The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.

abstract：:Here we describe differences in the formation of the epinephrine-induced Ca2+ transients between parent and Ki-ras-transformed NIH3T3 fibroblasts. These transients proved to be the results of an efflux from both the thapsigargin-sensitive and -insensitive intracellular pools. While the epinephrine-induced detachment o...

journal_title：Biochemical and biophysical research communications

authors： Tóth S,Fu T,Nozawa Y,Csaba G

更新日期：1993-01-29 00:00:00

abstract：:Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancers and the leading cause of cancer-related death for both men and women. Recent studies have revealed that a small sub-population of cancer cells, termed cancer stem-like cells (CSCs)/cancer-initiating cells (CICs), are endowed with tumor-initiati...

journal_title：Biochemical and biophysical research communications

authors： Wang L,Hirohashi Y,Ogawa T,Shen M,Takeda R,Murai A,Yamamoto E,Kubo T,Nakatsugawa M,Kanaseki T,Tsukahara T,Nishidate T,Okita K,Kutomi G,Sato N,Takemasa I,Torigoe T

更新日期：2017-04-29 00:00:00

abstract：:Activation of protein kinase C delta (PKCδ) has been linked to the neuroinflammation but the relationship with the various neurodegenerative diseases including the Alzheimer's disease (AD) was mostly elusive. In the AD brains, the special phospholipids, ethanolamine plasmalogens (Pls), were found to be reduced and our...

journal_title：Biochemical and biophysical research communications

authors： Sejimo S,Hossain MS,Akashi K

更新日期：2018-09-05 00:00:00

abstract：:Efficient phagocytic clearance of apoptotic spermatogenic cells and residual bodies (RBs) by Sertoli cells (SCs) is crucial for functional mature spermatogenesis. However, little is known about the molecular mechanisms underlying this SCs function. Herein, we reported for the first time that SCs-expressing metastasis ...

journal_title：Biochemical and biophysical research communications

authors： Zhu CJ,Zhang S,Liang Y,Li W

更新日期：2014-03-14 00:00:00

abstract：:Reelin is a secreted glycoprotein essential for normal brain development and function. In the extracellular milieu, Reelin is subject to specific cleavage at two (N-t and C-t) sites. The N-t cleavage of Reelin is implicated in psychiatric and Alzheimer's diseases, but the molecular mechanism and physiological signific...

journal_title：Biochemical and biophysical research communications

authors： Kohno S,Kohno T,Nakano Y,Suzuki K,Ishii M,Tagami H,Baba A,Hattori M

更新日期：2009-02-27 00:00:00

abstract：:A novel protein kinase activity was characterized from the cytosolic fraction of isolated rabbit gastric glands. The kinase phosphorylated a major 33,000 Da endogenous protein (pp33) and was stimulated by Zn2+ and Mn2+ with Kact of 1.0 and 7.5 mM, respectively. Mg2+ and Ca2+ failed to stimulate any pp33 kinase activit...

journal_title：Biochemical and biophysical research communications

authors： Goldenring JR,Oddsdottir M,Modlin IM

更新日期：1987-01-30 00:00:00

abstract：:Isolation of pure acinar cells of the rat pancreas was achieved employing counterflow sedimentation filtration technique (CSFT). The preparation of purified acinar cells contained an occasional red blood cell (RBC, 200:1) with total absence of endocrine and duct cells. A significant stimulation of amylase secretion fr...

journal_title：Biochemical and biophysical research communications

authors： Bandisode MS,Singh M

更新日期：1985-05-31 00:00:00

abstract：:Hepatitis B, a major public health concern worldwide, is caused by hepatitis type B virus, a hepdnavirus that infects only human and certain nonhuman primates, and replicates strictly in hepatocytes. By using the techniques of slot and Southern blot DNA hybridization, and electron microscopy, the presence of HBV was i...

journal_title：Biochemical and biophysical research communications

authors： Pao CC,Wu SY,Hung IJ,Ng KT,Liaw YF,Lo SJ

更新日期：1987-07-31 00:00:00

abstract：:In this study, we use HRMAS NMR as a non-invasive technique to monitor the in vivo metabolism of a xenobiotic. The antituberculosis Ethionamide is a pro-drug that has to be activated in mycobacteria before inhibiting its cellular target. The use of (1)H HRMAS NMR has allowed to detect a metabolite (ETH*) of the drug d...

journal_title：Biochemical and biophysical research communications

authors： Hanoulle X,Wieruszeski JM,Rousselot-Pailley P,Landrieu I,Baulard AR,Lippens G

更新日期：2005-06-03 00:00:00

abstract：:In a primary cell culture system of fetal rat brain, the calmodulin-dependent protein-kinase IV (CaMKIV) could be induced by the thyroid hormone T3 in a time- and concentration-dependent manner, provided the tissue was excised not later than day 15 of gestation (E15) (Krebs et al., J. Biol. Chem. 271, 11055, 1996). We...

