当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Inhibition of neuroglandular antigen (NGA) glycosylation by phorbol ester in human melanoma cells.

Inhibition of neuroglandular antigen (NGA) glycosylation by phorbol ester in human melanoma cells.

Abstract：

:NGA is a human melanoma-associated antigen recognized by a panel of murine monoclonal antibodies developed in this laboratory. NGA consists of a 23.5 kDa core protein which is glycosylated in vivo to give a family of glycoproteins (30-60 kDa). Treatment of human melanoma G361 cells with the phorbol ester PMA resulted in apparent partial inhibition of NGA glycosylation. After PMA treatment, NGA appeared as 3 different bands of 24, 29 and 34 kDa on SDS-PAGE. The 29 kDa band is similar to the one obtained by treatment with the ionophore monensin, which inhibits NGA O-glycosylation. PMA can modulate plasma membrane ion exchange, most likely by activating protein kinase C. In G361 cells PMA may produce the same net effect as monensin, by impairing transport in the Golgi complex and consequently inhibiting protein O-glycosylation through an ionophore-like effect. Treatment of G361 cells with both PMA and protein kinase C inhibitors re-established the usual NGA glycosylation pattern. Thus the observed effect of PMA on NGA glycosylation is reversible and appears to be mediated by protein kinase C activation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Feyles V,Dixon WT,Sikora LK,Jerry LM

doi

10.1016/0006-291x(89)92798-8

subject

Has Abstract

pub_date

1989-02-15 00:00:00

pages

837-43

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92798-8

journal_volume

158

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Effects of leptin on HPG axis and reproductive function in male rat in simulated altitude of 5500 m hypoxia environment.

    abstract：:High altitude hypobaric hypoxia environment impairs male's reproductive function. Leptin is an adipose tissue-derived hormone which regulates body weight homeostasis. Its receptor (LepR) has been found in all levels of male reproductive axis, indicating that it can affect male reproductive system in a direct or (and) ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.05.194

    authors： Liu X,Liu S,Xu C

    更新日期：2020-08-13 00:00:00

  • First structure of the polymyxin resistance proteins.

    abstract：:PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.07.144

    authors： Fu W,Yang F,Kang X,Zhang X,Li Y,Xia B,Jin C

    更新日期：2007-10-05 00:00:00

  • DRG: a novel developmentally regulated GTP-binding protein.

    abstract：:Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein. The predicted protein of 4...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91567-a

    authors： Sazuka T,Tomooka Y,Ikawa Y,Noda M,Kumar S

    更新日期：1992-11-30 00:00:00

  • The Eλ(3-1) enhancer is essential for V(D)J recombination of the murine immunoglobulin lambda light chain locus.

    abstract：:Enhancers are essential for long range chromatin opening and the activation of V(D)J recombination at the antigen receptor loci. The murine immunoglobulin lambda light chain locus is a duplicated locus and, using a bacterial artificial chromosome spanning the 3' half of the locus to generate transgenic mice, we have i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：

    authors： Haque SF,Bevington SL,Boyes J

    更新日期：2013-11-15 00:00:00

  • A high fat diet-induced impaired glucose metabolism in mice with targeted deletion of calpain in osteoblasts.

    abstract：:The ubiquitously expressed Calpains 1 and 2 belong to a family of calcium-dependent intracellular cysteine proteases. Both calpains are heterodimers consisting of a large subunit and a small regulatory subunit encoded by the gene Capns1. To investigate a role for the calpain small subunit in cells of the osteoblast li...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.04.134

    authors： Kashiwagi A,Fein MJ,Shimada M

    更新日期：2011-06-03 00:00:00

  • Vascular smooth muscle cell spreading onto fibrinogen is regulated by calpains and phospholipase C.

    abstract：:Fibrinogen deposition and smooth muscle cell migration are important causes of atherosclerosis and angiogenesis. Involvement of calpains in vascular smooth muscle cell adhesion onto fibrinogen was investigated. Using calpain inhibitors, we showed that activation of calpains was required for smooth muscle cell spreadin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5859

    authors： Paulhe F,Bogyo A,Chap H,Perret B,Racaud-Sultan C

    更新日期：2001-11-09 00:00:00

  • Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells.

