当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Diferric transferrin reduction stimulates the Na+/H+ antiport of HeLa cells.

Diferric transferrin reduction stimulates the Na+/H+ antiport of HeLa cells.

Abstract：

:Proton release from HeLa cells is stimulated by external oxidants for the transplasmalemma electron transport enzymes. These oxidants, such as ferricyanide and diferric transferrin, also stimulate cell growth. We now present evidence that proton release associated with the reduction of ferricyanide and diferric transferrin is through the Na+/H+ antiport. The stoichiometry of H+/e- release with diferric transferrin is over 50 to 1, which is greater than expected for oxidation of a protonated transmembrane electron carrier. Diferric transferrin induced proton release depends on external sodium and is inhibited by amiloride. Proton release is also inhibited when diferric transferrin reduction is inhibited by apotransferrin. A tightly coupled association between the redox system and the antiport is shown by sodium dependence and amiloride inhibition of diferric transferrin reduction. The results indicate a new role for ferric transferrin in growth stimulation by activation of the sodium-proton antiport.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sun IL,Garcia-Cañero R,Liu W,Toole-Simms W,Crane FL,Morré DJ,Löw H

doi

10.1016/0006-291x(87)91344-1

subject

Has Abstract

pub_date

1987-05-29 00:00:00

pages

467-73

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)91344-1

journal_volume

145

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion.

    abstract：BACKGROUND:Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. METHODS AND RESULTS:In this st...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.01.023

    authors： Yamamoto H,Kuroda N,Uekita H,Kochi I,Matsumoto A,Niinaga R,Funahashi T,Shimomura I,Kihara S

    更新日期：2016-02-05 00:00:00

  • MicroRNA let-7i induced autophagy to protect T cell from apoptosis by targeting IGF1R.

    abstract：:MicroRNA let-7i is up-regulated in T cells from patients with Ankylosing Spondylitis (AS). In this study, we investigated the role of let-7i in T cells survival. Our results demonstrated down-regulation of insulin-like growth factor-1 receptor (IGF1R) in T cells from patients with AS. Luciferase reporter assay suggest...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.10.002

    authors： Hou C,Zhu M,Sun M,Lin Y

    更新日期：2014-10-31 00:00:00

  • Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division.

    abstract：:Emp, originally detected in erythroblastic islands, is expressed in numerous cell types and tissues suggesting a functionality not limited to hematopoiesis. To study the function of Emp in non-hematopoietic cells, an epitope-tagged recombinant human Emp was expressed in HEK cells. Preliminary studies revealed that Emp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.02.060

    authors： Bala S,Kumar A,Soni S,Sinha S,Hanspal M

    更新日期：2006-04-21 00:00:00

  • Epigenetic regulation of the metallothionein-1A promoter by PU.1 during differentiation of THP-1 cells.

    abstract：:We recently demonstrated that metallothionein (MT)-1 A is a direct target gene negatively regulated by PU.1. In this study, we revealed that the expression of PU.1 was increased and accompanied by downregulation of MT-1A expression during TPA-induced THP-1 monocyte differentiation. Chromatin immunoprecipitation (ChIP)...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.03.007

    authors： Suzuki S,Nakano H,Takahashi S

    更新日期：2013-04-12 00:00:00

  • The evaluation of Cannabidiol's effect on the immunotherapy of Burkitt lymphoma.

    abstract：AIM:AF1q has a precise oncogenic function. The purpose of this study is to investigate whether CBD has an effect on the AF1q/ICAM-1 regulatory axis in Burkitt's lymphoma (BL), and thus has potential to enhance immunotherapy and reduce side effects. METHODS:We established BL cell lines with altered AF1q expression usin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.001

    authors： Togano T,Kim N,Kim N,Park GS,Park AK,Bennet M,Park J

    更新日期：2019-11-26 00:00:00

  • Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 reduces pancreatic β-cells apoptosis in glucotoxicity through activation of autophagy.

    abstract：:Chronic elevated glucose is harmful to pancreatic β-cells, resulting in pancreatic β-cells dysfunction and apoptosis. Understanding the molecular mechanisms associated with β-cells survival is pivotal for the prevention of β-cells injury caused by glucotoxicity. The role of Phosphatase and tensin homologue (PTEN)-indu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.05.116

    authors： Zhang J,Chen K,Wang L,Wan X,Shrestha C,Zhou J,Mo Z

    更新日期：2016-08-05 00:00:00

  • Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.

