当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > E Prostanoid-1 receptor regulates renal medullary alphaENaC in rats infused with angiotensin II.

E Prostanoid-1 receptor regulates renal medullary alphaENaC in rats infused with angiotensin II.

Abstract：

:E Prostanoid (EP) receptors play an important role in urinary Na(+) excretion. In the kidney, the epithelial sodium channel (ENaC) is the rate-limiting-step for Na(+) reabsorption. We hypothesized that activation of EP1/EP3 regulates the expression of ENaC in the face of renin-angiotensin-aldosterone-system (RAAS) activation. In primary cultures of inner medullary collecting duct (IMCD) cells, sulprostone (EP1>EP3 agonist, 1 microM) and 17 Phenyl trinor (17 Pt, EP1 agonist, 10 microM) prevented the up-regulation of alphaENaC mRNA induced by aldosterone (10 nM). In Sprague-Dawley rats infused with angiotensin II (0.4 microg/kg/min), alphaENaC expression was up-regulated in renal cortex and medulla coincidently with high plasma aldosterone levels. Sulprostone and/or 17 Pt prevented this effect in renal medulla but not in cortex. Immunocytochemistry demonstrated that IMCD cells express EP1. Our results suggest that specific activation of EP1 receptor during RAAS activation antagonizes the action of aldosterone on alphaENaC expression in the renal medulla.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

González AA,Céspedes C,Villanueva S,Michea L,Vio CP

doi

10.1016/j.bbrc.2009.08.157

subject

Has Abstract

pub_date

2009-11-13 00:00:00

pages

372-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01764-1

journal_volume

389

pub_type

杂志文章

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