a primary subtype associated with AS. These results indicate that pre-Hp may be involved in the pathogenesis of AS.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Liu J,Zhu P,Peng J,Li K,Du J,Gu J,Ou Y

doi

10.1016/j.bbrc.2007.03.179

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

531-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)00683-3

journal_volume

357

pub_type

杂志文章

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