journal_title：Biochemical and biophysical research communications

authors： Krebs J,Wilson A,Kisielow P

更新日期：1997-12-18 00:00:00

abstract：:Effect of recombinant human interleukin-11 (rhIL-11) on the expression of transcripts encoding microsomal heme oxygenase (HO), the rate-limiting enzyme in heme catabolism, and haptoglobin (Hpt), a major acute-phase protein, were examined in human HepG2 hepatoma cells. Treatment of HepG2 cells with rhIL-11 elicited an ...

journal_title：Biochemical and biophysical research communications

authors： Fukuda Y,Sassa S

更新日期：1993-05-28 00:00:00

abstract：:Farnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism. In the present study, we identified RECK, a membrane-anchored inhibitor ...

journal_title：Biochemical and biophysical research communications

authors： Peng X,Wu W,Zhu B,Sun Z,Ji L,Ruan Y,Zhou M,Zhou L,Gu J

更新日期：2014-01-03 00:00:00

abstract：:The alkalization of intracellular pH (pHin) advances together with enhancement of aerobic glycolysis within tumor cells (the Warburg effect), and that is responsible for the progression of tumor malignancy together with hypoxia and angiogenesis. But how they correlate each other during tumor growth is poorly understoo...

journal_title：Biochemical and biophysical research communications

authors： Tanaka S,Harada H,Hiraoka M

更新日期：2015-09-04 00:00:00

abstract：RATIONALE:Islet-1 positive (Islet-1(+)) cardiac progenitor cells give rise to the right ventricle, atria and outflow tract during murine cardiac development. In the adult heart Islet-1 expression is limited to parasympathetic neurons, few cardiomyocytes, smooth muscle cells, within the proximal aorta and pulmonary arte...

journal_title：Biochemical and biophysical research communications

authors： Weinberger F,Mehrkens D,Starbatty J,Nicol P,Eschenhagen T

更新日期：2015-01-02 00:00:00

abstract：:In order to evaluate the receptor subtypes of arginine vasopressin (AVP) in early proximal tubule (S1), outer medullary thick ascending limb of Henle's loop (MTAL) and collecting tubule (OMCT), the effect of AVP on intracellular free calcium ([Ca++]i) was determined using the fluorescence indicator Fura-2. Physiologic...

journal_title：Biochemical and biophysical research communications

authors： Jung KY,Endou H

更新日期：1991-10-15 00:00:00

abstract：:The carboxyl-terminal domain of the zeta 1 subunit of the mouse NMDA receptor channel produced as a fusion protein with GST was phosphorylated in vitro by PKC. A mutant of the zeta 1 subunit without serine or threonine residues in the carboxyl-terminal domain (zeta 1-2-NST) was constructed and was expressed alone or t...

journal_title：Biochemical and biophysical research communications

authors： Yamakura T,Mori H,Shimoji K,Mishina M

更新日期：1993-11-15 00:00:00

abstract：:TRPA1 of insects and several tetrapod vertebrates except for those of rodents have been reported to be activated by noxious chemicals and also by high temperature with a relatively clear threshold. We previously analyzed the characteristics of two TRPA1 paralogs of zebrafish (zTRPA1a, b) and demonstrated that zTRPA1a ...

journal_title：Biochemical and biophysical research communications

authors： Oda M,Saito K,Hatta S,Kubo Y,Saitoh O

更新日期：2017-12-09 00:00:00

abstract：:Activities of the hepadnavirus polymerases are known to include those of DNA polymerase, reverse transcriptase and RNase H. To date, it has been difficult or impossible to clone and express the product as an active enzyme. In this study, full length capped RNA encoding Duck Hepatitis B Virus (DHBV) polymerase was prod...

journal_title：Biochemical and biophysical research communications

authors： Howe AY,Elliott JF,Tyrrell DL

更新日期：1992-12-15 00:00:00

abstract：:Action of protein kinases and phosphatases contributes to myocardial hypertrophy. PRL-3, a protein tyrosine phosphatase, was identified in a cDNA library from an explanted human heart obtained from a patient with idiopathic cardiomyopathy. PRL-3 is expressed in heart and skeletal muscle, exhibiting approximately 76% i...

journal_title：Biochemical and biophysical research communications

authors： Matter WF,Estridge T,Zhang C,Belagaje R,Stancato L,Dixon J,Johnson B,Bloem L,Pickard T,Donaghue M,Acton S,Jeyaseelan R,Kadambi V,Vlahos CJ

更新日期：2001-05-25 00:00:00

abstract：:Several studies have demonstrated that connexin 43 (Cx43) mediates signals important for osteoblast function and osteogenesis. The role of gap junctional communication in bone resorption is less clear. We have investigated the expression of Cx43 mRNA in osteoclasts and bone resorption cultures and furthermore, the fun...