    abstract：:We have cloned the cDNA encoding human PICK1 (protein interacting with C kinase 1), a PDZ domain-containing protein of 415 amino acids, and also identified the Drosophila homologue by search of the databank. Northern blot analysis shows a single mRNA of about 2.0 kb ubiquitously expressed in human tissues. Although PI...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1932

    authors： Takeya R,Takeshige K,Sumimoto H

    更新日期：2000-01-07 00:00:00

  • The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.

    abstract：:Peripheral noxious stimulation leads to phosphorylation and thereby activation of the transcription factor CREB in the spinal cord. CREB phosphorylation occurs mainly at serine 133, but the phosphorylation site at serine 142 may also be important. We investigated the impact of spinal CREB protein levels and phosphoryl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.07.148

    authors： Niederberger E,Ehnert C,Gao W,Coste O,Schmidtko A,Popp L,Gall CV,Korf HW,Tegeder I,Geisslinger G

    更新日期：2007-10-12 00:00:00

  • Identification of structural domains affecting transactivation potential of Nm23.

    abstract：:The strong transactivation activity of the C-terminal half (amino acids 76-152) of Nm23 was reported previously. Here we examined a structural domain preventing or necessary to its transactivation activity. The C-terminal 1/4 (amino acids 109-152) was sufficient for transactivation, but the C-terminal half with a long...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.6042

    authors： Cho SJ,Lee NS,Jung YS,Lee H,Lee KJ,Kim E,Chae SK

    更新日期：2001-12-07 00:00:00

  • Adaptor proteins GIR1 and GIR2. I. Interaction with the repressor GLABRA2 and regulation of root hair development.

    abstract：:Plants use specialized root outgrowths, termed root hairs, to enhance acquisition of nutrients and water, help secure anchorage, and facilitate interactions with soil microbiome. One of the major regulators of this process is GLABRA2 (GL2), a transcriptional repressor of root hair differentiation. However, regulation ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.05.084

    authors： Wu R,Citovsky V

    更新日期：2017-07-01 00:00:00

  • Identification of miR-2400 gene as a novel regulator in skeletal muscle satellite cells proliferation by targeting MYOG gene.

    abstract：:MicroRNAs play critical roles in skeletal muscle development as well as in regulation of muscle cell proliferation and differentiation. Previous study in our laboratory showed that the expression level of miR-2400, a novel and unique miRNA from bovine, had significantly changed in skeletal muscle-derived satellite cel...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.05.112

    authors： Zhang WW,Tong HL,Sun XF,Hu Q,Yang Y,Li SF,Yan YQ,Li GP

    更新日期：2015-08-07 00:00:00

  • Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b.

    abstract：:Sarafotoxins (SRTXs) are endothelin-like peptides extracted from snake venom. SRTXs stimulate the endothelin ETA and ETB receptors and enhance vasoconstriction, followed by left ventricular dysfunction and bronchoconstriction. SRTXs include four major isopeptides, S6a-d, with different subtype selectivities. Here, we ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.12.091

    authors： Izume T,Miyauchi H,Shihoya W,Nureki O

    更新日期：2020-07-23 00:00:00

  • Metabolism of lipoxins A4 and B4 and of their all-trans isomers by human leukocytes and rat liver microsomes.

    abstract：:Incubation of lipoxin A4 (LXA4) either with human leukocytes or with rat liver microsomes in the presence of NADPH very selectively led to a more polar metabolite retaining the conjugated tetraenic structure of LXA4. Lipoxin B4 (LXB4) underwent a very similar metabolism into a more polar metabolite, whereas the all-tr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91958-f

    authors： Boucher JL,Delaforge M,Mansuy D

    更新日期：1991-05-31 00:00:00

  • A new approach to possible substrate binding mechanisms for nitrile hydratase.

    abstract：:We combined normal mode analysis (NMA) with cavity calculations as a method to get more insight into static crystal structures. We used nitrile hydratase (NHase) as a case study, and the crystal structure of a complex of Pseudonocardia thermophila NHase (1UGP) with n-butyric acid was chosen as a reference structure. T...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.02.150

    authors： Taştan Bishop AO,Sewell T

    更新日期：2006-04-28 00:00:00

  • N-linked glycans do not affect plasma membrane localization of multidrug resistance protein 4 (MRP4) but selectively alter its prostaglandin E2 transport activity.

