Inhibitors of glycoprotein processing act at an early stage of myogenesis.

abstract：:Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP- ribosylation enzyme and plays important roles in a variety of cellular processes, including DNA damage response and tumor development. However, the post-transcriptional regulation of PARP1 remains largely unknown. In this study, we identified that the mRNA of PARP1 is ...

journal_title：Biochemical and biophysical research communications

authors： Song D,Huang H,Wang J,Zhao Y,Hu X,He F,Yu L,Wu J

更新日期：2017-06-17 00:00:00

abstract：:The effects of different lysophospholipids on endothelium-dependent hyperpolarization by acetylcholine were examined in rat mesenteric arteries. Lysophosphatidylcholine with 14 or longer carbon acyl chain significantly inhibited the hyperpolarization, while that with 12 or lesser carbon acyl chain was without effect. ...

journal_title：Biochemical and biophysical research communications

authors： Fukao M,Hattori Y,Kanno M,Sakuma I,Kitabatake A

更新日期：1996-10-14 00:00:00

abstract：:The phenothiazine antipsychotic drug chlorpromazine, a potent calmodulin antagonist, inhibited human natural killer cell-mediated cytotoxicity in a dose-dependent manner. This inhibition of natural killer cell activity was not due to interference with conjugate formation, nor was it due to toxicity to the natural kill...

journal_title：Biochemical and biophysical research communications

authors： Steele TA,Brahmi Z

更新日期：1988-09-15 00:00:00

abstract：:Neddylation is an ubiquitin-like modification of proteins that affects the activity, stability and protein-protein interaction of its substrates. Apart from its role as a promoter for Cullin ring E3 ligase to positively regulate the ubiquitylation process, other functional studies about neddylation are still lacking. ...

journal_title：Biochemical and biophysical research communications

authors： Li S,Fang W,Cui Y,Shi H,Chen J,Li L,Zhang L,Zhang X

更新日期：2020-09-03 00:00:00

abstract：:A novel cDNA clone was identified through yeast two-hybrid experiments. Following cross-examination between the cDNA clones, EST clones, and the cosmid clone, we could digitally assemble a new zinc finger transcription factor gene. This predicted gene has a cDNA size of about 1960 bp and is translated into a 487-amino...

journal_title：Biochemical and biophysical research communications

authors： Lin W,Lai CH,Tang CJ,Huang CJ,Tang TK

更新日期：1999-11-02 00:00:00

abstract：:The effect of ochratoxin A on the specific activities of phosphoenolpyruvate carboxykinase, gamma-glutamyl transpeptidase and phosphate-dependent glutaminase were investigated in primary cultures of rat kidney proximal convoluted tubule cells grown in a serum-free medium supplemented with growth factors. Addition of o...

journal_title：Biochemical and biophysical research communications

authors： Thekkumkara TJ,Patel MS

更新日期：1989-08-15 00:00:00

abstract：:Listeria monocytogenes is a Gram-positive intracellular bacterium that was transmitted through contaminated food and causes sepsis and even death. IL-37 has been described as an important anti-inflammatory factor, but little is known about the function of IL-37 in host defense against Liseria monocytogenes (Lm) infect...

journal_title：Biochemical and biophysical research communications

authors： Zhao M,Hu Y,Shou J,Su SB,Yang J,Yang T

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:Chondrocytes express many kinds of hormone receptors. The function of Follicle stimulating hormone (FSH) in the ovary is mediated by FSH receptor (FSHR). FSH receptor (FSHR) is found in many non-ovarian tissues, however it has been unclear if chondrocytes express FSHR. The purpose of this study is to determin...

journal_title：Biochemical and biophysical research communications

authors： Kong D,Guan Q,Li G,Xin W,Qi X,Guo Y,Zhao J,Xu J,Sun S,Gao L

更新日期：2018-01-01 00:00:00

abstract：:VDR regulates gene expression in a ligand-dependent way by binding to cognate enhancer elements of target gene promoters. The ligand-dependent activation function, AF-2, of VDR is thought to require transcriptional co-activators/co-repressors together with basal transcriptional machinery. Using a yeast two hybrid syst...

journal_title：Biochemical and biophysical research communications

authors： Imai T,Matsuda K,Shimojima T,Hashimoto T,Masuhiro Y,Kitamoto T,Sugita A,Suzuki K,Matsumoto H,Masushige S,Nogi Y,Muramatsu M,Handa H,Kato S

更新日期：1997-04-28 00:00:00

abstract：:Bloom syndrome (BS) is a rare genetic disorder characterized by small body size, sun sensitivity, immunodeficiency and a high predisposition to various types of cancer. BLM was identified as the causative gene for BS, and BLM protein is homologous to DNA helicase. There are two putative nuclear localization signals (N...

