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Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP).

Abstract：

:Using PAGE--Autoradioblotting technique we have characterized an E--FABP in human epidermal cells that is distinct from liver-, heart-, intestine- and adipose tissue-FABPs. FABP radiobinding analysis was performed directly on protein extracts without prior partial purification. E-FABP has a Mr of approximately 15 kDa and binds oleic acid with high affinity but does not bind all-trans-, 13-cis- and 9-cis-retinoic acid nor all-trans-retinol. Expression levels of E-FABP were low in normal epidermis, higher in human cultured keratinocytes and still higher in psoriasis, a disease characterized by abnormal epidermal differentiation. These findings suggest that epidermal cells may have a distinct fatty acid metabolism compared to other tissues.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Siegenthaler G,Hotz R,Chatellard-Gruaz D,Jaconi S,Saurat JH

doi

10.1006/bbrc.1993.1073

subject

Has Abstract

pub_date

1993-01-29 00:00:00

pages

482-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X83710739

journal_volume

190

pub_type

杂志文章

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