    abstract：:Multidrug resistance protein 4 (MRP4) is a member of subfamily C of the ATP-binding cassette superfamily of membrane transport proteins. MRP4 mediates the ATP-dependent efflux of many endogenous and exogenous solutes across the plasma membrane, and in polarized cells, it localizes to the apical or basolateral plasma m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.12.095

    authors： Miah MF,Conseil G,Cole SP

    更新日期：2016-01-22 00:00:00

  • An inhibitor of c-Jun N-terminal kinases (CEP-11004) counteracts the anti-HIV-1 action of trichosanthin.

    abstract：:Trichosanthin (TCS) is a type I ribosome-inactivating protein possessing multiple biological and pharmacological activities. One of its major actions is inhibition of human immunodeficiency virus (HIV) replication. The mechanism is still not clear. It is generally believed that this action is mediated via ribosome ina...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.11.004

    authors： Ouyang DY,Chan H,Wang YY,Huang H,Tam SC,Zheng YT

    更新日期：2006-01-06 00:00:00

  • Overexpression of stearoyl-CoA desaturase-1 results in an increase of conjugated linoleic acid (CLA) and n-7 fatty acids in 293 cells.

    abstract：:The effect of human SCD1 heterologous expression on cellular fatty acid synthesis was investigated in the current study. The SCD1 gene expression cassette and PGK-neomycin-selectable marker cassette were co-introduced into HEK 293 cells by electroporation, and subsequently, SCD1 expression was evaluated by fatty acid ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.06.102

    authors： Wu Z,Li D,Gou K

    更新日期：2010-07-30 00:00:00

  • Low false positive and accurate detection of yeast cell viability and concentration using an automatic staining and lensfree imaging platform.

    abstract：:Yeast cell viability and concentration are the crucial factors affecting product quality in food industry and bio-fuel production, as well as the evaluation basis for environmental toxic compounds. To overcome the drawbacks of existing methods, including high error, false positive and low automation, we propose a high...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.155

    authors： Li G,Wei M,Sun J,Zhang Y,Zhang R

    更新日期：2020-05-07 00:00:00

  • Fasting activates the gene expression of UCP3 independent of genes necessary for lipid transport and oxidation in skeletal muscle.

    abstract：:Fasting triggers a complex array of adaptive metabolic and hormonal responses including an augmentation in the capacity for mitochondrial fatty acid (FA) oxidation in skeletal muscle. This study hypothesized that this adaptive response is mediated by increased mRNA of key genes central to the regulation of fat oxidati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0006-291X(02)00473-4

    authors： Tunstall RJ,Mehan KA,Hargreaves M,Spriet LL,Cameron-Smith D

    更新日期：2002-06-07 00:00:00

  • MARs mission update.

    abstract：:Genes are organized as chromatin domains and positioned in the nucleus through regions of nuclear matrix association, termed MARs. Although well-studied, the mechanisms regulating expression of the beta-globin locus remain an enigma. Here, we show that certain MAR sequences of the beta-globin locus are conserved and r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7939

    authors： Walter WR,Singh GB,Krawetz SA

    更新日期：1998-01-14 00:00:00

  • Identification of novel serum proteins in a Japanese viper: homologs of mammalian PSP94.

    abstract：:Three small serum proteins (SSP-1, -2, and -3), with molecular masses of 6.5-10kDa, were isolated from Habu (Trimeresurus flavoviridis) serum, and the amino acid sequences were determined by protein and cDNA analysis. Despite only limited sequence identity to any mammalian prostatic secretory protein of 94 amino acids...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.05.091

    authors： Aoki N,Sakiyama A,Deshimaru M,Terada S

    更新日期：2007-07-27 00:00:00

  • Sodium ion modulates collagen types in human fibroblastic cells in culture.

    abstract：:Collagen synthesis in human fibroblasts was increased by the presence of 0.1M excess NaCl in the culture medium. Type analysis of the collagen produced by the cells showed the increase in the ratio of type III collagen to the total collagen. Similar NaCl effects were observed in several cell lines derived from differe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91577-2

    authors： Hata R,Sunada H,Nagai Y

    更新日期：1983-11-30 00:00:00

  • Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells.