journal_title：Biochemical and biophysical research communications

authors： Kaneko H,Orii KO,Matsui E,Shimozawa N,Fukao T,Matsumoto T,Shimamoto A,Furuichi Y,Hayakawa S,Kasahara K,Kondo N

更新日期：1997-11-17 00:00:00

abstract：:The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is regulated by oxygen availability as well as various inflammatory mediators, including tumor necrosis factor alpha (TNFalpha). Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling...

journal_title：Biochemical and biophysical research communications

authors： Kuo HP,Lee DF,Xia W,Wei Y,Hung MC

更新日期：2009-11-27 00:00:00

abstract：:The force-extension behaviour of synthesized double-stranded DNAs (dsDNAs) designed to have 2.1% or 6.6% of the thymine bases alkyne functionalized was studied using near infrared (NIR) optical tweezers. Measurements were carried out on substrates with and without flurophores covalently attached to the alkyne moiety o...

journal_title：Biochemical and biophysical research communications

authors： Raudsepp A,Kent LM,Hall SB,Williams MAK

更新日期：2018-02-12 00:00:00

abstract：:We have previously reported that intraplatelet "cyclic AMP jumps" produced with newly synthesized photoactivatable cyclic AMP analogue, inhibited washed rat platelet aggregation and serotonin release as induced by thrombin. Using the same approach on human platelets, thrombin-induced platelet aggregation was dose-depe...

journal_title：Biochemical and biophysical research communications

authors： Blache D,Ciavatti M,Ponsin G,Nargeot J

更新日期：1987-07-15 00:00:00

abstract：:De novo prediction of protein structures, the prediction of structures from amino acid sequences which are not similar to those of hitherto resolved structures, has been one of the major challenges in molecular biophysics. In this paper, we develop a new method of de novo prediction, which combines the fragment assemb...

journal_title：Biochemical and biophysical research communications

authors： Sasaki TN,Cetin H,Sasai M

更新日期：2008-05-02 00:00:00

abstract：:Chlamydia trachomatis (C. trachomatis) is an obligate intracellular organism that depends on nutrients from the host cell for their replication and proliferation. Therefore, the interaction between this pathogen and host induces sustained endoplasmic reticulum (ER) stress in the infected cells. Unfolded protein respon...

journal_title：Biochemical and biophysical research communications

authors： Wen Y,Luo F,Zhao Y,Su S,Shu M,Li Z

更新日期：2020-06-30 00:00:00

abstract：:Tauroursodeoxycholic acid (TUDCA) is known to prevent apoptosis through the Bax pathway and to promote neovascularization by enhancing the mobilization of stem cells, their differentiation. This study was performed to investigate the effect of TUDCA on erythropoiesis in hematopoietic stem cells (HSCs). Since erythropo...

journal_title：Biochemical and biophysical research communications

authors： Hong SH,Yoon KJ,Lim KH,Um YJ,Cho JG,Jo YJ,Park SG

更新日期：2016-09-30 00:00:00

abstract：:Class II transactivator (CIITA) plays a critical role in controlling major histocompatibility complex (MHC) class II gene expression. In this study, two novel alternatively spliced variants of human interferon (IFN)-γ-inducible CIITA, one missing exon 7 (CIITAΔE7), the other with TAG inserted at exon 4/5 junction (CII...

journal_title：Biochemical and biophysical research communications

authors： Chiu BL,Li CH,Chang CC

更新日期：2013-10-11 00:00:00

abstract：:We previously reported the first vancomycin-resistant Staphylococcus aureus (VRSA) clinical strain, Mu50, whose cell wall is remarkably thickened resulting from the activation of cell-wall synthesis. To explore the genetic basis for the vancomycin resistance, cDNA differential hybridization was performed using RNAs ex...

journal_title：Biochemical and biophysical research communications

authors： Kuroda M,Kuwahara-Arai K,Hiramatsu K

更新日期：2000-03-16 00:00:00

abstract：:Expression of foreign genes in vivo is a standard method to disclose functions of specific genes and to alter physiological conditions in distinct cell types and tissues. Virus-mediated gene transfer has proved to be a valuable tool for directed gene expression in vivo complementary to transgenic approaches. However, ...

journal_title：Biochemical and biophysical research communications

authors： Ebelt H,Braun T

更新日期：2003-10-31 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of nuclear receptors, is expressed at a high level in adipose tissue and plays an important role in adipocyte differentiation. In the present study, we identified the expression of PPARgamma in rat aortic smooth muscle cells (RASMC) using reverse t...

journal_title：Biochemical and biophysical research communications

authors： Iijima K,Yoshizumi M,Ako J,Eto M,Kim S,Hashimoto M,Sugimoto N,Liang YQ,Sudoh N,Toba K,Ouchi Y