    abstract：:Endoplasmic reticulum (ER) stress is involved in a wide range of pathological conditions including neurodegenerative disorders, diabetes mellitus, atherosclerosis, inflammation, and infection. The ability of ER stress to induce an inflammatory response is considered to play a role in the pathogenesis of these diseases...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.09.132

    authors： Shimasaki S,Koga T,Shuto T,Suico MA,Sato T,Watanabe K,Morino-Koga S,Taura M,Okada S,Mori K,Kai H

    更新日期：2010-11-12 00:00:00

  • Electrospun protein-CNT composite fibers and the application in fibroblast stimulation.

    abstract：:Functional biopolymer scaffolds are in high demand for tissue regeneration. In this study, we incorporated functionalized CNT in collagen or silk protein solution to generate biocomposite fibers by electrospinning. The addition of CNT reinforced the strength of the scaffolds and rendered the fibers electrical conducti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.08.157

    authors： Chi N,Wang R

    更新日期：2018-09-26 00:00:00

  • Appropriate dose of ethanol exerts anti-senescence and anti-atherosclerosis protective effects by activating ALDH2.

    abstract：:Moderate alcohol consumption has been shown to reduce atherosclerosis-associated diseases. As shown in our earlier works, ethanol has a dose-dependent protective effects against endothelial cellular senescence by activating aldehyde dehydrogenase 2 (ALDH2) in vitro. However, whether ethanol administration possesses an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.03.037

    authors： Xue L,Zhu W,Yang F,Dai S,Han Z,Xu F,Guo P,Chen Y

    更新日期：2019-04-30 00:00:00

  • Trypanosoma cruzi: TcRAB7 protein is localized at the Golgi apparatus in epimastigotes.

    abstract：:In mammalian cells, the Rab7 protein is a key element of late endocytic membrane traffic. Several results suggest that it is involved in the transport from early to late endosome or from late endosome to lysosome. We have previously characterized a Rab7 gene homologue (TcRAB7) in Trypanosoma cruzi. Now, using an affin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.06.159

    authors： Araripe JR,Cunha e Silva NL,Leal ST,de Souza W,Rondinelli E

    更新日期：2004-08-20 00:00:00

  • GATA4 loss-of-function mutation underlies familial dilated cardiomyopathy.

    abstract：:The cardiac transcription factor GATA4 is essential for cardiac development, and mutations in this gene have been implicated in a wide variety of congenital heart diseases in both animal models and humans. However, whether mutated GATA4 predisposes to dilated cardiomyopathy (DCM) remains unknown. In this study, the wh...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.09.023

    authors： Li RG,Li L,Qiu XB,Yuan F,Xu L,Li X,Xu YJ,Jiang WF,Jiang JQ,Liu X,Fang WY,Zhang M,Peng LY,Qu XK,Yang YQ

    更新日期：2013-10-04 00:00:00

  • Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice.

    abstract：BACKGROUND:- Tadalafil, a long-acting phosphodiesterase 5 (PDE5) inhibitor, alleviates preeclampsia (PE), and decreases the fetal and infant deaths associated with fetal growth restriction (FGR) in phase II clinical trial. Recently, we demonstrated that tadalafil alleviates FGR and hypertension in the dams with PE indu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.186

    authors： Sekimoto A,Tanaka K,Hashizume Y,Sato E,Sato H,Ikeda T,Takahashi N

    更新日期：2020-01-15 00:00:00

  • Phorbol ester treatment inhibits thrombin but not stable GTP analogue-induced platelet granule secretion despite inhibition of phosphatidate formation with both agonists.

    abstract：:Previous work has demonstrated that pre-treatment of platelets with phorbol esters that activate protein kinase C eg phorbol 12-myristate 13-acetate (PMA) results in an inhibition of inositol phospholipid breakdown and granule secretion induced by physiological agonists such as thrombin and collagen. In the present st...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80768-x

    authors： Krishnamurthi S,Kakkar VV

    更新日期：1988-11-15 00:00:00

  • Activity of four allelic forms of glutathione S-transferase hGSTP1-1 for diol epoxides of polycyclic aromatic hydrocarbons.

    abstract：:Allelic forms of hGSTP1-1 which differ from each other by their catalytic properties and, structurally, by the amino acid(s) in position(s) 104 or (and) 113 are known to exist in human populations. The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 1...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7311

    authors： Hu X,Xia H,Srivastava SK,Herzog C,Awasthi YC,Ji X,Zimniak P,Singh SV

    更新日期：1997-09-18 00:00:00

  • Dystrophins and DAPs are expressed in adipose tissue and are regulated by adipogenesis and extracellular matrix.

