Regulation of 1,25(OH)2 vitamin D3 receptor content in cultured LLC-PK1 kidney cells limits hormonal responsiveness.

abstract：BACKGROUND:Cisplatin-induced ototoxicity affects a high percentage of new cancer patients worldwide. The detailed mechanism of cisplatin-induced ototoxicity is not completely understood. We investigated whether rapamycin could protect rats from cisplatin-induced ototoxicity. METHODS:Forty-eight male Wistar rats were r...

journal_title：Biochemical and biophysical research communications

authors： Fang B,Xiao H

更新日期：2014-06-13 00:00:00

abstract：:Oxidative stress plays an important role in the development of diabetic retinopathy. Here, we examined whether α-lipoic acid (α-LA), a natural antioxidant, attenuated retinal injury in diabetic mice. The α-LA was orally administered to control mice or mice with streptozotocin-induced diabetes. We found that α-LA reduc...

journal_title：Biochemical and biophysical research communications

authors： Kim YS,Kim M,Choi MY,Lee DH,Roh GS,Kim HJ,Kang SS,Cho GJ,Hong EK,Choi WS

更新日期：2018-09-10 00:00:00

abstract：:Long-term neuropathic pain can lead to anxiety, depression, and other issues, which seriously affect patients' quality of life. For this reason, it is important to find effective treatments. Studies have shown that glial cell-derived neurotrophic factor (GDNF) can relieve neuropathic pain. However, its mechanism of ac...

journal_title：Biochemical and biophysical research communications

authors： Pan Y,Jiang L,Wang C

更新日期：2020-02-05 00:00:00

abstract：:Photoinactivation is a common phenomenon in bioluminescence ctenophore photoproteins (e.g mnemiopsin, berovin and BfosPP) with still unknown mechanism. The activity of coelenterate photoproteins (e.g aequorin), which has high structural similarity with ctenophore photoproteins, is not affected by light. Recently, we h...

journal_title：Biochemical and biophysical research communications

authors： Pashandi Z,Molakarimi M,Mohseni A,Sajedi RH,Taghdir M,Naderi-Manesh H

更新日期：2017-08-19 00:00:00

abstract：:The present study provides the first evidence that nitropolycyclic aromatic hydrocarbons such as 1-nitropyrene and 2-nitrofluorene are metabolized to the corresponding formylamino compounds in animal bodies. The study shows that the formation of such novel metabolites, 1-formylaminopyrene and 2-formylaminofluorene, is...

journal_title：Biochemical and biophysical research communications

authors： Tatsumi K,Amano H

更新日期：1987-01-30 00:00:00

abstract：:Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machi...

journal_title：Biochemical and biophysical research communications

authors： Homma T,Shimizu M,Kuroda R

更新日期：2011-01-07 00:00:00

abstract：:We investigated the serial expression of c-myc oncogene during differentiation of normal human burst-forming unit, erythroid (BFU-E), in vitro, together with the replating efficiency and the expression of transferrin receptors. We found that the c-myc oncogene was expressed in the early progeny of BFU-E and that this ...

journal_title：Biochemical and biophysical research communications

authors： Umemura T,Umene K,Nishimura J,Fukumaki Y,Sakaki Y,Ibayashi H

更新日期：1986-03-13 00:00:00

abstract：:There is increasing evidence that a functional interaction exists between interleukin-1beta (IL-1beta) and N-methyl-D-aspartate (NMDA) receptors. The present study attempted to elucidate the effect of IL-1beta on the NMDA-induced outward currents in mechanically dissociated hippocampal neurons using a perforated patch...

journal_title：Biochemical and biophysical research communications

authors： Zhang R,Yamada J,Hayashi Y,Wu Z,Koyama S,Nakanishi H

更新日期：2008-08-08 00:00:00

abstract：:Calcium regulates diverse cellular activities in plants through the action of calmodulin (CaM). By using (35)S-labeled CaM to screen an Arabidopsis seedling cDNA expression library, a cDNA designated as AtCh-CPN10 (Arabidopsis thaliana chloroplast chaperonin 10) was cloned. Chloroplast CPN10, a nuclear-encoded protein...

journal_title：Biochemical and biophysical research communications

authors： Yang T,Poovaiah BW

更新日期：2000-08-28 00:00:00

abstract：:The effects of the small noncatalytic subunit of myosin light chain phosphatase (MLCPsr) on the Ca2+-induced contraction of smooth muscle were investigated in the Triton X-100-permeabilized porcine renal artery. The full-length recombinant chicken MLCPsr obtained by the bacterial expression system induced an additiona...

