Trim11 increases expression of dopamine beta-hydroxylase gene by interacting with Phox2b.

abstract：:Molecular chaperones prevent the aggregation of partially folded or misfolded forms of protein. alpha-crystallin performs such a function in the ocular lens. To gain insight into the mechanism of the anti-aggregation activity of alpha-crystallin, we performed dynamic light scattering (DLS) measurements investigating i...

journal_title：Biochemical and biophysical research communications

authors： Bettelheim FA,Ansari R,Cheng QF,Zigler JS Jr

更新日期：1999-08-02 00:00:00

abstract：:Angiogenesis is critical to a wide range of physiological and pathological processes. Scutellarin, a major flavonoid of a Chinese herbal medicine Erigeron breviscapus (Vant.) Hand. Mazz. has been shown to offer beneficial effects on cardiovascular and cerebrovascular functions. However, scutellarin's effects on angiog...

journal_title：Biochemical and biophysical research communications

authors： Gao ZX,Huang DY,Li HX,Zhang LN,Lv YH,Cui HD,Zheng JH

更新日期：2010-09-10 00:00:00

abstract：:Low molecular weight-PTP has been reported as a redox-sensitive protein during both platelet-derived growth factor and integrin signalling. In response to oxidation the phosphatase undergoes a reversible inactivation, which in turn leads to the increase in tyrosine phosphorylation of its substrates and the properly ex...

journal_title：Biochemical and biophysical research communications

authors： Giannoni E,Raugei G,Chiarugi P,Ramponi G

更新日期：2006-09-22 00:00:00

abstract：:The gene located upstream of the nlp gene at min 69 on the chromosome of Escherichia coli was cloned from the plasmid pLC7-42 constructed by Clarke and Carbon. The extract of the strain harboring the plasmid containing this gene showed increased activity of the prenyltransferase. The product of the enzyme reaction was...

journal_title：Biochemical and biophysical research communications

authors： Asai K,Fujisaki S,Nishimura Y,Nishino T,Okada K,Nakagawa T,Kawamukai M,Matsuda H

更新日期：1994-07-15 00:00:00

abstract：:We examined the expression of P-glycoprotein in human placentas and hydatidiform moles. Trophoblasts in all the examined placentas and moles expressed P-glycoprotein, and the size of the P-glycoprotein was smaller than that in multidrug-resistant human epidermoid carcinoma KB cells. The P-glycoprotein in the placenta ...

journal_title：Biochemical and biophysical research communications

authors： Nakamura Y,Ikeda S,Furukawa T,Sumizawa T,Tani A,Akiyama S,Nagata Y

更新日期：1997-06-27 00:00:00

abstract：:Members of the armadillo (arm) repeat family of proteins are implicated in tumorigenesis, embryonic development, and maintenance of tissue integrity. We have cloned cDNA for a novel human arm repeat protein, ALEX1, encoding 453 amino acids. ALEX1 shares significant homology with uncharacterized ORF KIAA0512 and putati...

journal_title：Biochemical and biophysical research communications

authors： Kurochkin IV,Yonemitsu N,Funahashi SI,Nomura H

更新日期：2001-01-12 00:00:00

abstract：:Intracellular B(12) metabolism involves a B(12) trafficking chaperone CblC that is well conserved in mammals including human. The protein CblC is known to bind cyanocobalamin (CNCbl, vitamin B(12)) inducing the base-off transition and convert it into an intermediate that can be used in enzyme cofactor synthesis. The b...

journal_title：Biochemical and biophysical research communications

authors： Jeong J,Kim J

更新日期：2011-08-26 00:00:00

abstract：:A rat liver-specific antigen (RLSA) lost its binding ability to the corresponding monoclonal antibody after treatment with N-glycanase or sialidase, which suggested that the specific binding site might be in a portion of the sugar chain containing sialic acid. The specific antigen reacted with wheat germ agglutinin, l...

journal_title：Biochemical and biophysical research communications

authors： Sato K,Ikeda T,Osada Y

更新日期：1988-05-16 00:00:00

abstract：:The major active protein phosphatase present in a rabbit skeletal muscle extract is associated with the glycogen particle and migrates in sucrose density gradient centrifugation as a Mr = 70,000 protein and contains modulator activity. Addition of extra modulator protein causes a time- and concentration-dependent conv...

journal_title：Biochemical and biophysical research communications

authors： Vandenheede JR,Yang SD,Merlevede W

更新日期：1983-09-30 00:00:00

abstract：:In the case of a new viral disease outbreak, an immediate development of virus detection kits and vaccines is required. For COVID-19, we established a rapid production procedure for SARS-CoV-2 spike protein (S protein) by using the baculovirus-silkworm expression system. The baculovirus vector-derived S proteins were ...

journal_title：Biochemical and biophysical research communications

authors： Fujita R,Hino M,Ebihara T,Nagasato T,Masuda A,Lee JM,Fujii T,Mon H,Kakino K,Nagai R,Tanaka M,Tonooka Y,Moriyama T,Kusakabe T

