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The mechanism of antifungal action of (S)-2-amino-4-oxo-5-hydroxypentanoic acid, RI-331: the inhibition of homoserine dehydrogenase in Saccharomyces cerevisiae.

Abstract：

:We have explored the mechanism by which an antifungal antibiotic, (S)-2-amino-4-oxo-5-hydroxypentanoic acid, RI-331, preferentially inhibits protein biosynthesis in Saccharomyces cerevisiae, by inhibiting the biosynthesis of the aspartate family of amino acids, methionine, isoleucine and threonine. This inhibition was effected by inhibiting the biosynthesis of their common intermediate precursor homoserine. The target enzyme of RI-331 was homoserine dehydrogenase (EC.1.1.1.3) which is involved in converting aspartate semialdehyde to homoserine in the pathway from aspartate to homoserine. The enzyme is lacking in animals. So the antibiotic is selectively toxic to prototrophic fungi.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamaki H,Yamaguchi M,Imamura H,Suzuki H,Nishimura T,Saito H,Yamaguchi H

doi

10.1016/0006-291x(90)92397-i

subject

Has Abstract

pub_date

1990-04-30 00:00:00

pages

837-43

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)92397-I

journal_volume

168

pub_type

杂志文章

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