journal_title：Biochemical and biophysical research communications

authors： Zhou Y,Nishimura J,Hirano K,Kanaide H

更新日期：1999-01-08 00:00:00

abstract：:Pain is a common symptom of injuries and inflammatory-related conditions. The perception of pain, commonly known as nociception, depends on integrated receptors and molecular pathways. Inflammatory mediators are involved in the genesis, persistence, and severity of pain. Noxious stimuli can trigger a cascade of inflam...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2007-02-09 00:00:00

abstract：:Proton release from HeLa cells is stimulated by external oxidants for the transplasmalemma electron transport enzymes. These oxidants, such as ferricyanide and diferric transferrin, also stimulate cell growth. We now present evidence that proton release associated with the reduction of ferricyanide and diferric transf...

journal_title：Biochemical and biophysical research communications

authors： Sun IL,Garcia-Cañero R,Liu W,Toole-Simms W,Crane FL,Morré DJ,Löw H

更新日期：1987-05-29 00:00:00

abstract：:Fragments of the human glutathione S-transferase pi gene and 15 kb of its 5' flanking region have been fused to the chloramphenicol acetyl transferase (CAT) reporter gene. Transfection into a number of human cell lines (Hela, HepG2, MCF7 and EJ) has demonstrated that the AP1 binding site, located between nucleotides -...

journal_title：Biochemical and biophysical research communications

authors： Xia CL,Cowell IG,Dixon KH,Pemble SE,Ketterer B,Taylor JB

更新日期：1991-04-15 00:00:00

abstract：:The glycoprotein processing inhibitors bromoconduritol and N-methyl-1-deoxynojirimycin inhibit myoblast fusion and differentiation, suggesting the critical involvement of one or more glycoproteins in the control of skeletal myogenesis. In the present study we have examined the effect of inhibitors of glycoprotein proc...

journal_title：Biochemical and biophysical research communications

authors： Trudel GC,Holland PC

更新日期：1992-04-15 00:00:00

abstract：AIM:AF1q has a precise oncogenic function. The purpose of this study is to investigate whether CBD has an effect on the AF1q/ICAM-1 regulatory axis in Burkitt's lymphoma (BL), and thus has potential to enhance immunotherapy and reduce side effects. METHODS:We established BL cell lines with altered AF1q expression usin...

journal_title：Biochemical and biophysical research communications

authors： Togano T,Kim N,Kim N,Park GS,Park AK,Bennet M,Park J

更新日期：2019-11-26 00:00:00

abstract：:BHLHB2/DEC1 is a transcription factor implicated in cell proliferation, apoptosis, and metabolism, and is also known to play an important role in the regulation of the mammalian circadian rhythm. However, its precise role in metabolism remains unclear. We investigated the link between BHLHB2 and ChREBP, a glucose-acti...

journal_title：Biochemical and biophysical research communications

authors： Iizuka K,Horikawa Y

更新日期：2008-09-12 00:00:00

abstract：:Protein, mRNA and activity levels of the calcium-independent protein kinase C (nPKC) isoenzymes were examined in NG108-15 cells. Western blot analyses reveal that proliferating NG 108-15 cells express the delta, epsilon, and eta, but not the theta species. The atypical species PKC zeta was also detected. Differentiati...

journal_title：Biochemical and biophysical research communications

authors： Battaini F,Pascale A,Lucchi L,Racchi M,Bergamaschi S,Parenti M,Wetsel WC,Govoni S,Trabucchi M

更新日期：1994-09-30 00:00:00

abstract：:Numerous epidemiological data indicate that vitamin D receptor (VDR) signaling induced by its ligand or active metabolite 1α,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)) has anti-cancer activity in several colon cancers. 1α,25(OH)(2)D(3) induces the epithelial differentiation of SW480 colon cancer cells expressing VDR ...

journal_title：Biochemical and biophysical research communications

authors： Kouchi Z,Fujiwara Y,Yamaguchi H,Nakamura Y,Fukami K

更新日期：2011-05-20 00:00:00

abstract：:Acinetobacter lwoffii K24 known as an aniline degrading bacterium has also been found to utilize p-hydroxybenzoate as a sole carbon source. In this study, 2-DE using Q-Sepharose column separation was attempted for fast screening of protocatechuate 3,4-dioxygenase for catabolism of p-hydroxybenzoate in A. lwoffii K24. ...

journal_title：Biochemical and biophysical research communications

authors： Kahng HY,Cho K,Song SY,Kim SJ,Leem SH,Kim SI

更新日期：2002-07-26 00:00:00

abstract：:NGA is a human melanoma-associated antigen recognized by a panel of murine monoclonal antibodies developed in this laboratory. NGA consists of a 23.5 kDa core protein which is glycosylated in vivo to give a family of glycoproteins (30-60 kDa). Treatment of human melanoma G361 cells with the phorbol ester PMA resulted ...

journal_title：Biochemical and biophysical research communications

authors： Feyles V,Dixon WT,Sikora LK,Jerry LM

更新日期：1989-02-15 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) Tax-induced activation of nuclear factor-kappaB (NFkappaB) is thought to play a critical role in T-cell transformation and onset of adult T-cell leukemia. However, the molecular mechanism of the Tax-induced NFkappaB activation remains unknown. One of the mitogen-activated pr...