更新日期：2020-08-20 00:00:00

abstract：:Eukaryotic gene regulation is closely correlated with histone covalent modifications. Recently, histone H2B lysine-123 (H2B-K123) ubiquitination has been implicated in regulation of transcription as well as histone H3 lysine-4 (H3-K4) methylation which is further associated with active transcription. However, whether ...

journal_title：Biochemical and biophysical research communications

authors： Shukla A,Bhaumik SR

更新日期：2007-07-27 00:00:00

abstract：:The isolated oesophagus of Lymnaea stagnalis was used as a bioassay preparation to identify peptides that modulate the activity of the oesophagus. Several modulatory messengers were detected from the oesophageal extract. One of these, having an excitatory action, was further purified from both the oesophagus and the c...

journal_title：Biochemical and biophysical research communications

authors： Li KW,Holling T,de With ND,Geraerts WP

更新日期：1993-12-30 00:00:00

abstract：:The present study was designed to clarify the cellular localization and expression of leptin receptor(s) [OB-R(s)] mRNA including its splice variants and their correlation with the cells which secrete placental hormone, placental lactogen-II (PL-II), in rat placentae. By in situ hybridization analysis, hybridization s...

journal_title：Biochemical and biophysical research communications

authors： Kawai M,Murakami T,Otani S,Shima K,Yamaguchi M,Kishi K

更新日期：1999-04-13 00:00:00

abstract：:Multidrug resistance protein 4 (MRP4) is a member of subfamily C of the ATP-binding cassette superfamily of membrane transport proteins. MRP4 mediates the ATP-dependent efflux of many endogenous and exogenous solutes across the plasma membrane, and in polarized cells, it localizes to the apical or basolateral plasma m...

journal_title：Biochemical and biophysical research communications

authors： Miah MF,Conseil G,Cole SP

更新日期：2016-01-22 00:00:00

abstract：:Structural studies using 500 MHz 1H NMR spectroscopy on Bam H1 recognition site d(GGATCC)2 in solution at 19 degrees is reported. The resonances from the sugar ring and base protons have been assigned from the 2D-COSY and NOESY spectra. Analyses of the NOESY cross-peaks between the base protons H8/H6 and sugar protons...

journal_title：Biochemical and biophysical research communications

authors： Sarma MH,Dhingra MM,Gupta G,Sarma RH

更新日期：1985-08-30 00:00:00

abstract：:Using baculoviral and bacterial systems, we expressed biologically active recombinant rat IL-13 and generated neutralizing rat IL-13 antiserum. Recombinant rat IL-13 produced by baculovirus-infected insect cells stimulated proliferation of TF-1 premyeloid cell line and induced expression of 15-lipoxygenase mRNA in hum...

journal_title：Biochemical and biophysical research communications

authors： Lakkis FG,Cruet EN,Nassar GM,Badr KF,Pascual DW

更新日期：1997-06-27 00:00:00

abstract：:The marked impairment of hepatic drug metabolism during inflammation and infections has been known for many years and shown to result from down-regulation of cytochrome P450s (CYP) by cytokines. However, the mechanism of this repression is unknown. Using primary cultures of human hepatocytes, we show here that interle...

journal_title：Biochemical and biophysical research communications

authors： Pascussi JM,Gerbal-Chaloin S,Pichard-Garcia L,Daujat M,Fabre JM,Maurel P,Vilarem MJ

更新日期：2000-08-11 00:00:00

abstract：:E Prostanoid (EP) receptors play an important role in urinary Na(+) excretion. In the kidney, the epithelial sodium channel (ENaC) is the rate-limiting-step for Na(+) reabsorption. We hypothesized that activation of EP1/EP3 regulates the expression of ENaC in the face of renin-angiotensin-aldosterone-system (RAAS) act...

journal_title：Biochemical and biophysical research communications

authors： González AA,Céspedes C,Villanueva S,Michea L,Vio CP

更新日期：2009-11-13 00:00:00

abstract：:The PKC alpha, beta, delta, epsilon and zeta isoenzyme changes in the rat kidney cortex have been investigated after temporary occlusion of the renal artery, followed by reperfusion for up to 4 h. Increased PKC alpha, delta and epsilon immunoreactivity and PKC alpha activity occurred within 60 min of postischemic refl...

journal_title：Biochemical and biophysical research communications

authors： La Porta CA,Comolli R

更新日期：1993-03-31 00:00:00

abstract：:Adhesive ascidians have caused serious biofouling problems and huge economic losses in marine ecosystems. However, adhesion mechanisms, particularly on functional proteins involved in ascidian adhesion, remain largely unexplored. Here, we identified 26 representative stolon proteins from the highly invasive fouling as...

journal_title：Biochemical and biophysical research communications

authors： Li S,Huang X,Chen Y,Li X,Zhan A

更新日期：2019-02-26 00:00:00

abstract：:We present here the biosynthesis of AgNps from the aqueous extract of H. thebaica fruit, and monitored through UV-Vis spectrophotometer. The functional group were characterized through ATR-FTIR spectroscopy, the particle size, morphologies and elemental composition of the nanoparticles were investigated by using TEM, ...