    abstract：:The dystrophin-associated protein complex (DAPC), consisting of dystrophin, dystroglycans, sarcoglycans, dystrobrevins and syntrophins, provides a linkage between the cytoskeleton and the extracellular matrix. The disruption of DAPC leads to Duchenne/Becker muscular dystrophy and other neuromuscular diseases. Although...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.12.049

    authors： Romo-Yáñez J,Montañez C,Salazar-Olivo LA

    更新日期：2011-01-14 00:00:00

  • Oxidation-induced persistent activation of protein kinase C in hippocampal homogenates.

    abstract：:Incubation of purified protein kinase C with H2O2 results in the generation of a persistently activated form of the enzyme which is no longer dependent on Ca2+ or lipid cofactors. This oxidative activation of purified protein kinase C requires added Fe2+ in the incubation medium. Treatment of the soluble fraction of h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90463-u

    authors： Palumbo EJ,Sweatt JD,Chen SJ,Klann E

    更新日期：1992-09-30 00:00:00

  • HMGB1-containing nucleosome mediates chemotherapy-induced metastasis of human lung cancer.

    abstract：:While chemotherapy is an important and widely used therapeutic for cancer, it may facilitate cancer metastasis. Herein, we report that human lung cancer cells exert higher invasion and metastasis after chemotherapy. In a human lung cancer xenograft model, chemotherapy promotes the cancer invasion and metastasis in HMG...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.04.150

    authors： Wang K,Shan S,Wang S,Gu X,Zhou X,Ren T

    更新日期：2018-06-07 00:00:00

  • ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma.

    abstract：:Transcriptional factors (TFs) are key regulators in orchestrating gene transcription during cancer development. However, their roles in glioma remain elusive. Here, we analyzed the differential expression of TFs and identified ZNF436 is upregulated in glioblastoma and Lower Grade Glioma patients. High expression of ZN...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.06.004

    authors： Shang Y,Li Y,Zhang Y,Wang J

    更新日期：2019-08-06 00:00:00

  • The role of nitric oxide in delta-aminolevulinic acid (ALA)-induced photosensitivity of cancerous cells.

    abstract：:Application of delta-aminolevulinic acid (ALA) results in the endogenous accumulation of protoporphyrin IX and is a useful approach in the photodynamic therapy (PDT) of cancers. To investigate the role of nitric oxide (NO) in the specific accumulation of protoporphyrin and ALA-induced PDT of cancerous cells, we transf...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.007

    authors： Yamamoto F,Ohgari Y,Yamaki N,Kitajima S,Shimokawa O,Matsui H,Taketani S

    更新日期：2007-02-16 00:00:00

  • Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway.

    abstract：:Sulforaphane, an aliphatic isothiocyanate derived from cruciferous vegetables, is known for its antidiabetic properties. The effects of sulforaphane on lipid metabolism in adipocytes are not clearly understood. Here, we investigated whether sulforaphane stimulates lipolysis. Mature adipocytes were incubated with sulfo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.08.107

    authors： Lee JH,Moon MH,Jeong JK,Park YG,Lee YJ,Seol JW,Park SY

    更新日期：2012-10-05 00:00:00

  • Liposome targeting to mouse brain: mannose as a recognition marker.

    abstract：:Liposomes prepared from lecithin:cholesterol:p-aminophenyl-alpha-mannoside (7:2:1, v/v/v) were efficiently incorporated into the mouse brain across the blood brain barrier. Furthermore, liposomes injected intraperitoneally were exclusively distributed into lysosome rich fraction and also taken up by glial cells. These...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81333-0

    authors： Umezawa F,Eto Y

    更新日期：1988-06-30 00:00:00

  • Up-regulation of uncoupling protein-3 by fatty acid in C2C12 myotubes.

    abstract：:Uncoupling proteins (UCPs) are mitochondrial membrane proton transporters that uncouple oxidative phosphorylation by dissipating the proton gradient across the membrane. We have investigated regulation of the UCP3 gene in skeletal muscle and C2C12 muscle cells. UCP3 mRNA in mouse skeletal muscle is markedly increased ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0662

    authors： Hwang CS,Lane MD

    更新日期：1999-05-10 00:00:00

  • Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X.