journal_title：Biochemical and biophysical research communications

authors： Ransjö M,Sahli J,Lie A

更新日期：2003-04-18 00:00:00

abstract：:The protein kinase CK2 holoenzyme is composed of two regulatory beta- and two catalytic alpha- or alpha(')-subunits. There is ample evidence for the binding of individual subunits of CK2 to various cellular proteins and, moreover, for functions of the individual subunits, which are different from their roles in the ho...

journal_title：Biochemical and biophysical research communications

authors： Faust M,Kartarius S,Schwindling SL,Montenarh M

更新日期：2002-08-09 00:00:00

abstract：:After proliferative activation of rat liver cells in vivo by a partial hepatectomy a decrease of the calmodulin content in the three plasma membrane domains (blood sinusoidal, canalicular and lateral) was observed. At 24 hours after partial hepatectomy calmodulin was found to be 3 fold lower in the sinusoidal and late...

journal_title：Biochemical and biophysical research communications

authors： Pujades C,Bastos R,Enrich C,Bachs O

更新日期：1990-12-31 00:00:00

abstract：:The biological significance of isoprenoid compounds such as ubiquinones, prenols and sterols have been well established. The presence and biological function of the two quinones Q6 and Q8 in the cattle filarial parasite Setaria digitata have already been reported. Inhibition of the function of quinone was already show...

journal_title：Biochemical and biophysical research communications

authors： Kumari GA,Santhamma KR,Raj RK

更新日期：1994-11-30 00:00:00

abstract：:Osteoclastogenesis is dependent on distinct stimuli that prime and activate osteoclast differentiation. One cytokine needed to prime monocytes for osteoclastogenesis is TGF-beta, which enables and augments RANKL and TNF-alpha-induced osteoclast differentiation. However, the precise time-period during which this occurs...

journal_title：Biochemical and biophysical research communications

authors： Fox SW,Evans KE,Lovibond AC

更新日期：2008-02-01 00:00:00

abstract：:Monoamine oxidase B (MAO-B) functions in the deamination of monoamines, including dopamine and norepinephrine. The search for MAO-B inhibitors increased following the discovery that the enzyme may be responsible for generating neurotoxins from various endogenous or exogenous compounds. Computational screening methods ...

journal_title：Biochemical and biophysical research communications

authors： Harkcom WT,Bevan DR

更新日期：2007-08-24 00:00:00

abstract：:Effects of growth hormone on morphology and cytoskeletal protein expression were examined in 3T3-F442A preadipocytes in serum-free medium. Between 2 and 5 days of culture 2 nM methionyl human growth hormone converted 3T3-F442A cells from a flat fibroblastic morphology to a rounded form with numerous membrane convoluti...

journal_title：Biochemical and biophysical research communications

authors： Guller S,Corin RE,Wu KY,Sonenberg M

更新日期：1989-09-15 00:00:00

abstract：:Cholesterol is a critical component of lipid rafts implicated in regulating multiple signal transduction. The anthrax toxin receptor 2 (ANTXR2) is a type I membrane protein acting as the second receptor for the anthrax toxin. In this study, we first investigated the association between cholesterol and ANTXR2. We provi...

journal_title：Biochemical and biophysical research communications

authors： Zou J,Xu L,Ju Y,Zhang P,Wang Y,Zhang B

更新日期：2014-09-12 00:00:00

abstract：:Alpha-Galactosidase, the product of the melA gene, was purified from a strain of Escherichia coli harboring a plasmid carrying melA, which over-produced the alpha-galactosidase. An apparent molecular weight was determined to be 50 kDa. The amino acid composition of this enzyme was determined. The result indicates that...

journal_title：Biochemical and biophysical research communications

authors： Nagao Y,Nakada T,Imoto M,Shimamoto T,Sakai S,Tsuda M,Tsuchiya T

更新日期：1988-02-29 00:00:00

abstract：:Transgenic mice expressing nuclear sterol regulatory element-binding protein-1a under the control of the insulin promoter were generated to determine the role of SREBP-1a in pancreatic beta-cells. Only low expressors could be established, which exhibited mild hyperglycemia, impaired glucose tolerance, and reduced plas...

journal_title：Biochemical and biophysical research communications

authors： Iwasaki Y,Iwasaki H,Yatoh S,Ishikawa M,Kato T,Matsuzaka T,Nakagawa Y,Yahagi N,Kobayashi K,Takahashi A,Suzuki H,Yamada N,Shimano H

更新日期：2009-01-16 00:00:00

abstract：:In this report we describe the initial characterization of murine, human, and Drosophila hesr-1 (for hairy and enhancer of split related-1) a novel evolutionary conserved family of hairy/enhancer of split homologs. Hesr-1 cDNAs display features typical of hairy and enhancer of split-type bHLH proteins including a N-te...

journal_title：Biochemical and biophysical research communications

authors： Kokubo H,Lun Y,Johnson RL

更新日期：1999-07-05 00:00:00