journal_title：Biochemical and biophysical research communications

authors： Gohda J,Irisawa M,Tanaka Y,Sato S,Ohtani K,Fujisawa J,Inoue J

更新日期：2007-05-25 00:00:00

abstract：:Apoaequorin was targeted to the cytosol, nucleus, and endoplasmic reticulum of HeLa cells in order to determine the effect of Ca(2+) release from the ER on protein degradation. In resting cells apoaequorin had a rapid half-life (ca. 20-30 min) in the cytosol or nucleus, but was relatively stable for up to 24 h in the ...

journal_title：Biochemical and biophysical research communications

authors： Jeffery J,Kendall JM,Campbell AK

更新日期：2000-02-24 00:00:00

abstract：:Reactive oxygen species such as hydrogen peroxide (H(2)O(2)) have taken center stage as bona fide second messengers in various signaling pathways. Here, we report the synthesis, metabolic fate, and effectiveness in modulating such pathways of a Tat-catalase conjugate. Incubation of L2 cells with Tat-catalase greatly i...

journal_title：Biochemical and biophysical research communications

authors： Watanabe N,Iwamoto T,Bowen KD,Dickinson DA,Torres M,Forman HJ

更新日期：2003-03-28 00:00:00

abstract：:Interleukin-18 (IL-18) is a proinflammatory cytokine. This protein has a role in regulating immune responses and exhibits significant anti-tumor activities. Epidermal growth factor (EGF) is an important growth factor that plays a central role in the regulation of cell cycle and differentiation. It was proposed that a ...

journal_title：Biochemical and biophysical research communications

authors： Lu JX,Peng Y,Meng ZF,Jin LQ,Lu YS,Guan MX

更新日期：2005-08-19 00:00:00

abstract：:Permeability alteration of microvascular endothelia is a factor in the plasma leakage produced by dengue virus (DV) infection, and beta3 integrin plays central roles in maintaining capillary integrity and regulating vascular permeability. In this study, interaction between beta3 integrin and DV serotype 2 (DV2) was in...

journal_title：Biochemical and biophysical research communications

authors： Zhang JL,Wang JL,Gao N,Chen ZT,Tian YP,An J

更新日期：2007-05-11 00:00:00

abstract：:Simultaneous incubation of bovine adrenal medullary plasma membranes (PM) with chromaffin granules (CG) resulted in the release of the soluble granular content. The molecular mechanism of this process was studied with several monoclonal antibodies (mAb) raised against different plasma membrane components. Specific inh...

journal_title：Biochemical and biophysical research communications

authors： Bohner K,Boons J,Gheuens J,Konings F,De Potter WP

更新日期：1985-12-31 00:00:00

abstract：:Peroxynitrite-mediated oxidation of ferrous nitrosylated myoglobin (Mb(II)-NO) involves the transient ferric nitrosylated species (Mb(III)-NO), followed by ()NO dissociation and formation of ferric myoglobin (Mb(III)). In contrast, peroxynitrite-mediated oxidation of ferrous oxygenated myoglobin (Mb(II)-O2) involves t...

journal_title：Biochemical and biophysical research communications

authors： Ascenzi P,Ciaccio C,Coletta M

更新日期：2007-11-30 00:00:00

abstract：:Coordinated migration of endothelial cells models the remodeling of existing endothelia as well as angiogenesis and vasculogenesis. Platelet-endothelial cell adhesion molecule-1, PECAM-1, a transmembrane endothelial adhesion protein, binds and activates the tyrosine phosphatase SHP-2 via phosphotyrosines 663 and 686. ...

journal_title：Biochemical and biophysical research communications

authors： Gratzinger D,Barreuther M,Madri JA

更新日期：2003-01-31 00:00:00

abstract：:Diabetes mellitus (DM) is a risk factor for abnormal heart development, but the molecular mechanism remains obscure. Histone deacetylase 11 (HDAC11), the most recently identified histone deacetylase, is the sole member of class IV HDACs. However, its role in diabetic cardiac injury is still poorly understood. In the p...

journal_title：Biochemical and biophysical research communications

authors： Fan XD,Wan LL,Duan M,Lu S

更新日期：2018-09-05 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) glycoprotein E (gE) is a multifunctional protein capable of both binding the Fc portion of IgG and mediating cell-to-cell spread of HSV-1. Here we report that the domain on gE involved in IgG binding is distinct from the domain involved in mediating cell-to-cell spread. To do this we hav...

journal_title：Biochemical and biophysical research communications

authors： Weeks BS,Sundaresan P,Nagashunmugam T,Kang E,Friedman HM

更新日期：1997-06-09 00:00:00