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Extracellular ATP elevates intracellular free calcium in rat parotid acinar cells.

Abstract：

:The effect of extracellular ATP on intracellular free Ca2+ was characterized in quin2-loaded parotid acinar cells. ATP specifically increased the intracellular Ca2+ concentration six-fold above a basal level of 180 nM. Of other purine nucleotides tested, only adenylylthiodiphosphate (ATP gamma S) had significant activity. ATP and the muscarinic agonist carbachol increased intracellular Ca2+ even in the absence of extracellular Ca2+. Both agonists stimulated K+ release, which was followed by reuptake of K+, even in the continued presence of agonist. In the absence of Mg2+, ATP was much more potent but no more efficacious in elevating intracellular Ca2+, suggesting that ATP4- is the active species. The effect of ATP was reversed by removal with hexokinase, arguing against a role for an active contaminant of ATP and against a non-specific permeabilizing effect of extracellular ATP. Lactate dehydrogenase release was unaffected by a maximally effective concentration of ATP. These observations are consistent with a possible neurotransmitter role for ATP in the rat parotid gland.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

McMillian MK,Soltoff SP,Cantley LC,Talamo BR

doi

10.1016/0006-291x(87)90399-8

subject

Has Abstract

pub_date

1987-12-16 00:00:00

pages

523-30

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90399-8

journal_volume

149

pub_type

杂志文章

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