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Control of fungal sterol C-24 transalkylation: importance to developmental regulation.

Abstract：

:When cultures of Gibberella fujikuroi are incubated with 24-epiiminolanosterol the introduction of a methyl group into sterol side chains at C-24 is blocked inducing a mycelial accumulation of lanosterol and 24-desalkylsterols, i.e., having the cholestane side chain. The altered sterol composition lead to aberrant mycelial membranes resulting in growth inhibition. A compensatory physiological response to the ensuing hyphal death was induction of asexual sporulation. The results are interpreted to imply that regulation of sterol C-24 transalkylation may be a mechanism to mediate life cycle events of fungi.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nes WD,Hanners PK,Parish EJ

doi

10.1016/s0006-291x(86)80006-7

subject

Has Abstract

pub_date

1986-09-14 00:00:00

pages

410-5

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(86)80006-7

journal_volume

139

pub_type

杂志文章

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