Abstract:
:Tuberculosis and HIV continue to be the world-leading killers among infectious diseases, primarily affecting poor people in many developing countries. Despite differences in the immunopathogenesis of human infection with tuberculosis and HIV, experimental evidence from clinical studies and relevant animal models can be used to reflect on the cellular mechanisms responsible for an increased risk of active tuberculosis among HIV-infected individuals. In this review, we will discuss the molecular features and regulation of cytolytic T cells and how deficient cytolytic T cell responses contribute to the pathogenesis of TB and HIV infection as well as TB/HIV co-infection.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Brighenti S,Andersson Jdoi
10.1016/j.bbrc.2010.02.141subject
Has Abstractpub_date
2010-05-21 00:00:00pages
50-7issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(10)00375-Xjournal_volume
396pub_type
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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