journal_title：Biochemical and biophysical research communications

authors： Bello BA,Khan SA,Khan JA,Syed FQ,Mirza MB,Shah L,Khan SB

更新日期：2017-08-26 00:00:00

abstract：:Circulating hormones are engaged in initiating and controlling the process of spermatogenesis, however, the Sertoli cell tight junctions prevent these substances from directly influencing the spermatogenic cells. Thus, the Sertoli cells play a vital role in regulating the spermatogenic process. Our studies correlate r...

journal_title：Biochemical and biophysical research communications

authors： Page KC,Heitzman DA,Chernin MI

更新日期：1996-05-15 00:00:00

abstract：:Myozyme is a recombinant human acid alpha-glucosidase (rhGAA) that is currently the only drug approved for treating Pompe disease, and its low efficacy means that a high dose is required. Mannose-6-phosphate (M6P) glycosylation on rhGAA is a key factor influencing lysosomal enzyme targeting and the efficacy of enzyme ...

journal_title：Biochemical and biophysical research communications

authors： Park H,Kim J,Lee YK,Kim W,You SK,Do J,Jang Y,Oh DB,Il Kim J,Kim HH

更新日期：2018-01-22 00:00:00

abstract：:The immunoproteasome is a multicatalytic protease complex in all eukaryotic cells, which plays a key role in regulating essential cellular processes. However, the role of immunoproteasome subunit β2i in regulation of cardiac fibrosis and inflammation in deoxycorticosterone-acetate (DOCA)/salt mice remains unknown. Wil...

journal_title：Biochemical and biophysical research communications

authors： Yan W,Bi HL,Liu LX,Li NN,Liu Y,Du J,Wang HX,Li HH

更新日期：2017-08-19 00:00:00

abstract：:Systemic administration of 3-nitropropionic acid (3-NP) facilitates the development of select striatal lesions, and some reports provide clues about this pathology. In this study, we investigated the relationship between reduced levels of brain-derived neurotrophic factor (BDNF) in lesioned brain regions and caspase a...

journal_title：Biochemical and biophysical research communications

authors： Cho KJ,Kim GW

更新日期：2015-09-25 00:00:00

abstract：:Cell motility and cell stiffness are closely related to metastatic activity of cancer cells. (-)-Epigallocatechin gallate (EGCG) has been shown to inhibit spontaneous metastasis of melanoma cell line into the lungs of mice, so we studied the effects of EGCG on cell motility, cell stiffness, and expression of vimentin ...

journal_title：Biochemical and biophysical research communications

authors： Takahashi A,Watanabe T,Mondal A,Suzuki K,Kurusu-Kanno M,Li Z,Yamazaki T,Fujiki H,Suganuma M

更新日期：2014-01-03 00:00:00

abstract：:A novel iron-binding protein from rat liver homogenates was purified 1,800-fold with a 5.7% yield, to apparent homogeneity. The molecular weight of the protein was estimated to be 16,000, by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. The purified protein exhibited 0.43 mol of iron bi...

journal_title：Biochemical and biophysical research communications

authors： Furukawa T,Taketani S,Kohno H,Tokunaga R

更新日期：1991-11-27 00:00:00

abstract：:Human epidermal melanocytes and keratinocytes express mRNA for all enzymes involved in de novo synthesis/recycling of the cofactor (6R) L-erythro 5,6,7,8 tetrahydrobiopterin (6BH4) in normal healthy individuals. An enhanced epidermal de novo synthesis was identified in association with decreased epidermal phenylalanin...

journal_title：Biochemical and biophysical research communications

authors： Schallreuter KU,Zschiesche M,Moore J,Panske A,Hibberts NA,Herrmann FH,Metelmann HR,Sawatzki J

更新日期：1998-02-13 00:00:00

abstract：:Thyroid cells transformed by the Kirsten-ras oncogene become tumorigenic in syngeneic animals. Their growth is no longer dependent on TSH but becomes dependent on serum. Combining morphological and biochemical evidence, we show that serum withdrawal induces apoptotic cell death in Kirsten and Harvey-ras transformed th...

journal_title：Biochemical and biophysical research communications

authors： di Jeso B,Ulianich L,Racioppi L,D'Armiento F,Feliciello A,Pacifico F,Consiglio E,Formisano S

更新日期：1995-09-25 00:00:00

abstract：:Recent studies have suggested that astrocytes release gliotransmitters (i.e., ATP, L-glutamate, D-serine, and peptide hormones) and participate actively in synaptic functioning. Although ATP release from astrocytes modulates the activity of neurons, the mechanisms regulating the ATP release from astrocytes and the sou...

journal_title：Biochemical and biophysical research communications

authors： Oya M,Kitaguchi T,Yanagihara Y,Numano R,Kakeyama M,Ikematsu K,Tsuboi T

更新日期：2013-08-16 00:00:00