更新日期：1998-06-18 00:00:00

abstract：:Hepatitis C virus (HCV) infects its target cells in the form of cell-free viruses and through cell-cell contact. Here we report that HCV is associated with exosomes. Using highly purified exosomes and transmission electron microscopic imaging, we demonstrated that HCV occurred in both exosome-free and exosome-associat...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Zhang X,Yu Q,He JJ

更新日期：2014-12-12 00:00:00

abstract：:We have isolated calpromotin, a protein reported abundant in human red cells and shown to be of significance for KCl transport. We show that calpromotin is identical to a radical scavenger protein, thiol-specific antioxidant protein (TSA). Calpromotin is known to exist partially as a large complex of identical subunit...

journal_title：Biochemical and biophysical research communications

authors： Kristensen P,Rasmussen DE,Kristensen BI

更新日期：1999-08-19 00:00:00

abstract：:We have synthesized the first enkephalin analog containing a "cyclopropyl" phenylalanine (Phe) residue. The E-configuration of this residue is apparently responsible for its low activity in the MVD and GPI muscle assays. The enkephalin is very stable to cleavage by carboxypeptidase Y. ...

journal_title：Biochemical and biophysical research communications

authors： Kimura H,Stammer CH,Shimohigashi Y,Ren-Lin C,Stewart J

更新日期：1983-08-30 00:00:00

abstract：:Plant reproduction is an extremely important phenomenon, as it is strongly associated with plant genetics and early development. Additionally, foundations of the reproductive system have direct implications on plant breeding and agriculture. Investigation of the functions of male and female gametophytes is critical si...

journal_title：Biochemical and biophysical research communications

authors： Liu X,Wu X,Adhikari PB,Zhu S,Kinoshita Y,Berger F,Higashiyama T,Kasahara RD

更新日期：2020-01-22 00:00:00

abstract：:To study the hierarchical levels of stem cell targets for ABL-kinase domain mutations in CML, highly purified CD34+CD38- and CD34+CD38+ cell populations and their LTC-IC-derived progeny were analyzed in four patients at diagnosis (n=1) or in advanced phases (n=3) of their disease. In the single patient with early phas...

journal_title：Biochemical and biophysical research communications

authors： Sorel N,Bonnet ML,Guillier M,Guilhot F,Brizard A,Turhan AG

更新日期：2004-10-22 00:00:00

abstract：:The beta-subunit of human chorionic gonadotropin (beta-hCG) is secreted by many kinds of tumors and it has been used as an ideal target antigen to develop vaccines against tumors. In view of the low immunogenicity of this self-peptide,we designed a method based on isocaudamer technique to repeat tandemly the 10-residu...

journal_title：Biochemical and biophysical research communications

authors： Yankai Z,Rong Y,Yi H,Wentao L,Rongyue C,Ming Y,Taiming L,Jingjing L,Jie W

更新日期：2006-07-14 00:00:00

abstract：:Elevations in intracellular Ca(2+) ([Ca(2+)](i)) initiate insulin secretion from pancreatic beta-cells, but the secretory responses become rapidly desensitised to maintained elevations in [Ca(2+)](i). We have investigated the mechanisms underlying the Ca(2+) desensitization of insulin secretion using electrically perm...

journal_title：Biochemical and biophysical research communications

authors： Harris TE,Persaud SJ,Squires PE,Jones PM

更新日期：2000-04-21 00:00:00

abstract：:Aggregation of the amyloid beta (Abeta) peptide yields both fibrillar precipitates and soluble oligomers, and is associated with Alzheimer's disease (AD). In vitro, Cu(2+) and Zn(2+) strongly bind Abeta and promote its precipitation. However, less is known about their interactions with the soluble oligomers, which are...

journal_title：Biochemical and biophysical research communications

authors： Garai K,Sengupta P,Sahoo B,Maiti S

更新日期：2006-06-23 00:00:00

abstract：:Brain capillary endothelial cells (BCECs) play an important role in blood-brain barrier (BBB) functions and pathophysiologic mechanisms in brain ischemia and inflammation. We try to suppress gene expression in BCECs by intravenous application of small interfering RNA (siRNA). After injection of large dose siRNA with h...

journal_title：Biochemical and biophysical research communications

authors： Hino T,Yokota T,Ito S,Nishina K,Kang YS,Mori S,Hori S,Kanda T,Terasaki T,Mizusawa H

更新日期：2006-02-03 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that regulate target gene expression through translation repression or messenger RNA degradation. MiR-15a and 16-1 form a cluster at the chromosomal region 13q14, which is frequently deleted or down-regulated in chronic lymphocytic leukemia. Arsenic trioxide (As(2)O(3), ATO)...

journal_title：Biochemical and biophysical research communications

authors： Gao SM,Chen C,Wu J,Tan Y,Yu K,Xing CY,Ye A,Yin L,Jiang L

更新日期：2010-12-10 00:00:00