    abstract：:We herein report two new genes, human neugrin and mouse homologue m-neugrin, found by screening the cDNA library for the human spinal cord. The neugrin mRNA encodes 219 amino acids and its deduced amino acid sequence contains an NLS-like domain. No previously known motif is found in it. m-neugrin mRNA encodes 233 amin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3971

    authors： Ishigaki S,Niwa J,Yoshihara T,Mitsuma N,Doyu M,Sobue G

    更新日期：2000-12-20 00:00:00

  • ERC-55, a binding protein for the papilloma virus E6 oncoprotein, specifically interacts with vitamin D receptor among nuclear receptors.

    abstract：:VDR regulates gene expression in a ligand-dependent way by binding to cognate enhancer elements of target gene promoters. The ligand-dependent activation function, AF-2, of VDR is thought to require transcriptional co-activators/co-repressors together with basal transcriptional machinery. Using a yeast two hybrid syst...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6531

    authors： Imai T,Matsuda K,Shimojima T,Hashimoto T,Masuhiro Y,Kitamoto T,Sugita A,Suzuki K,Matsumoto H,Masushige S,Nogi Y,Muramatsu M,Handa H,Kato S

    更新日期：1997-04-28 00:00:00

  • Independent inhibition of DNA synthesis by protein kinase C, cyclic AMP and interferon alpha/beta in rabbit aortic smooth muscle cells.

    abstract：:In quiescent cultures of rabbit aortic smooth muscle cells, whole blood serum-induced DNA synthesis was inhibited markedly by protein kinase C-activating 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and phorbol-12, 13-dibutyrate (PDBu), cyclic AMP-derivatives, such as dibutyryl cyclic AMP (Bt2cAMP) and 8-bromo-cyclic A...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80052-4

    authors： Fukumoto Y,Kawahara Y,Kariya K,Araki S,Fukuzaki H,Takai Y

    更新日期：1988-11-30 00:00:00

  • Genetic characterization of an Escherichia coli mutant deficient in organophosphonate biodegradation.

    abstract：:An E. coli mutant deficient in organophosphonate biodegradation has been complemented with a cosmid library prepared from a BamHI partial digest of wild-type E. coli W3110. Mutant E. coli SL724, when transformed with cosmid pSL163 and plasmid pSL263, regained the ability to exploit ethylphosphonate as a sole source of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91088-6

    authors： Loo SH,Peters NK,Frost JW

    更新日期：1987-10-14 00:00:00

  • miR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis in osteosarcoma cells.

    abstract：:miR-130b was significantly up-regulated in osteosarcoma (OS) cells. Naked cuticle homolog 2 (NKD2) inhibited tumor growth and metastasis in OS by suppressing Wnt signaling. We used three miRNA target analysis tools to identify potential targets of miR-130b, and found that NKD2 is a potential target of miR-130b. Based ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.02.050

    authors： Li Z,Li Y,Wang N,Yang L,Zhao W,Zeng X

    更新日期：2016-03-18 00:00:00

  • Toosendanin induces caspase-dependent apoptosis through the p38 MAPK pathway in human gastric cancer cells.

    abstract：:Although many advances have been made in the treatment of gastric cancer (GC), numerous difficulties, such as the emergence of chemo-drug resistance, continue to lead to disappointing GC prognoses. Thus, novel alternative strategies are urgently needed. The use of natural products could be a viable option to treat GC....

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.09.093

    authors： Zhou Q,Wu X,Wen C,Wang H,Wang H,Liu H,Peng J

    更新日期：2018-10-20 00:00:00

  • Anticancer, antibacterial and pollutant degradation potential of silver nanoparticles from Hyphaene thebaica.

    abstract：:We present here the biosynthesis of AgNps from the aqueous extract of H. thebaica fruit, and monitored through UV-Vis spectrophotometer. The functional group were characterized through ATR-FTIR spectroscopy, the particle size, morphologies and elemental composition of the nanoparticles were investigated by using TEM, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.06.136

    authors： Bello BA,Khan SA,Khan JA,Syed FQ,Mirza MB,Shah L,Khan SB

    更新日期：2017-08-26 00:00:00

  • Modulation of fluoropyrimidine metabolism by chlorpromazine.

    abstract：:Chlorpromazine is a potent inhibitor of calmodulin and can alter the accumulation, metabolism, and incorporation into RNA of several fluoropyrimidine drugs. Using S-180 murine sarcoma cells, the accumulation of the base Fluorouracil and its metabolism to ribonucleotides is enhanced by chlorpromazine treatment, as meas...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80596-4

    authors： Tseng A Jr,Brooks M,Cadman E

    更新日期：1986-07-31 00:00:00