    abstract：:The mouse gene encoding the mu opioid receptor, Oprm, undergoes extensive alternatively splicing, with 14 variants having been identified. However, only one variant of human mu opioid receptor gene (Oprm), MOR-1A, has been described. We now report two novel splice variants of the human Oprm gene, hMOR-1O and hMOR-1X. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00089-5

    authors： Pan YX,Xu J,Mahurter L,Xu M,Gilbert AK,Pasternak GW

    更新日期：2003-02-21 00:00:00

  • Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.

    abstract：:To determine whether the two domains of hepatitis C virus (HCV) NS3 and the NS4A interact with each other to regulate the RNA unwinding activity, this study compares the RNA unwinding, ATPase and RNA binding activities of three forms of NS3 proteins--the NS3H protein, containing only the helicase domain, the full-leng...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.032

    authors： Kuang WF,Lin YC,Jean F,Huang YW,Tai CL,Chen DS,Chen PJ,Hwang LH

    更新日期：2004-04-23 00:00:00

  • Many commonly used siRNAs risk off-target activity.

    abstract：:Using small interfering RNA (siRNA) to induce sequence specific gene silencing is fast becoming a standard tool in functional genomics. As siRNAs in some cases tolerate mismatches with the mRNA target, knockdown of genes other than the intended target could make results difficult to interpret. In an investigation of 3...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.175

    authors： Snøve O Jr,Holen T

    更新日期：2004-06-18 00:00:00

  • Cell cycle dependent telomere regulation by telomerase in human bone marrow mesenchymal stem cells.

    abstract：:Human bone marrow mesenchymal stem cells (hMSCs) are a promising source for clinical stem cell transplantation. However, telomere regulation mechanisms, as one of the possible major mechanisms by which hMSCs sustain their stem cell characteristics, remain unknown. We isolated hMSCs by plastic adhesion and characterize...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.011

    authors： Zhao YM,Li JY,Lan JP,Lai XY,Luo Y,Sun J,Yu J,Zhu YY,Zeng FF,Zhou Q,Huang H

    更新日期：2008-05-16 00:00:00

  • Arabidopsis AAL-toxin-resistant mutant atr1 shows enhanced tolerance to programmed cell death induced by reactive oxygen species.

    abstract：:The fungal AAL-toxin triggers programmed cell death (PCD) through perturbations of sphingolipid metabolism in AAL-toxin-sensitive plants. While Arabidopsis is relatively insensitive to the toxin, the loh2 mutant exhibits increased susceptibility to AAL-toxin due to the knockout of a gene involved in sphingolipid metab...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.08.056

    authors： Gechev TS,Ferwerda MA,Mehterov N,Laloi C,Qureshi MK,Hille J

    更新日期：2008-10-31 00:00:00

  • A regulatory role of Wnt signaling pathway in the hematopoietic differentiation of murine embryonic stem cells.

    abstract：:One of the most important issues in stem cell research is to understand the regulatory mechanisms responsible for their differentiation. An extensive understanding of mechanism underlying the process of differentiation is crucial in order to prompt stem cells to perform a particular function after differentiation. To ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.09.206

    authors： Feng Z,Srivastava AS,Mishra R,Carrier E

    更新日期：2004-11-26 00:00:00

  • Plant calreticulin is specifically and efficiently phosphorylated by protein kinase CK2.

    abstract：:Calreticulin isolated from spinach leaves has been specifically phosphorylated in vitro by protein kinase CK2 while animal calreticulin from rabbit liver is not a substrate of this kinase under the same conditions. Phosphoserine is the only phosphoamino acid detected. High affinity binding (Km = 4.4 microM) and a near...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0625

    authors： Baldan B,Navazio L,Friso A,Mariani P,Meggio F

    更新日期：1996-04-25 00:00:00

  • Trafficking and surface expression of the glutamate receptor subunit, KA2.

    abstract：:Kainate receptors are a class of ionotropic glutamate receptors that are widely expressed in the mammalian brain, yet little is known about their physiological role or the mechanisms by which they are regulated. Kainate receptors are composed of multiple subunits (GluR5-7; KA1-2), which can combine to form homomeric o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.08.115

    authors： Hayes DM,Braud S,Hurtado DE,McCallum J,Standley S,Isaac JT,Roche KW

    更新日期：2003-10-10 00:00:00